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3.4.21.B7: mannan-binding lectin-associated serine protease 1

This is an abbreviated version!
For detailed information about mannan-binding lectin-associated serine protease 1, go to the full flat file.

Word Map on EC 3.4.21.B7

Reaction

endopeptidase activity. It triggers the activation of complement cascade by activating the C4 and C2 components. It activates the C4 component by cleaving the alpha-chain of C4 =

Synonyms

mannan-binding lectin-associated serine protease, mannan-binding lectin-associated serine protease-1, mannose-binding lectin-associated serine protease, MASP-1, MASP1, MBL-associated serine protease, MBL-associated serine protease 1, MBL-associated serine protease-1, MBL-MASP, P100, Ra-reactive factor, RaRF, S01.198

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B7 mannan-binding lectin-associated serine protease 1

Molecular Weight

Molecular Weight on EC 3.4.21.B7 - mannan-binding lectin-associated serine protease 1

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
29000
30000
-
SDS-PAGE and Western blot analysis, partially activated form
31000
-
1 * 66000 + 1 * 31000, activated form
32000
-
1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions
34000
-
1 * 32000 + 1 * 34000, SDS-PAGE, reducing conditions
38000
-
calculated molecular mass of the MASP-1 CUB-EGF fragment in the presence of Ca2+
50000
-
SDS-PAGE, non-reducing conditions
58000
-
1 * 58000 + 1 * 30000-32000, SDS-PAGE
600000
large enzyme complexes in plasma, gel filtration
65000
-
SDS-PAGE
66000
-
1 * 66000 + 1 * 31000, activated form
70000
75000
x * 75000, SDS-PAGE
76980
-
calculated from sequence analysis
77040
calculated from nucleic acid sequence
81000
-
x * 81000, SDS-PAGE
87000
-
MASP-1, gel filtration
90000
93000
-
unactivated proenzyme