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Literature summary for 3.4.21.B7 extracted from

  • Jenny, L.; Dobo, J.; Gal, P.; Schroeder, V.
    MASP-1 of the complement system promotes clotting via prothrombin activation (2015), Mol. Immunol., 65, 398-405.
    View publication on PubMed
Search for more literature for 3.4.21.B7

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
proform mannan-binding lectin-associated serine protease 2 + H2O Homo sapiens enzyme MASP-1 is the main activator of MASP-2 mature mannan-binding lectin-associated serine protease 2 + ?
-
 ?
proform protease activated receptor 4 + H2O Homo sapiens activation mature protease activated receptor 4 + ?
-
 ?
prothrombin + H2O Homo sapiens enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393 thrombin a + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48740
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
proform mannan-binding lectin-associated serine protease 2 + H2O activation Homo sapiens mature mannan-binding lectin-associated serine protease 2 + ?
-
 ?
proform mannan-binding lectin-associated serine protease 2 + H2O enzyme MASP-1 is the main activator of MASP-2 Homo sapiens mature mannan-binding lectin-associated serine protease 2 + ?
-
 ?
proform protease activated receptor 4 + H2O activation Homo sapiens mature protease activated receptor 4 + ?
-
 ?
prothrombin + H2O enzyme MASP-1 cleaves prothrombinat three cleavage sites, MASP-1 gives rise to an alternative active form of thrombin by cleaving at the cleavage site R393 Homo sapiens thrombin a + ?
-
 ?
prothrombin + H2O enzyme MASP-1 cleaves prothrombinant three cleavage sites Homo sapiens thrombin a + ?
-
 ?

Synonyms

Synonyms Comment Organism
MASP-1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme MASP-1 is part of the lectin pathway of the complement system and is able to induce and promote clot formation, MASP-1-induced clotting is dependent on prothrombin Homo sapiens