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3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.26 prolyl oligopeptidase

Turnover Number

Turnover Number on EC 3.4.21.26 - prolyl oligopeptidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1 - 1.1
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
0.6 - 0.9
2-aminobenzoyl-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
0.03 - 7.22
2-aminobenzoyl-Glu-Gly-Phe-Ser-Pro-Phe(NO2)-Arg-Ala
1.7
2-aminobenzoyl-Glu-Phe-Ser-Pro-Phe(NO2)-Arg-Ala
-
1.82 - 2.94
2-aminobenzoyl-Gly-Glu-Ser-Pro-Phe(NO2)-Arg-Ala
3.2
2-aminobenzoyl-Gly-Phe-Arg-Pro-Phe(NO2)-Arg-Ala
-
2.4
2-aminobenzoyl-Gly-Phe-Glu-Pro-Phe(NO2)-Arg-Ala
-
3.3 - 5.38
2-aminobenzoyl-Gly-Phe-Gly-Pro-Phe-Gly-Phe(NO2)-Ala-NH2
1.4
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.5, 37°C, recombinant wild-type enzyme
1.4 - 1.5
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
0.6
2-aminobenzoyl-Gly-Phe-Ser-Pro-Phe-Arg-Ser-Ser-Arg-Ile-Gly-GLu-Ile-Lys-Glu-Glu-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.5, 37°C, recombinant wild-type enzyme and mutant C255T
1.4 - 7.9
2-aminobenzoyl-Gly-Pro-Gln-N-(2,4-dinitrophenyl)ethylenediamine
4
2-aminobenzoyl-Gly-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.5, 37°C, recombinant wild-type enzyme
6
2-aminobenzoyl-Gly-Pro-Phe-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.5, 37°C, recombinant wild-type enzyme
3.5
2-aminobenzoyl-Gly-Ser-Pro-Phe-Arg-Gln-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.5, 37°C, recombinant wild-type enzyme
0.97 - 1.31
Abz-Gly-L-Phe-L-Arg-L-Pro-L-Phe(NO2)-L-Arg-L-Ala
15.9
Ala-Gly-Pro-beta-naphthylamide
Lyophyllum cinerascens
-
-
0.079
Ala-Pro-4-nitroanilide
-
pH 7.5, 85°C
0.079
Ala-Pro-p-nitroanilide
-
pH 7.5, 85°C
0.85
angiotensin I
-
-
0.03 - 16.9
Arg-Pro-4-nitroanilide
0.03
Arg-Pro-p-nitroanilide
-
pH 7.5, 85°C
0.073
Asp-Pro-4-nitroanilide
-
pH 7.5, 85°C
0.073
Asp-Pro-p-nitroanilide
-
pH 7.5, 85°C
2.5
benzyloxycarbonyl-Ala-Ala-4-nitroanilide
-
pH 7.5, 85°C
5.9
benzyloxycarbonyl-Ala-Ala-beta-naphthylamide
-
-
2.5
benzyloxycarbonyl-Ala-Ala-p-nitroanilide
-
pH 7.5, 85°C
2.7
benzyloxycarbonyl-Ala-Ala-p-nitrophenol
-
-
0.82 - 192
benzyloxycarbonyl-Ala-Gly-Pro-beta-naphthylamide
38.2
benzyloxycarbonyl-Ala-Gly-Pro-p-nitrophenol
-
enzyme from kidney
17.9
benzyloxycarbonyl-Ala-Pro-4-nitroanilide
-
pH 7.5, 85°C
4.2
benzyloxycarbonyl-Ala-Pro-beta-naphthylamide
-
-
17.9 - 126
benzyloxycarbonyl-Ala-Pro-p-nitroanilide
61
benzyloxycarbonyl-Ala-Pro-p-nitrophenol
-
enzyme from kidney
2 - 38
benzyloxycarbonyl-D-Ala-Gly-Pro-beta-naphthylamide
30
benzyloxycarbonyl-D-Ala-Gly-Pro-p-nitrophenol
-
enzyme from kidney
0.147
benzyloxycarbonyl-D-Ala-Pro-beta-naphthylamide
-
-
2.05 - 85.8
benzyloxycarbonyl-Gly-Gly-Pro-p-nitrophenol
60 - 162
benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide
26.6
benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin
-
at pH 8.0 and 37°C
4.7
benzyloxycarbonyl-Gly-L-Pro-beta-naphthylamide
-
pH 7.4, 37°C, enzyme from thioglycollate-elicited macrophage
0.95 - 115
benzyloxycarbonyl-Gly-Pro-4-methylcoumaryl-7-amide
1.26 - 240
Benzyloxycarbonyl-Gly-Pro-Ala
0.0151 - 169
benzyloxycarbonyl-Gly-Pro-beta-naphthylamide
1.52 - 2.94
benzyloxycarbonyl-Gly-Pro-D-Ala
0.67 - 6.08
benzyloxycarbonyl-Gly-Pro-D-Leu
1.05 - 26
Benzyloxycarbonyl-Gly-Pro-Leu
13.2 - 520
benzyloxycarbonyl-Gly-Pro-Leu-Ala
5.67 - 1600
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala
0.031 - 520
Benzyloxycarbonyl-Gly-Pro-Leu-Gly
34 - 1000
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Ala
25
benzyloxycarbonyl-Gly-Pro-Leu-Gly-D-Ala
-
enzyme from kidney
2 - 700
benzyloxycarbonyl-Gly-Pro-Leu-Gly-Gly
0.4 - 53.3
Benzyloxycarbonyl-Gly-Pro-Leu-Gly-Pro
3.8 - 16.9
benzyloxycarbonyl-Gly-Pro-p-nitroanilide
0.021 - 102
benzyloxycarbonyl-Gly-Pro-p-nitrophenol
3.2 - 180
Benzyloxycarbonyl-Gly-Pro-Phe
0.028 - 108
benzyloxycarbonyl-Gly-Pro-SBzl
8.9
benzyloxycarbonyl-Pro-p-nitrophenol
-
enzyme from kidney
0.0012 - 0.072
calcitonin gene-related peptide
-
0.06
Gly-Pro-4-nitroanilide
-
pH 7.5, 85°C
0.06
Gly-Pro-p-nitroanilide
-
pH 7.5, 85°C
0.23 - 0.58
IWGIGCNPWTAEHVDQTLASGNDIC
107.4 - 139.4
L-Ala-L-Ala-L-Pro-4-nitroanilide
4.9 - 570
L-Leu-4-nitroanilide
550 - 4300
L-Phe-4-nitroanilide
6.1
N-benzyloxycarbonyl-Gly-Pro-Ala
-
-
32.3
N-benzyloxycarbonyl-Gly-Pro-Leu-Gly
-
-
22.2
N-succinyl-Ala-Pro-4-nitroanilide
pH 7.5, 80°C, recombinant enzyme
28.1 - 48.7
N-succinyl-Gly-L-Pro-L-Leu-Gly-L-Pro-7-amido-4-methylcoumarin
29.2
Nalpha-benzyl-Gly-Pro-Leu-Gly
-
-
17.6
Nalpha-benzyloxycarbonyl-Gly-Pro-Leu-Gly
-
-
14.4
thyrotropin-releasing hormone
-
-
105.7 - 240
Z-Gly-L-Pro-4-nitroanilide
505
Z-Gly-Pro-4-nitroanilide
-
75 - 93
Z-L-Ala-L-Ala-L-Ala-L-Pro-4-nitroanilide
additional information
benzyloxycarbonyl-Gly-Pro-Leu-D-Ala