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3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.26 prolyl oligopeptidase

pH Optimum

pH Optimum on EC 3.4.21.26 - prolyl oligopeptidase

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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5
-
isoform S28B
4.6
-
assay at
5.7 - 6.3
-
succinyl-Gly-Pro-7-amido-4-methylcoumarin
5.8
-
enzyme from skin
6.5
-
reaction with 2-aminobenzoyl-FPQ-(N-(2,4-dinitrophenyl)ethylenediamine), and a second lower optimum at pH 8.0
6.5 - 7.5
-
-
7 - 8
7.2
-
thyrotropin releasing hormone
7.2 - 7.5
7.4
-
assay at
7.4 - 7.5
-
assay at
7.4 - 7.6
-
enzyme from hypophysis
7.5 - 8
7.8
-
enzyme from kindney
7.8 - 8
-
benzyloxycarbonylglycycl-prolyl-leucyl-glycinamide, benzyloxycarbonyl-glycyl-proline beta-naphthylamide
8 - 10
-
between 20°C and 35°C, above pH 10, the activity declines sharply
8 - 8.5
-
enzyme from serum
9
-
reaction with 2-aminobenzoyl-RPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
additional information
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