3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

3.4.21.26

dipeptidyl

stroma

cancer-associated

aminopeptidase

neuropeptides

endopeptidases

neurotensin

proline-containing

fapis

biodistribution

myofibroblasts

flavobacterium

celiac

beta-propeller

bradykinin

trh

dppiv

meningosepticum

3.4.14.5

18f-fdg

theranostic

exopeptidase

pyroglutamyl

phosphoramidon

amanita

amnesia

carcinoma-associated

peptidase-iv

pharmacology

ac-sdkp

seven-bladed

gluten-free

suvmean

gliadin

n-acetyl-seryl-aspartyl-lysyl-proline

bispecific

acylpeptide

medicine

nutrition

food industry

drug development

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.26 prolyl oligopeptidase

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Results	in table
15	Activating Compound
1921	AA Sequence
28	Application
1	CAS Registry Number
40	Cloned(Commentary)
12	Crystallization (Commentary)
1563	Disease/ Diagnostics
8	Expression
34	General Information
6	General Stability
294	IC50 Value
923	Inhibitors
45	kcat/KM [mM/s]
96	Ki Value [mM]
178	KM Value [mM]
86	Localization
17	Metals/Ions
88	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
249	Organism
2	Oxidation Stability
38	PDB ID
82	pH Optimum
20	pH Range
12	pH Stability
18	pI Value
7	Posttranslational Modification
55	Protein Variants
58	Purification (Commentary)
27	Reaction
12	Reaction Type
249	Reference
1	Renatured (Commentary)
386	Source Tissue
77	Specific Activity [micromol/min/mg]
3	Storage Stability
733	Substrates and Products (Substrate)
65	Subunits
285	Synonyms
44	Temperature Optimum [°C]
3	Temperature Range [°C]
21	Temperature Stability [°C]
155	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.26 - prolyl oligopeptidase

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0.000109

(+)-gallocatechin

Elizabethkingia meningoseptica

IC50: 0.000109 mM, expected to be useful for preventing and curing of Alzheimers disease

649523

0.0281

(-)-epicatechin

Elizabethkingia meningoseptica

IC50: 0.0281 mM, noncompetitive inhibition

650842

10.2

(-)-epicatechin gallate

Elizabethkingia meningoseptica

IC50: 10.2 mM, expected to be useful for preventing and curing of Alzheimers disease

649523

0.000142

(-)-epigallocatechin gallate

Elizabethkingia meningoseptica

IC50: 0.000142 mM, expected to be useful for preventing and curing of Alzheimers disease

649523

0.0989

(1R,3S,4S,5S)-1,3,4-tris(acetyloxy)-5-([(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoyl]oxy)cyclohexanecarboxylic acid

Homo sapiens

pH and temperature not specified in the publication

732660

0.023

(1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid

Homo sapiens

pH and temperature not specified in the publication

732660

0.0125

(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid

Homo sapiens

pH and temperature not specified in the publication

732660

0.198

(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid

Homo sapiens

pH and temperature not specified in the publication

732660

0.028

(2E)-3-[3,4-bis(acetyloxy)phenyl]prop-2-enoic acid

Homo sapiens

pH and temperature not specified in the publication

732660

0.00003

(2S)-1-(4-phenylbutanoyl)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine

Sus scrofa

P23687

693573

0.000048

(2S)-1-octanoyl-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine

Sus scrofa

P23687

693573

0.00000045

(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbaldehyde

Canis lupus familiaris

brain

709476

0.0000012

(2S)-1-[1-(2,3-dihydro-1H-inden-2-ylacetyl)-L-prolyl]pyrrolidine-2-carbonitrile

Canis lupus familiaris

brain

709476

0.0000087

(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbaldehyde

Sus scrofa

P23687

kidney

709476

0.000000023

(2S)-1-[1-(4-phenylbutanoyl)-L-prolyl]pyrrolidine-2-carbonitrile

Sus scrofa

P23687

709476

0.000002

(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indole

Homo sapiens

691291

0.000034

(3S)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000031

(3S)-6-[(2,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000064

(3S)-6-[(2,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000018

(3S)-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000022

(3S)-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000004

(3S)-6-[(3,5-difluorobenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000022

(3S)-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.00006

(3S)-6-[(4-tert-butylbenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.00027

(3S)-6-[(4-tert-butylbenzyl)oxy]-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000011

(3S)-8-(phenylsulfonyl)-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000584

(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-(2,2,2-trifluoroethoxy)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000028

(3S)-8-acetyl-3-(pyrrolidin-1-ylcarbonyl)-6-[[4-(trifluoromethyl)benzyl]oxy]-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000002

(3S)-8-acetyl-6-(2-phenylethyl)-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000028

(3S)-8-acetyl-6-[(3,4-dichlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000007

(3S)-8-acetyl-6-[(3,4-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000022

(3S)-8-acetyl-6-[(3,5-difluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000008

(3S)-8-acetyl-6-[(3-chloro-4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000048

(3S)-8-acetyl-6-[(4-chlorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000343

(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(1H-pyrazol-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000053

(3S)-8-acetyl-6-[(4-fluorobenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.00014

(3S)-8-acetyl-6-[(4-methoxybenzyl)oxy]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.00003

(3S)-8-acetyl-6-[2-(4-fluorophenyl)ethyl]-3-(pyrrolidin-1-ylcarbonyl)-2,3-dihydroindolizin-5(1H)-one

Homo sapiens

691291

0.000002

(3S)-N-benzyl-3-[[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]carbonyl]-3,4-dihydroisoquinoline-2(1H)-carboxamide

Trypanosoma brucei brucei

Q6HA27

709834

0.000011

(4R)-3-octanoyl-4-(pyrrolidin-1-ylcarbonyl)-1,3-thiazolidine

Sus scrofa

P23687

693573

0.0143

(5R,7S,8S,9S)-8,9-dihydroxy-2,2-dimethyl-4-oxo-1,3-dioxaspiro[4.5]dec-7-yl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

Homo sapiens

pH and temperature not specified in the publication

732660

0.0031

(6S)-1,3-dichloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000007

(6S)-1-chloro-3-(cyclohexylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.004

(6S)-1-chloro-3-(naphthalen-2-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.0008

(6S)-1-chloro-3-(pyridin-4-ylmethoxy)-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.001

(6S)-1-chloro-3-phenoxy-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.00008

(6S)-1-chloro-3-[(2-phenylethyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000034

(6S)-1-chloro-3-[(3,4-dichlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000015

(6S)-1-chloro-3-[(3,4-difluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000055

(6S)-1-chloro-3-[(3,4-difluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000043

(6S)-1-chloro-3-[(3-chloro-4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.00003

(6S)-1-chloro-3-[(3-chlorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000017

(6S)-1-chloro-3-[(4-fluorobenzyl)amino]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000012 - 0.00004

(6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

2 entries

0.0022

(6S)-1-chloro-3-[2-(3,4-dichlorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.0009

(6S)-1-chloro-3-[2-(4-fluorophenyl)ethoxy]-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.00004

(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[(2,3,5-trifluorobenzyl)oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.00025

(6S)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-3-[[4-(trifluoromethyl)benzyl]oxy]-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.000012

(6S)-3-(benzylamino)-1-chloro-6-(pyrrolidin-1-ylcarbonyl)-7,8-dihydropyrrolo[1,2-a]pyrazin-4(6H)-one

Homo sapiens

691291

0.12

(E)-4-(3-(2-(methoxycarbonyl)pyrrolidin-1-yl)-3-oxoprop-1-enyl)-1,2-phenylene-diacetate

Homo sapiens

pH and temperature not specified in the publication

732660

0.1057

(E)-methyl 1-(3-(3,4-dihydroxyphenyl)acryloyl)pyrrolidine-2-carboxylate

Homo sapiens

pH and temperature not specified in the publication

732660

0.21

(E)-methyl 1-(3-(3-(3,4-dihydroxyphenyl)acryloyloxy)-1,4,5-trihydroxycyclohexanecarbonyl)pyrrolidine-2-carboxylate

Homo sapiens

pH and temperature not specified in the publication

732660

0.00000029 - 0.00001

(S)-1-((S)-1-(4-phenylbutanoyl)-pyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile

2 entries

0.00017

1,2,3,4,6-penta-O-galloyl-beta-D-glucose

Flavobacterium sp.

IC50: 170 nM

650847

0.000025

1,2,3,6-tetra-O-galloyl-beta-D-glucose

Flavobacterium sp.

IC50: 25 nM

650847

0.00044

1,2,6-tri-O-galloylglucose

Elizabethkingia meningoseptica

IC50: 0.00044 mM, noncompetitive inhibition

650842

0.0000314

1,2,6-trigalloyl glucopyranoside

Homo sapiens

683100

0.000002

1,2-oxazolidin-2-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone

Rattus norvegicus

rat cortex

709476

0.051

1,3-dibenzyl-4-(benzylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.214

1,3-dicyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.00000088

1-(3-oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]propyl)-3-phenylquinoxalin-2(1H)-one

Sus scrofa

P23687

693573

0.000059

1-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-3-phenylquinoxalin-2(1H)-one

Sus scrofa

P23687

693573

0.00051

1-(4-phenylbutanoyl)-2(S)-(pyridine-2-carbonyl)pyrrolidine

Sus scrofa

pH 7.0, 30°C

683228

0.000003

1-(4-phenylbutanoyl)-2(S)-(thiophene-2-carbonyl)pyrrolidin

Sus scrofa

pH 7.0, 30°C

683228

0.00011

1-(cyclopent-1-en-1-ylcarbonyl)-N-(2-phenylethyl)-L-prolinamide

Sus scrofa

P23687

brain

709476

0.044

1-(cyclopent-1-enecarbonyl)-D-proline benzylamide

Sus scrofa

pH 7.0, 30°C

683228

0.00021

1-(cyclopent-1-enecarbonyl)-L-proline benzylamide

Sus scrofa

pH 7.0, 30°C

683228

0.0001

1-(cyclopent-1-enecarbonyl)-L-proline phenethylamide

Sus scrofa

pH 7.0, 30°C

683228

0.122

1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.037

1-benzyl-3-cyclohexyl-4-(cyclohexylamino)-5-(methoxymethyl)-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.0000021

1-[(2R,5S)-2-(propan-2-yl)-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(pyridin-3-yl)butan-1-one

Sus scrofa

P23687

brain

709476

0.0000012

1-[(2R,5S)-2-tert-butyl-5-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-phenylbutan-1-one

Sus scrofa

P23687

brain

709476

0.000054

1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone

Canis lupus familiaris

brain

709476

0.0000054

1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]ethanone

Canis lupus familiaris

brain

709476

0.000034

1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-4-(thiophen-2-yl)butan-1-one

Canis lupus familiaris

brain

709476

0.00002

1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]octan-1-one

Rattus norvegicus

rat brain

709476

0.00000088

1-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-3-phenylquinoxalin-2(1H)-one

Rattus norvegicus

rat brain

709476

0.0571

1-[[(2S)-1-(4-phenylbutanoyl)pyrrolidin-2-yl]carbonyl]pyrrolidin-2-one

Canis lupus familiaris

brain

709476

0.000059

2(S)-(cyclohex-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine

Sus scrofa

pH 7.0, 30°C

683228

0.000003

2(S)-(cyclopent-1-enecarbonyl)-1-(4-phenylbutanoyl)pyrrolidine

Sus scrofa

pH 7.0, 30°C

683228

0.0000052

2(S)-(furan-2-carbonyl)-1-(4-phenylbutanoyl)pyrrolidine

Sus scrofa

pH 7.0, 30°C

683228

0.00052

2,3-dihydro-1H-inden-2-yl[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]methanone

Canis lupus familiaris

brain

709476

0.0000027

2,3-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone

Rattus norvegicus

rat cortex

709476

0.0000024

2,5-dihydro-1H-pyrrol-1-yl[(2S,3aS,7aS)-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]octahydro-1H-indol-2-yl]methanone

Rattus norvegicus

rat cortex

709476

0.00001

2-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethanone

Canis lupus familiaris

brain

709476

0.00000081

2-(3-[(2S)-4,4-difluoro-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]-3-oxopropyl) isoindole-1,3(2H)-dione

Sus scrofa

P23687

693573

0.00004

2-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-1H-isoindole-1,3(2H)-dione

Sus scrofa

P23687

693573

0.000003

2-[2-oxo-2-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]ethyl]-1H-isoindole-1,3(2H)-dione

Rattus norvegicus

rat brain

709476

0.00000081

2-[2-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Rattus norvegicus

rat brain

709476

0.000003

2-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-1H-isoindole-1,3(2H)-dione

Sus scrofa

P23687

693573

0.000013

3,3-dimethyl glutaric acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 13 nM

652739

0.003

3,5,4'-trihydroxystilbene 4'-O-beta-D-(2-O-galloyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.003 mM, noncompetitive inhibition

650842

0.0149

3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.0149 mM, noncompetitive inhibition

650842

0.0229

3,5,4'-trihydroxystilbene 4'-O-beta-D-glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.0229 mM, noncompetitive inhibition

650842

0.00046

3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-5(R)-tert-butyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 460 nM

650529

0.000018

3-(2(S)-benzoyl-pyrrolidine-1-carbonyl)-benzoyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 18 nM

650529

0.000036

3-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-1-one

Canis lupus familiaris

brain

709476

0.000041

3-(4-oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin-1-yl]butyl)-5,5-diphenylimidazolidine-2,4-dione

Sus scrofa

P23687

693573

0.147

3-benzyl-4-(benzylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.129

3-cyclohexyl-4-(cyclohexylamino)-1-ethyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.14

3-cyclohexyl-4-(cyclohexylamino)-1-methyl-5-[(prop-2-en-1-yloxy)carbonyl]-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.194

3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-(4-methylphenyl)-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.072

3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-methyl-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.169

3-cyclohexyl-4-(cyclohexylamino)-5-(methoxycarbonyl)-1-[(1S)-1-phenylethyl]-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.00000107

3-cyclohexyl-N-[(2S)-1-oxo-3-phenyl-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]propan-2-yl]propanamide

Sus scrofa

P23687

kidney

709476

0.00044

3-O-galloylepigallocatechin-(4-8)-epigallocetechin 3-O-gallate

Flavobacterium sp.

IC50: 440 nM

650847

0.000041

3-[3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl]-5,5-diphenylimidazolidine-2,4-dione

Rattus norvegicus

rat brain

709476

0.00006

4-(2,3-dihydro-1H-inden-2-yl)-1-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-1-one

Canis lupus familiaris

brain

709476

0.065 - 0.133

4-(4-chlorophenyl)-8-(ethoxycarbonyl)-5-methyl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide

2 entries

0.0105

4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2,6-di-O-galloyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.0105 mM, noncompetitive inhibition

650842

0.00069

4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 690 nM, noncompetitive inhibition

650842

0.082

4-(4-hydroxyphenyl)-2-butanone 4'-O-beta-D-(6-O-galloyl-2-O-cinnamoyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.082 mM, noncompetitive inhibition

650842

0.000783

4-([[(3S)-8-acetyl-5-oxo-3-(pyrrolidin-1-ylcarbonyl)-1,2,3,5-tetrahydroindolizin-6-yl]oxy]methyl)benzonitrile

Homo sapiens

691291

4-phenyl-1-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]butan-1-one

Bos taurus

brain, value above

709476

0.000005

4-phenyl-1-[(2S)-2-[[(2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidin-1-yl]butan-1-one

Sus scrofa

P23687

kidney

709476

0.00055

4-phenyl-1-[(3S)-3-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]butan-1-one

Homo sapiens

709476

0.000021

4-phenyl-1-[(4R)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one

Canis lupus familiaris

brain

709476

0.102

4-phenyl-1-[(4S)-4-(1,3-thiazolidin-3-ylcarbonyl)-1,3-thiazolidin-3-yl]butan-1-one

Canis lupus familiaris

brain

709476

0.00023

4-phenyl-1-[2-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one

Sus scrofa

P23687

brain

709476

0.0000013

4-phenyl-1-[5-(pyrrolidin-1-ylcarbonyl)cyclopent-1-en-1-yl]butan-1-one

Sus scrofa

P23687

brain

709476

0.00026

4-phenylbutanoyl-2(S)-(2-oxocyclopentanecarbonyl)-pyrrolidine

Sus scrofa

IC50: 260 nM

650521

0.024

4-phenylbutanoyl-2(S)-(3-phenylpropionyl)pyrrolidine

Sus scrofa

IC50: 0.024 mM

650521

0.0011

4-phenylbutanoyl-2(S)-(cyclohexanecarbonyl)pyrrolidine

Sus scrofa

IC50: 1100 nM

650521

0.00003

4-phenylbutanoyl-2(S)-(cyclopentanecarbonyl)pyrrolidine

Sus scrofa

IC50: 30 nM

650521

0.0036

4-phenylbutanoyl-2(S)-(phenylacetyl)pyrrolidine

Sus scrofa

IC50: 3600 nM

650521

0.000023

4-phenylbutanoyl-2(S)-benzylpyrrolidine

Sus scrofa

IC50: 23 nM

650521

0.00062

4-phenylbutanoyl-2(S)-isobutanoylpyrrolidine

Sus scrofa

IC50: 620 nM

650521

0.00000015

4-phenylbutanoyl-5(R)-methyl-L-Pro-2(S)-(hydroxyacetyl)pyrrolidine

Sus scrofa

IC50: 0.15 nM

650529

0.00000071

4-phenylbutanoyl-5(R)-methyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 0.71 nM

650529

0.00000026

4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine

Sus scrofa

IC50: 0.26 nM

650529

0.0000012

4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 1.2 nM

650529

0.00000026

4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine

Sus scrofa

P23687

at 25°C between pH 5.5 and 9.5

731374

0.0000014

4-phenylbutanoyl-5(S)-methyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 1.4 nM

650529

0.00000024

4-phenylbutanoyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine

Sus scrofa

IC50: 0.24 nM

650529

0.0000022

4-phenylbutanoyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 2.2 nM

650529

0.0000002

4-phenylbutanoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine

Sus scrofa

IC50: 0.2 nM

650521

0.00017

4-phenylbutanoyl-L-prolyl-2(S)-acetylpyrrolidine

Sus scrofa

IC50: 170 nM

650521

0.00021

4-phenylbutanoyl-L-prolyl-2(S)-benzoylpyrrolidine

Sus scrofa

IC50: 210 nM

650521

0.0000002

4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine

Sus scrofa

P23687

at 25°C between pH 5.5 and 9.5

731374

0.124

5-(4-chlorophenyl)-9-(ethoxycarbonyl)-6-methyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide

Homo sapiens

691816

0.099

5-(methoxycarbonyl)-3-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-1-methyl-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.201

5-cyano-3-cyclohexyl-4-(cyclohexylamino)-1-methyl-1H-3,1-benzimidazol-3-ium iodide

Homo sapiens

691816

0.075

8-(ethoxycarbonyl)-5-methyl-4-naphthalen-1-yl-2,3-dihydrofuro[3,2-c]quinolin-5-ium iodide

Homo sapiens

691816

0.135

9-(ethoxycarbonyl)-6-methyl-5-phenyl-3,4-dihydro-2H-pyrano[3,2-c]quinolin-6-ium iodide

Homo sapiens

691816

0.0071

acetyl-5(R)-tert-butyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 7100 nM

650529

0.000068

adipic acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 68 nM

652739

0.337

argemonine

Homo sapiens

at pH 7.4 and 37°C

753619

0.013

ARI-3099

Homo sapiens

at 25°C, pH not specified in the publication

732303

0.0000013

ARI-3531

Homo sapiens

at 25°C, pH not specified in the publication

732303

0.0123

Baicalin

Homo sapiens

709476

0.000066

benzoyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 66 nM

652739

0.00000034

benzyl (2S)-2-([(2S)-2-[(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)carbonyl]pyrrolidin-1-yl]carbonyl)pyrrolidine-1-carboxylate

Trypanosoma brucei brucei

Q6HA27

709834

4.9

benzyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate

Homo sapiens

pH and temperature not specified in the publication

732660

0.014

benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate

Homo sapiens

human peripheral blood mononuclear cells

709476

0.0000021

benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate

Trypanosoma brucei brucei

Q6HA27

709834

0.0000014

benzyl (2S)-2-[[(2S)-2-([5-[(benzyloxy)methyl]-4,5-dihydro-1,2-oxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate

Trypanosoma brucei brucei

Q6HA27

709834

0.000002

benzylcarbamoyl-5(R)-tert-butyl-L-prolyl-pyrrolidine

Sus scrofa

IC50: 2.0 nM

650529

0.00000083

benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine

Sus scrofa

P23687

at 25°C between pH 5.5 and 9.5

731374

0.0000004

benzyloxycarbonyl-L-Pro-L-prolinal

Sus scrofa

IC50: 0.4 nM

650521

0.00000033

benzyloxycarbonyl-Pro-L-prolinal

Sus scrofa

IC50: 0.33 nM

652739

0.142 - 0.145

Berberine

3 entries

0.128

berberine chloride

Setaria cervi

at pH 8.0 and 37°C

752673

0.0231

bixanin

Homo sapiens

683100

0.0000022

Boc-5(R)-tert-butyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 2.2 nM

650529

0.0000092

Boc-5(S)-tert-butyl-L-Pro-pyrrolidine

Sus scrofa

IC50: 9.2 nM

650529

0.00204 - 0.00294

Boc-Asn-Phe-Pro-aldehyde

2 entries

0.000029

Boc-L-Pro-pyrrolidine

Sus scrofa

IC50: 29 nM

650529

0.6028

boldine

Homo sapiens

pH and temperature not specified in the publication

754864

0.002

calcitonin gene-related peptide

Mus musculus

707485

0.056

californidine

Homo sapiens

at pH 7.4 and 37°C

753619

0.152

canadine

Homo sapiens

at pH 7.4 and 37°C

753619

0.00000083

caproyl-L-Pro-((2S)-hydroxyacetyl)pyrrolidine

Homo sapiens

683389

0.0028

cis-3,5,4'-trihydroxystilbene 4'-O-beta-D-(6-O-galloyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.0028 mM, noncompetitive inhibition

650842

0.289

corynoline

Homo sapiens

at pH 7.4 and 37°C

753619

0.128

corypalmine

Homo sapiens

at pH 7.4 and 37°C

753619

0.0000003

cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide

Sus scrofa

P23687

at 25°C between pH 5.5 and 9.5

731374

0.099

dihydrosanquinarine

Homo sapiens

at pH 7.4 and 37°C

753619

galanthamine

Homo sapiens

IC50 above 1.0 mM, pH and temperature not specified in the publication

754864

0.00939

gallic acid 4-O-beta-D-(6-O-galloyl)glucopyranoside

Elizabethkingia meningoseptica

IC50: 0.00939 mM, noncompetitive inhibition

650842

0.00062

ginkgolic acid

Homo sapiens

683100

0.000048

glutaric acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 48 nM

652739

isocorydine

Homo sapiens

IC50 above 1.0 mM, pH and temperature not specified in the publication

754864

0.000054

isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 54 nM

652752

0.00064

isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine (L-proline methyl ester) amide

Sus scrofa

IC50: 640 nM

652752

0.00000061

isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide

Sus scrofa

IC50: 0.61 nM, log P: 0.2, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.000014

isophthalic acid 2(S)-(cyclopentylcarbonyl)pyrrolidine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 14 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.00000072

isophthalic acid 2(S)-(cylcohexanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide

Sus scrofa

IC50: 0.72 nM

652752

0.0000011

isophthalic acid 2(S)-(cylcopentanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide

Sus scrofa

IC50: 1.1 nM, log P: 0.8, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.0000012

isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide

Sus scrofa

IC50: 1.2 nM

652752

0.0000042

isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide

Sus scrofa

IC50: 4.2 nM, log P: -0.6, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.000065

isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 65 nM

652752

0.0000013

isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide

Sus scrofa

IC50: 1.3 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.000018

isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 18 nM

652752

0.0000016

isophthalic acid 2(S)-isobutanoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide

Sus scrofa

IC50: 1.6 nM, log P: 0.3, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.000026

isophthalic acid bis(L-prolyl-pyrrolidine) amide

2 entries

0.000078

isophthalic acid bis-2(S)-(cyclopentanecarbonyl)pyrrolidine amide

Sus scrofa

IC50: 78 nM, log P: 2.7, the log P value is a first prediction of the blood-brain barrier penetrability

652752

0.00000039

isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 0.39 nM

652752

0.0000015

isophthalic acid L-prolyl-2(S)-cyanopyrrolidine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 1.5 nM

652739, 652752

0.0000013

isophthalic acid L-prolyl-pyrrolidine L-prolyl-L-prolinal amide

Sus scrofa

IC50: 1.3 nM

652739, 652752

0.000031

isophthalic acid L-prolylbenzylamine L-prolyl-pyrrolidine amide

Sus scrofa

IC50: 31 nM

652752

0.0000002 - 0.00000083

JTP-4819

2 entries

0.00114

kinapsin-24

Homo sapiens

683100

0.00000015

KYP-2047

Homo sapiens

wild type enzyme, at pH 8.0 and 25°C

731346

0.5224

laurotetanine

Homo sapiens

pH and temperature not specified in the publication

754864

0.0265

licuroside

Elizabethkingia meningoseptica

IC50: 0.0265 mM, noncompetitive inhibition

650842

0.0000426

macranganin

Homo sapiens

683100

0.003

methyl (1R,3S,4S,5S)-3-[[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylate

Homo sapiens

pH and temperature not specified in the publication

732660

0.005

methyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

Homo sapiens

pH and temperature not specified in the publication

732660

0.2

N-ethylmaleimide

Coprinopsis clastophylla

at pH 8.0 and 37°C

732333

0.135 - 0.1354

N-methyllaurotetanine

2 entries

0.0000042

N-[(2S)-1-[(2S)-2-formylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-4-phenylbutanamide

Bos taurus

brain

709476

0.00000105

N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-(piperidin-1-ylcarbonyl)pyrrolidin-1-yl]butan-2-yl]-3-phenoxybenzamide

Sus scrofa

P23687

kidney

709476

0.3204

norisocorydine

Homo sapiens

pH and temperature not specified in the publication

754864

0.5897

pallidine

Homo sapiens

pH and temperature not specified in the publication

754864

0.021

phthalic acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 0.021 mM

652739

0.687

platycerine

Homo sapiens

at pH 7.4 and 37°C

753619

0.392 - 0.3923

reticuline

2 entries

0.022

rhodionin

Flavobacterium sp.

IC50: 0.022 mM

650847

0.041

rhodiosin

Flavobacterium sp.

IC50: 0.041 mM

650847

0.00084

rosiridin

Flavobacterium sp.

IC50: 840 nM

650847

0.0524 - 0.0637

rosmarinic acid

2 entries

0.0000267

rugosin E

Homo sapiens

683100

0.1431

sinoacutine

Homo sapiens

pH and temperature not specified in the publication

754864

0.00077

staurosporine

Homo sapiens

683100

0.000083 - 0.000092

SUAM 14746

2 entries

0.000002 - 0.0021

SUAM-1221

7 entries

0.000077

succinic acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 77 nM

652739

0.000081

terephthalic acid bis(L-prolyl-pyrrolidine) amide

Sus scrofa

IC50: 81 nM

652739

0.000029

tert-butyl (2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidine-1-carboxylate

Sus scrofa

P23687

brain

709476

0.0878

Tyr-Pro-Ile-Pro-Phe

Elizabethkingia meningoseptica

683389

0.0000016

UAMC-00021

2 entries

0.017

Val-Glu-Ile-Pro-Glu

Elizabethkingia meningoseptica

683389

0.0034

verbascoside

Homo sapiens

pH and temperature not specified in the publication

732660

0.00049 - 0.0086

Y-29794 oxalate

2 entries

0.0031 - 0.0061

Z-Ala-Pro-aldehyde

2 entries

0.0000032 - 0.0000168

Z-Ala-Pro-chloromethylketone

2 entries

0.0013 - 0.0024

Z-Arg-Pro-aldehyde

2 entries

0.0000029 - 0.0000048

Z-Arg-Pro-chloromethylketone

2 entries

0.0061 - 0.0076

Z-Gly-Pro-aldehyde

2 entries

0.0000014

Z-L-prolyl-L-prolinal

Homo sapiens

708508

0.003 - 0.0072

Z-Lys-Pro-aldehyde

2 entries

0.000012 - 0.00016

Z-Pro-Pro-aldehyde

2 entries

0.000733 - 0.005111

Z-Pro-Pro-aldehyde-dimethylacetal

2 entries

0.0000004 - 0.0000516

Z-Pro-prolinal

3 entries

2.75 - 2.8

Z-prolyl-prolinal

2 entries

0.0044 - 0.011

Z-Tyr-Pro-aldehyde

2 entries

0.0000023

[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1H-pyrrol-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone

Rattus norvegicus

rat cortex

709476

0.0000012

[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(pyrrolidin-1-ylcarbonyl)octahydro-1H-indol-1-yl]methanone

Rattus norvegicus

rat cortex

709476

0.000005

[(1R,2R)-2-phenylcyclopropyl][(3S)-3-(pyrrolidin-1-ylcarbonyl)-2-azabicyclo[2.2.2]oct-2-yl]methanone

Rattus norvegicus

rat cortex

709476

additional information

Elizabethkingia meningoseptica

683553