3.4.21.26: prolyl oligopeptidase

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For detailed information about prolyl oligopeptidase, go to the full flat file.

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.26 prolyl oligopeptidase

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Results	in table
15	Activating Compound
1921	AA Sequence
28	Application
1	CAS Registry Number
40	Cloned(Commentary)
12	Crystallization (Commentary)
1563	Disease/ Diagnostics
8	Expression
34	General Information
6	General Stability
294	IC50 Value
923	Inhibitors
45	kcat/KM [mM/s]
96	Ki Value [mM]
178	KM Value [mM]
86	Localization
17	Metals/Ions
88	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
249	Organism
2	Oxidation Stability
38	PDB ID
82	pH Optimum
20	pH Range
12	pH Stability
18	pI Value
7	Posttranslational Modification
55	Protein Variants
58	Purification (Commentary)
27	Reaction
12	Reaction Type
249	Reference
1	Renatured (Commentary)
386	Source Tissue
77	Specific Activity [micromol/min/mg]
3	Storage Stability
733	Substrates and Products (Substrate)
65	Subunits
285	Synonyms
44	Temperature Optimum [°C]
3	Temperature Range [°C]
21	Temperature Stability [°C]
155	Turnover Number [1/s]

Expression

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Expression on EC 3.4.21.26 - prolyl oligopeptidase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

after period of neuronal migration and differentiation decreasing expression, lowest levels in adulthood

Rattus norvegicus

O70196

709257

cytoplasmic PREP activity decreases slowly and steadily from DIV 0 throughout the growth curve until reaching confluence (between DIV 10 and 15)

Homo sapiens

-

718171

enzymatic activity of POP is highest on embryonic day 18 while the protein amounts reach their peak at birth

Rattus norvegicus

-

717528

high expression during perinatal stages

Rattus norvegicus

O70196

709257

increased enzyme activities are found in tumor cells

Homo sapiens

-

732260

PREP activity inside the nucleus increases 3fold at DIV 1 compared with its initial levels, PREP nuclearactivity decline dramatically until the cells reach confluence (right after DIV 10)

Homo sapiens

-

718171

prolyl endopeptidas activity is 2fold elevated in the lungs of cigarette smoke-exposed mice

Mus musculus

-

717073

prolyl oligopeptidase mRNA is strongly expressed in the spongiotrophoblast and labyrinth at E10.5 and E11.5 but thereafter only in the spongiotrophoblast

Mus musculus

-

718008