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Reference on EC 3.4.21.26 - prolyl oligopeptidase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walter, R.
Partial purification and characterization of post-proline cleaving enzyme: enzymatic inactivation of neurohypophyseal hormones by kidney preparations of various species
Biochim. Biophys. Acta
422
138-158
1976
Ovis aries
Manually annotated by BRENDA team
Koida, M.; Walter, R.
Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography
J. Biol. Chem.
251
7593-7599
1976
Ovis aries
Manually annotated by BRENDA team
Yoshimoto, T.; Walter, R.; Tsuru, D.
Proline-specific endopeptidase from Flavobacterium. Purification and properties
J. Biol. Chem.
255
4786-4792
1980
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Yoshimoto, T.; Simmons, W.H.; Kita, T.; Tsuru, D.
Post-proline cleaving enzyme from lamb brain
J. Biochem.
90
325-334
1981
Ovis aries
Manually annotated by BRENDA team
Hauzer, K.; Servitova, L.; Barth, T.; Jost, K.
Post-proline endopeptidase. Partial purification and characterization of the enzyme from pig kidneys
Collect. Czech. Chem. Commun.
47
1139-1148
1982
Sus scrofa
-
Manually annotated by BRENDA team
Green, G.D.J.; Shaw, E.
A prolyl endopeptidase from murine macrophages, its assay and specific inactivation
Arch. Biochem. Biophys.
225
331-337
1983
Mus musculus
Manually annotated by BRENDA team
Lin,L.N.; Brandts, J.F.
Evidence showing that a proline-specific endopeptidase has an absolute requirement for a trans peptide bond immediately preceding the active bond
Biochemistry
22
4480-4485
1983
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Yoshimoto, T.; Nishimura, T.; Kita, T.; Tsuru, D.
Post-proline cleaving enzyme (prolyl endopeptidase) from bovine brain
J. Biochem.
94
1179-1190
1983
Bos taurus
Manually annotated by BRENDA team
Yokosawa, H.; Miyata, M.; Sawada, H.; Ishii, S.
Isolation and characterization of a post-proline cleaving enzyme and its inhibitor from sperm of the ascidian, Halocynthia roretzi
J. Biochem.
94
1067-1076
1983
Halocynthia roretzi
Manually annotated by BRENDA team
Mizutani, S.; Sumi, S.; Suzuki, O.; Narita, O.; Tomoda, Y.
Post-proline endopeptidase in human placenta
Biochim. Biophys. Acta
786
113-117
1984
Homo sapiens
Manually annotated by BRENDA team
Yokosawa, H.; Nishikata, M.; Ishii, S.
N-Benzyloxycarbonyl-valyl-prolinal, a potent inhibitor of post-proline cleaving enzyme
J. Biochem.
95
1819-1821
1984
Halocynthia roretzi
Manually annotated by BRENDA team
Hauzer, K.; Barth, T.; Servitova, L.; Jost, K.
Post-proline endopeptidase. Further characterization of the enzyme from pig kidneys
Collect. Czech. Chem. Commun.
49
1846-1853
1984
Sus scrofa
-
Manually annotated by BRENDA team
Daly, D.J.; Maskrey, P.; Mantle, D.; Pennington, R.J.T.
Proline endopeptidase in human muscle
Biochem. Soc. Trans.
13
1161-1163
1985
Homo sapiens
-
Manually annotated by BRENDA team
Bocskei, Z.; Fuxreiter, M.; Naray-Szabo, G.; Szabo, E.; Polar, L.
Crystallization and preliminary X-ray analysis of porcine muscle prolyl oligopeptidase
Acta Crystallogr. Sect. D
54
1414-1415
1998
Sus scrofa
Manually annotated by BRENDA team
Knisatschek, H.; Bauer, K.
Specific inhibition of post proline cleaving enzyme by benzyloxycarbonyl-Gly-Pro-diazomethyl ketone
Biochem. Biophys. Res. Commun.
134
888-894
1986
Bos taurus
Manually annotated by BRENDA team
Nomura, K.
Specificity of prolyl endopeptidase
FEBS Lett.
209
235-237
1986
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Hauzer, K.; Barth, T.; Jost, K.; Barthova, J.; Hauzerova, L.
Endoprolylpeptidase (EC 3.4.21.26), improvement of the isolation method
Collect. Czech. Chem. Commun.
52
522-524
1987
Sus scrofa
-
Manually annotated by BRENDA team
Momand, J.; Clarke, S.
Rapid degradation of D- and L-succinimide-containing peptides by a post-proline endopeptidase from human erythrocytes
Biochemistry
26
7798-7805
1987
Homo sapiens
Manually annotated by BRENDA team
Yoshimoto, T.; Abdus Sattar, A.K.M.; Hirose, W.; Tsuru, D.
Studies on prolyl endopeptidase from carrot (Daucus carota): purification and enzymatic properties
Biochim. Biophys. Acta
916
29-37
1987
Daucus carota
-
Manually annotated by BRENDA team
Tsuru, D.; Yoshimoto, T.; Koriyama, N.; Furukawa, S.
Thiazolidine derivatives as potent inhibitors specific for prolyl endopeptidase
J. Biochem.
104
580-586
1988
Bos taurus
Manually annotated by BRENDA team
Ohtsuki, S.; Homma, K.I.; Kurata, S.; Natori, S.
Molecular cloning of cDNA for Sarcophaga prolyl endopeptidase and characterization of the recombinant enzyme produced by an E. coli expression system
Insect Biochem. Mol. Biol.
27
337-343
1997
Sarcophaga peregrina
Manually annotated by BRENDA team
Yokosawa, H.; Nishikata, M.; Ishii, S.
Involvement of prolyl endopeptidase in ascidian fertilization
Experientia
45
381-383
1989
Halocynthia roretzi
Manually annotated by BRENDA team
Moriyama, A.; Nakanishi, M.; Takenaka, O.; Sasaki, M.
Porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds
Biochim. Biophys. Acta
956
151-155
1988
Sus scrofa
Manually annotated by BRENDA team
Kuwabara, T.
Characterization of a prolyl endopeptidase from spinach thylakoids
FEBS Lett.
300
127-130
1992
Spinacia oleracea
Manually annotated by BRENDA team
Harwood, V.J.; Denson, J.D.; Robinson-Bidle, K.A.; Schreier, H.J.
Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus
J. Bacteriol.
179
3613-3618
1997
Pyrococcus furiosus
Manually annotated by BRENDA team
Goossens, F.; De Meester, I.; Vanhoof, G.; Hendriks, D.; Vriend, G.; Scharpe, S.
The purification, characterization and analysis of primary and secondary-structure of prolyl oligopeptidase from human lymphocytes. Evidence that the enzyme belongs to the alpha/beta hydrolase fold family
Eur. J. Biochem.
233
432-441
1995
Homo sapiens
Manually annotated by BRENDA team
Quemeneur, E.; Moutiez, M.; Charbonnier, J.B.; Menez, A.
Engineering cyclophilin into a proline-specific endopeptidase [published erratum appears in Nature 1998 Jul 16;394(6690):302
Nature
391
301-303
1998
Escherichia coli
Manually annotated by BRENDA team
Chevallier, S.; Goeltz, P.; Thibault, P.; Banville, D.; Gagnon, J.
Characterization of a prolyl endopeptidase from Flavobacterium meningosepticum. Complete sequence and localization of the active-site serine
J. Biol. Chem.
267
8192-8199
1992
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Oyama, H.; Aoki, H.; Amano, M.; Mizuki, E.; Yoshimoto, T.; Tsuru, D.; Murao, S.
Purification and characterization of a prolyl endopeptidase from Pseudomonas sp. KU-22
J. Ferment. Bioeng.
84
538-542
1997
Pseudomonas sp., Pseudomonas sp. KU-22
-
Manually annotated by BRENDA team
Sharma, K.K.; Ortwerth, B.J.
Purification and characterization of prolyl oligopeptidase from bovine lens
Exp. Eye Res.
59
107-116
1994
Bos taurus
Manually annotated by BRENDA team
Strohmeier, U.; Gerdes, C.; Lockau, W.
Proteolysis in heterocyst-forming cyanobacteria: Characterization of a further enzyme with trypsin-like specificity, and of prolyl endopeptidase from Anabaena variabilis
Z. Naturforsch. C
49
70-78
1994
Trichormus variabilis, Trichormus variabilis ATC29413
Manually annotated by BRENDA team
Nozaki, Y.; Sato, N.; Iida, T.; Hara, K.; Fukuyama, K.; Epstein, W.L.
Prolyl endopeptidase purified from granulomatous inflammation in mice
J. Cell. Biochem.
49
296-303
1992
Mus musculus
Manually annotated by BRENDA team
Shirasawa, Y.; Osawa, T.; Hirashima, A.
Molecular cloning and characterization of prolyl endopeptidase from human T cells
J. Biochem.
115
724-729
1994
Homo sapiens
Manually annotated by BRENDA team
Kanatani, A.; Yoshimoto, T.; Kitazono, A.; Kokubo, T.; Tsuru, D.
Prolyl endopeptidase from Aeromonas hydrophila: cloning, sequencing, and expression of the enzyme gene, and characterization of the expressed enzyme
J. Biochem.
113
790-796
1993
Aeromonas hydrophila
Manually annotated by BRENDA team
Sattar, A.K.M.A.; Yamamoto N.; Yoshimoto, T.; Tsuru, D.
Purification and characterization of an extracellular prolyl endopeptidase from Agaricus bisporus
J. Biochem.
107
256-261
1990
Agaricus bisporus
Manually annotated by BRENDA team
Kabashima, T.; Fujii, M.; Meng, Y.; Ito, K.; Yoshimoto, T.
Prolyl endopeptidase from Sphingomonas capsulata: isolation and characterization of the enzyme and nucleotide sequence of the gene
Arch. Biochem. Biophys.
358
141-148
1998
Novosphingobium capsulatum (Q9ZNM8), Novosphingobium capsulatum
Manually annotated by BRENDA team
Schoenlein, C.; Heins, J.; Barth, A.
Purification and characterization of prolyl endopeptidase from pig brain
Biol. Chem.
371
1159-1164
1990
Sus scrofa
Manually annotated by BRENDA team
Chen, Y.S.; Christensen, J.E.; Broadbent, J.R.; Steele, J.L.
Identification and characterization of Lactobacillus helveticus PepO2, an endopeptidase with post-proline specificity
Appl. Environ. Microbiol.
69
1276-1282
2003
Lactobacillus helveticus (Q8VTS9), Lactobacillus helveticus, Lactobacillus helveticus CNRZ32 (Q8VTS9), Lactobacillus helveticus CNRZ32
Manually annotated by BRENDA team
Kim, J.H.; Kim, S.I.; Song, K.S.
Prolyl endopeptidase inhibitors from green tea
Arch. Pharm. Res.
24
292-296
2001
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Kobayashi, W.; Miyase, T.; Sano, M.; Umehara, K.; Warashina, T.; Noguchi, H.
Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill
Biol. Pharm. Bull.
25
1049-1052
2002
Elizabethkingia meningoseptica, Rattus norvegicus
Manually annotated by BRENDA team
Wallen, E.A.; Christiaans, J.A.; Saario, S.M.; Forsberg, M.M.; Venalainen, J.I.; Paso, H.M.; Mannisto, P.T.; Gynther, J.
4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors
Bioorg. Med. Chem.
10
2199-2206
2002
Sus scrofa
Manually annotated by BRENDA team
Wallen, E.A.; Christiaans, J.A.; Saarinen, T.J.; Jarho, E.M.; Forsberg, M.M.; Venalainen, J.I.; Mannisto, P.T.; Gynther, J.
Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors
Bioorg. Med. Chem.
11
3611-3619
2003
Sus scrofa
Manually annotated by BRENDA team
Fan, W.; Tezuka, Y.; Kadota, S.
Prolyl endopeptidase inhibitory activity of fourteen Kampo formulas and inhibitory constituents of Tokaku-joki-to
Chem. Pharm. Bull.
48
1055-1061
2000
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Fan, W.; Tezuka, Y.; Ni, K.M.; Kadota, S.
Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis
Chem. Pharm. Bull.
49
396-401
2001
Flavobacterium sp.
Manually annotated by BRENDA team
Quinto, B.M.; Juliano, M.A.; Hirata, I.; Carmona, A.K.; Juliano, L.; Casarini, D.E.
Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates
Int. J. Biochem. Cell Biol.
32
1161-1172
2000
Homo sapiens
Manually annotated by BRENDA team
Flp, V.; Szeltner, Z.; Renner, V.; Polgar, L.
Structures of prolyl oligopeptidase substrate/inhibitor complexes. Use of inhibitor binding for titration of the catalytic histidine residue
J. Biol. Chem.
276
1262-1266
2001
Sus scrofa (P23687)
Manually annotated by BRENDA team
Szeltner, Z.; Rea, D.; Renner, V.; Fulop, V.; Polgar, L.
Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site
J. Biol. Chem.
277
42613-42622
2002
Sus scrofa (P23687)
Manually annotated by BRENDA team
Szeltner, Z.; Rea, D.; Juhasz, T.; Renner, V.; Mucsi, Z.; Orosz, G.; Fulop, V.; Polgar, L.
Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase
J. Biol. Chem.
277
44597-44605
2002
Sus scrofa (P23687)
Manually annotated by BRENDA team
Szeltner, Z.; Rea, D.; Renner, V.; Juliano, L.; Fulop, V.; Polgar, L.
Electrostatic environment at the active site of prolyl oligopeptidase is highly influential during substrate binding
J. Biol. Chem.
278
48786-48793
2003
Sus scrofa (P23687)
Manually annotated by BRENDA team
Wallen, E.A.; Christiaans, J.A.; Forsberg, M.M.; Venalainen, J.I.; Mannisto, P.T.; Gynther, J.
Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors
J. Med. Chem.
45
4581-4584
2002
Sus scrofa
Manually annotated by BRENDA team
Wallen, E.A.; Christiaans, J.A.; Jarho, E.M.; Forsberg, M.M.; Venalainen, J.I.; Mannisto, P.T.; Gynther, J.
New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides
J. Med. Chem.
46
4543-4551
2003
Pyrococcus furiosus, Sus scrofa
Manually annotated by BRENDA team
Fruitier-Arnaudin, I.; Cohen, M.; Coitoux, C.; Piot, J.M.
In vitro metabolism of LVV-Hemorphin-7 by renal cytosol and purified prolyl endopeptidase
Peptides
24
1201-1206
2003
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Irazusta, J.; Silveira, P.F.; Gil, J.; Varona, A.; Casis, L.
Effects of hydrosaline treatments on prolyl endopeptidase activity in rat tissues
Regul. Pept.
101
141-147
2001
Rattus norvegicus
Manually annotated by BRENDA team
Besedin, D.V.; Rudenskaya, G.N.
Proline-specific endopeptidases
Russ. J. Bioorg. Chem.
29
1-17
2003
Agaricus bisporus, Bos taurus, Cavia porcellus, Gallus gallus, Elizabethkingia meningoseptica, Oryctolagus cuniculus, Novosphingobium capsulatum, Ovis aries, Homo sapiens, Lyophyllum cinerascens, Mus musculus, Rattus norvegicus, Sus scrofa, Xanthomonas sp., Ascidia sp., Clupea pallasii, Lactifluus hygrophoroides, Russula lepida
-
Manually annotated by BRENDA team
Venaelaeinen, J.I.; Juvonen, R.O.; Garcia-Horsman, J.A.; Wallen, E.A.; Christiaans, J.A.; Jarho, E.M.; Gynther, J.; Maennistoe, P.T.
Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site
Biochem. J.
382
1003-1008
2004
Sus scrofa
Manually annotated by BRENDA team
Bastos, I.M.; Grellier, P.; Martins, N.F.; Cadavid-Restrepo, G.; de Souza-Ault, M.R.; Augustyns, K.; Teixeira, A.R.; Schrevel, J.; Maigret, B.; da Silveira, J.F.; Santana, J.M.
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells
Biochem. J.
388
29-38
2005
Trypanosoma cruzi (Q71MD6), Trypanosoma cruzi
Manually annotated by BRENDA team
Olivo, R.d.o.A.; Teixeira, C.d.e.F.; Silveira, P.F.
Representative aminopeptidases and prolyl endopeptidase from murine macrophages: comparative activity levels in resident and elicited cells
Biochem. Pharmacol.
69
1441-1450
2005
Mus musculus
Manually annotated by BRENDA team
Venaelaeinen, J.I.; Garcia-Horsman, J.A.; Forsberg, M.M.; Jalkanen, A.; Wallen, E.A.; Jarho, E.M.; Christiaans, J.A.; Gynther, J.; Maennistoe, P.T.
Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors
Biochem. Pharmacol.
71
683-692
2006
Sus scrofa
Manually annotated by BRENDA team
Heinis, C.; Alessi, P.; Neri, D.
Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy
Biochemistry
43
6293-6303
2004
Homo sapiens
Manually annotated by BRENDA team
Diderot, N.T.; Silvere, N.; Yasin, A.; Zareen, S.; Fabien, Z.; Etienne, T.; Choudhary, M.I.; Atta-Ur-Rahman, M.I.
Prolyl endopeptidase and thrombin inhibitory diterpenoids from the bark of Xylopia aethiopica
Biosci. Biotechnol. Biochem.
69
1763-1766
2005
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Szeltner, Z.; Alshafee, I.; Juhasz, T.; Parvari, R.; Polgar, L.
The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity
Cell. Mol. Life Sci.
62
2376-2381
2005
Homo sapiens (Q4J6C6)
Manually annotated by BRENDA team
Juhasz, T.; Szeltner, Z.; Polgar, L.
Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus
FEBS Lett.
580
3493-3497
2006
Pyrococcus furiosus
Manually annotated by BRENDA team
Matysiak-Budnik, T.; Candalh, C.; Cellier, C.; Dugave, C.; Namane, A.; Vidal-Martinez, T.; Cerf-Bensussan, N.; Heyman, M.
Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease
Gastroenterology
129
786-796
2005
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Park, Y.S.; Jang, H.J.; Lee, K.H.; Hahn, T.R.; Paik, Y.S.
Prolyl endopeptidase inhibitory activity of unsaturated fatty acids
J. Agric. Food Chem.
54
1238-1242
2006
Homo sapiens
Manually annotated by BRENDA team
Jarho, E.M.; Wallen, E.A.; Christiaans, J.A.; Forsberg, M.M.; Venaelaeinen, J.I.; Maennistoe, P.T.; Gynther, J.; Poso, A.
Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions
J. Med. Chem.
48
4772-4782
2005
Sus scrofa (P23687), Sus scrofa
Manually annotated by BRENDA team
Juhasz, T.; Szeltner, Z.; Fueloep, V.; Polgar, L.
Unclosed beta-propellers display stable structures: implications for substrate access to the active site of prolyl oligopeptidase
J. Mol. Biol.
346
907-917
2005
Sus scrofa (P23687)
Manually annotated by BRENDA team
Schulz, I.; Zeitschel, U.; Rudolph, T.; Ruiz-Carrillo, D.; Rahfeld, J.U.; Gerhartz, B.; Bigl, V.; Demuth, H.U.; Rossner, S.
Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion
J. Neurochem.
94
970-979
2005
Homo sapiens
Manually annotated by BRENDA team
Piper, J.L.; Gray, G.M.; Khosla, C.
Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo
J. Pharmacol. Exp. Ther.
311
213-219
2004
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Marti, T.; Molberg, O.; Li, Q.; Gray, G.M.; Khosla, C.; Sollid, L.M.
Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization
J. Pharmacol. Exp. Ther.
312
19-26
2005
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Lee, J.H.; Lee, S.Y.; Lee, K.S.; Jang, H.J.; Lee, K.H.; Hahn, T.R.; Paik, Y.S.
Prolyl endopeptidase inhibitors from the leaves of Ginkgo biloba
Planta Med.
70
1228-1230
2004
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Amor, E.C.; Villasenor, I.M.; Yasin, A.; Choudhary, M.I.
Prolyl endopeptidase inhibitors from Syzygium samarangense (Blume) Merr. & L. M. Perry
Z. Naturforsch. C
59
86-92
2004
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Stepniak, D.; Spaenij-Dekking, L.; Mitea, C.; Moester, M.; de Ru, A.; Baak-Pablo, R.; van Veelen, P.; Edens, L.; Koning, F.
Highly efficient gluten degradation with a newly identified: implications for celiac disease
Am. J. Physiol. Gastrointest. Liver Physiol.
291
G621-G629
2006
Aspergillus niger
Manually annotated by BRENDA team
Lee, S.H.; Jun, M.; Choi, J.Y.; Yang, E.J.; Hur, J.M.; Bae, K.; Seong, Y.H.; Huh, T.L.; Song, K.S.
Plant phenolics as prolyl endopeptidase inhibitors
Arch. Pharm. Res.
30
827-833
2007
Homo sapiens
Manually annotated by BRENDA team
Jarho, E.M.; Venaelaeinen, J.I.; Poutiainen, S.; Leskinen, H.; Vepsaelaeinen, J.; Christiaans, J.A.; Forsberg, M.M.; Maennistoe, P.T.; Wallen, E.A.
2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors
Bioorg. Med. Chem.
15
2024-2031
2007
Sus scrofa
Manually annotated by BRENDA team
Krupina, N.A.; Zolotov, N.N.; Bogdanova, N.G.; Orlova, I.N.; Khlebnikova, N.N.; Kryzhanovskii, G.N.
Activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats with dopamine deficiency-dependent MPTP-induced depressive syndrome
Bull. Exp. Biol. Med.
142
554-556
2006
Rattus norvegicus
Manually annotated by BRENDA team
Rea, D.; Fueloep, V.
Structure-function properties of prolyl oligopeptidase family enzymes
Cell Biochem. Biophys.
44
349-365
2006
Homo sapiens, Myxococcus xanthus, Pyrococcus furiosus, Trypanosoma cruzi, Novosphingobium capsulatum (Q9ZNM8)
Manually annotated by BRENDA team
Gass, J.; Khosla, C.
Prolyl endopeptidases
Cell. Mol. Life Sci.
64
345-355
2007
Elizabethkingia meningoseptica, Dictyostelium discoideum, Novosphingobium capsulatum, Homo sapiens, Mus musculus, Myxococcus xanthus, Pyrococcus furiosus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Brandt, I.; Scharpe, S.; Lambeir, A.M.
Suggested functions for prolyl oligopeptidase: a puzzling paradox
Clin. Chim. Acta
377
50-61
2007
Elizabethkingia meningoseptica, Homo sapiens, Mus musculus, Rattus norvegicus, Trypanosoma cruzi
Manually annotated by BRENDA team
Olivo, R.A.; Nascimento, N.G.; Teixeira, C.F.; Silveira, P.F.
Methotrexate and cyclosporine treatments modify the activities of dipeptidyl peptidase IV and prolyl oligopeptidase in murine macrophages
Clin. Dev. Immunol.
2008
794050
2008
Mus musculus
Manually annotated by BRENDA team
Szeltner, Z.; Polgar, L.
Structure, function and biological relevance of prolyl oligopeptidase
Curr. Protein Pept. Sci.
9
96-107
2008
Dictyostelium discoideum, Elizabethkingia meningoseptica, Homo sapiens, Mus musculus, Myxococcus xanthus, Novosphingobium capsulatum, Platyrrhini, Pyrococcus furiosus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Mitea, C.; Havenaar, R.; Drijfhout, J.W.; Edens, L.; Dekking, L.; Koning, F.
Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease
Gut
57
25-32
2008
Aspergillus niger
Manually annotated by BRENDA team
Je, J.Y.; Kim, E.K.; Ahn, C.B.; Moon, S.H.; Jeon, B.T.; Kim, B.; Park, T.K.; Park, P.J.
Sulfated chitooligosaccharides as prolyl endopeptidase inhibitor
Int. J. Biol. Macromol.
41
529-533
2007
Elizabethkingia meningoseptica
Manually annotated by BRENDA team
Lee, H.S.; Kim, Y.J.; Cho, Y.; Kim, S.J.; Lee, J.H.; Kang, S.G.
Characterization of prolyl oligopeptidase from hyperthermophilic archaeon Thermococcus sp. NA1
J. Biosci. Bioeng.
103
221-228
2007
Thermococcus onnurineus (Q2QC90)
Manually annotated by BRENDA team
Myoehaenen, T.T.; Venaelaeinen, J.I.; Garcia-Horsman, J.A.; Piltonen, M.; Maennistoe, P.T.
Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters
J. Comp. Neurol.
507
1694-1708
2008
Rattus norvegicus
Manually annotated by BRENDA team
Myoehaenen, T.T.; Venaelaeinen, J.I.; Tupala, E.; Garcia-Horsman, J.A.; Miettinen, R.; Maennistoe, P.T.
Distribution of immunoreactive prolyl oligopeptidase in human and rat brain
Neurochem. Res.
32
1365-1374
2007
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Garcia-Horsman, J.A.; Maennistoe, P.T.; Venaelaeinen, J.I.
On the role of prolyl oligopeptidase in health and disease
Neuropeptides
41
1-24
2007
Dictyostelium discoideum, Novosphingobium capsulatum, Flavobacterium sp., Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa (P23687)
Manually annotated by BRENDA team
Leprince, J.; Cosquer, D.; Bellemere, G.; Chatenet, D.; Tollemer, H.; Jegou, S.; Tonon, M.; Vaudry, H.
Catabolism of the octadecaneuropeptide ODN by prolyl endopeptidase: identification of an unusual cleavage site
Peptides
27
1561-1569
2006
Flavobacterium sp.
Manually annotated by BRENDA team
Gorrao, S.S.; Hemerly, J.P.; Lima, A.R.; Melo, R.L.; Szeltner, Z.; Polgar, L.; Juliano, M.A.; Juliano, L.
Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase
Peptides
28
2146-2154
2007
Sus scrofa
Manually annotated by BRENDA team
Juhasz, T.; Szeltner, Z.; Polgar, L.
Truncated prolyl oligopeptidase from Pyrococcus furiosus
Proteins
69
633-643
2007
Pyrococcus furiosus, Sus scrofa (P23687)
Manually annotated by BRENDA team
Haffner, C.D.; Diaz, C.J.; Miller, A.B.; Reid, R.A.; Madauss, K.P.; Hassell, A.; Hanlon, M.H.; Porter, D.J.; Becherer, J.D.; Carter, L.H.
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
Bioorg. Med. Chem. Lett.
18
4360-4363
2008
Homo sapiens
Manually annotated by BRENDA team
Tarrago, T.; Masdeu, C.; Gomez, E.; Isambert, N.; Lavilla, R.; Giralt, E.
Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors
ChemMedChem
3
1558-1565
2008
Homo sapiens
Manually annotated by BRENDA team
Tenorio-Laranga, J.; Venaelaeinen, J.I.; Maennistoe, P.T.; Garcia-Horsman, J.A.
Characterization of membrane-bound prolyl endopeptidase from brain
FEBS J.
275
4415-4427
2008
Sus scrofa
Manually annotated by BRENDA team
Klegeris, A.; Li, J.; Bammler, T.K.; Jin, J.; Zhu, D.; Kashima, D.T.; Pan, S.; Hashioka, S.; Maguire, J.; McGeer, P.L.; Zhang, J.
Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity
Glia
56
675-685
2008
Homo sapiens (P48147)
Manually annotated by BRENDA team
Myoehaenen, T.T.; Venaelaeinen, J.I.; Garcia-Horsman, J.A.; Piltonen, M.; Maennistoe, P.T.
Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues
Histochem. Cell Biol.
130
993-1003
2008
Mus musculus
Manually annotated by BRENDA team
Van Gool, A.R.; Verkerk, R.; Fekkes, D.; Sleijfer, S.; Bannink, M.; Kruit, W.H.; van der Holt, B.; Scharpe, S.; Eggermont, A.M.; Stoter, G.; Hengeveld, M.W.
Plasma activity of prolyl endopeptidase in relation to psychopathology during immunotherapy with IFN-alpha in patients with renal cell carcinoma
J. Interferon Cytokine Res.
28
283-286
2008
Homo sapiens
Manually annotated by BRENDA team
Kanai, K.; Aranyi, P.; Boecskei, Z.; Ferenczy, G.; Harmat, V.; Simon, K.; Batori, S.; Naray-Szabo, G.; Hermecz, I.
Prolyl oligopeptidase inhibition by N-acyl-pro-pyrrolidine-type molecules
J. Med. Chem.
51
7514-7522
2008
Sus scrofa (P23687)
Manually annotated by BRENDA team
Di Daniel, E.; Glover, C.P.; Grot, E.; Chan, M.K.; Sanderson, T.H.; White, J.H.; Ellis, C.L.; Gallagher, K.T.; Uney, J.; Thomas, J.; Maycox, P.R.; Mudge, A.W.
Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity
Mol. Cell. Neurosci.
41
373-382
2009
Rattus norvegicus (O70196)
Manually annotated by BRENDA team
Myoehaenen, T.T.; Kaeaeriaeinen, T.M.; Jalkanen, A.J.; Piltonen, M.; Maennistoe, P.T.
Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain
Neurosci. Lett.
450
201-205
2009
Rattus norvegicus
Manually annotated by BRENDA team
Myoehaenen, T.T.; Venaelaeinen, J.I.; Garcia-Horsman, J.A.; Maennistoe, P.T.
Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study
Neuroscience
153
1177-1189
2008
Rattus norvegicus
Manually annotated by BRENDA team
Moreno-Baylach, M.J.; Felipo, V.; Maennistoe, P.T.; Garcia-Horsman, J.A.
Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging
Neuroscience
156
580-585
2008
Homo sapiens
Manually annotated by BRENDA team
Brandt, I.; Gerard, M.; Sergeant, K.; Devreese, B.; Baekelandt, V.; Augustyns, K.; Scharpe, S.; Engelborghs, Y.; Lambeir, A.M.
Prolyl oligopeptidase stimulates the aggregation of alpha-synuclein
Peptides
29
1472-1478
2008
Sus scrofa
Manually annotated by BRENDA team
Gutierrez, L.; Castelain, M.; Verdeil, J.L.; Conejero, G.; Van Wuytswinkel, O.
A possible role of prolyl oligopeptidase during Linum usitatissimum (flax) seed development
Plant Biol.
10
398-402
2008
Arabidopsis thaliana, Linum usitatissimum
Manually annotated by BRENDA team
Ehren, J.; Govindarajan, S.; Moron, B.; Minshull, J.; Khosla, C.
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy
Protein Eng. Des. Sel.
21
699-707
2008
Novosphingobium capsulatum (Q9ZNM8)
Manually annotated by BRENDA team
Cornell, H.J.; Doherty, W.; Stelmasiak, T.
Papaya latex enzymes capable of detoxification of gliadin
Amino Acids
38
155-165
2009
Carica papaya
Manually annotated by BRENDA team
Tenorio-Laranga, J.; Valero, M.L.; Maennistoe, P.T.; Sanchez del Pino, M.; Garcia-Horsman, J.A.
Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain
Anal. Biochem.
393
80-87
2009
Rattus norvegicus
Manually annotated by BRENDA team
Peltonen, I.; Jalkanen, A.J.; Sinervae, V.; Puttonen, K.A.; Maennistoe, P.T.
Different effects of scopolamine and inhibition of prolyl oligopeptidase on mnemonic and motility functions of young and 8- to 9-month-old rats in the radial-arm maze
Basic Clin. Pharmacol. Toxicol.
106
280-287
2010
Rattus norvegicus
Manually annotated by BRENDA team
Nolte, W.M.; Tagore, D.M.; Lane, W.S.; Saghatelian, A.
Peptidomics of prolyl endopeptidase in the central nervous system
Biochemistry
48
11971-11981
2009
Mus musculus
Manually annotated by BRENDA team
Khlebnikova, N.N.; Krupina, N.A.; Bogdanova, N.G.; Zolotov, N.N.; Kryzhanovskii, G.N.
Effects of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on experimental depressive syndrome development in rats
Bull. Exp. Biol. Med.
147
26-30
2009
Rattus norvegicus
Manually annotated by BRENDA team
Khlebnikova, N.N.; Krupina, N.A.; Orlova, I.N.; Bogdanova, N.G.; Zolotov, N.N.; Kryzhanovskii, G.N.
Effect of a prolyl endopeptidase inhibitor benzyloxycarbonyl-alanyl-proline on the development of experimental depressive syndrome in rats
Bull. Exp. Biol. Med.
147
291-295
2009
Rattus norvegicus
Manually annotated by BRENDA team
Tarrag, T.; Claasen, B.; Kichik, N.; Rodriguez-Mias, R.; Gair, M.; Giralt, E.
A cost-effective labeling strategy for the NMR study of large proteins: Selective 15N-labeling of the tryptophan side chains of prolyl oligopeptidase
ChemBioChem
10
2736-2739
2009
Sus scrofa
Manually annotated by BRENDA team
Deutch, C.; Krumbholz, R.; Schmid, S.; Bonate, P.; Jurutka, P.
Conversion of the anti-tumor agent tasidotin (ILX651) to its active metabolite by prolyl oligopeptidase
Enzyme Microb. Technol.
46
246-251
2010
Elizabethkingia meningoseptica
-
Manually annotated by BRENDA team
Tarrago, T.; Martin-Benito, J.; Sabido, E.; Claasen, B.; Madurga, S.; Gairi, M.; Valpuesta, J.M.; Giralt, E.
A new side opening on prolyl oligopeptidase revealed by electron microscopy
FEBS Lett.
583
3344-3348
2009
Homo sapiens
Manually annotated by BRENDA team
Marques, M.R.; Stueker, C.; Kichik, N.; Tarrago, T.; Giralt, E.; Morel, A.F.; Dalcol, I.I.
Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers
Fitoterapia
81
552-6
2010
Homo sapiens
Manually annotated by BRENDA team
Park, D.H.; Park, S.J.; Kim, J.M.; Jung, W.Y.; Ryu, J.H.
Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances
Fitoterapia
81
644-8
2010
Mus musculus
Manually annotated by BRENDA team
Warden, C.H.; Fisler, J.S.; Espinal, G.; Graham, J.; Havel, P.J.; Perroud, B.
Maternal influence of prolyl endopeptidase on fat mass of adult progeny
Int. J. Obes.
33
1013-1022
2009
Mus musculus
Manually annotated by BRENDA team
Luo, H.; Hallen-Adams, H.E.; Walton, J.D.
Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes
J. Biol. Chem.
284
18070-18077
2009
Conocybe apala (C4P9M4), Conocybe apala
Manually annotated by BRENDA team
Li, M.; Chen, C.; Davies, D.R.; Chiu, T.K.
An induced-fit mechanism for prolyl endopeptidase
J. Biol. Chem.
285
21487-95
2010
Aeromonas caviae (Q9X6R4)
Manually annotated by BRENDA team
Agirregoitia, N.; Bizet, P.; Agirregoitia, E.; Boutelet, I.; Peralta, L.; Vaudry, H.; Jegou, S.
Prolyl endopeptidase mRNA expression in the central nervous system during rat development
J. Chem. Neuroanat.
40
53-62
2010
Rattus norvegicus (O70196)
Manually annotated by BRENDA team
Sebela, M.; Rehulka, P.; Kabrt, J.; Rehulkova, H.; Ozdian, T.; Raus, M.; Franc, V.; Chmelik, J.
Identification of N-glycosylation in prolyl endoprotease from Aspergillus niger and evaluation of the enzyme for its possible application in proteomics
J. Mass Spectrom.
44
1587-1595
2009
Aspergillus niger (A2QR21), Aspergillus niger
Manually annotated by BRENDA team
Lawandi, J.; Toumieux, S.; Seyer, V.; Campbell, P.; Thielges, S.; Juillerat-Jeanneret, L.; Moitessier, N.
Constrained peptidomimetics reveal detailed geometric requirements of covalent prolyl oligopeptidase inhibitors
J. Med. Chem.
52
6672-6684
2009
Homo sapiens
Manually annotated by BRENDA team
Lawandi, J.; Gerber-Lemaire, S.; Juillerat-Jeanneret, L.; Moitessier, N.
Inhibitors of prolyl oligopeptidases for the therapy of human diseases: Defining diseases and inhibitors
J. Med. Chem.
53
3423-3438
2010
Bos taurus, Canis lupus familiaris, Elizabethkingia meningoseptica, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa (P23687)
Manually annotated by BRENDA team
OReilly, P.J.; Hardison, M.T.; Jackson, P.L.; Xu, X.; Snelgrove, R.J.; Gaggar, A.; Galin, F.S.; Blalock, J.E.
Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen
J. Neuroimmunol.
217
51-54
2009
Homo sapiens
Manually annotated by BRENDA team
Tenorio-Laranga, J.; Coret-Ferrer, F.; Casanova-Estruch, B.; Burgal, M.; Garcia-Horsman, J.A.
Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis
J. Neuroinflammation
7
23
2010
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Bastos, I.M.; Motta, F.N.; Charneau, S.; Santana, J.M.; Dubost, L.; Augustyns, K.; Grellier, P.
Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice
Microbes Infect.
12
457-66
2010
Trypanosoma brucei brucei (Q6HA27)
Manually annotated by BRENDA team
Perroud, B.; Alvarado, R.; Espinal, G.; Morado, A.; Phinney, B.; Warden, C.
In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice
Mol. Brain
2
14
2009
Mus musculus
Manually annotated by BRENDA team
Comellas, G.; Kaczmarska, Z.; Tarrag, T.; Teixid, M.; Giralt, E.
Exploration of the one-bead one-compound methodology for the design of prolyl oligopeptidase substrates
PLoS ONE
4
e6222
2009
Sus scrofa
Manually annotated by BRENDA team
Larrinaga, G.; Perez, I.; Blanco, L.; Lopez, J.I.; Andres, L.; Etxezarraga, C.; Santaolalla, F.; Zabala, A.; Varona, A.; Irazusta, J.
Increased prolyl endopeptidase activity in human neoplasia
Regul. Pept.
163
102-106
2010
Homo sapiens
Manually annotated by BRENDA team
Braber, S.; Koelink, P.J.; Henricks, P.A.; Jackson, P.L.; Nijkamp, F.P.; Garssen, J.; Kraneveld, A.D.; Blalock, J.E.; Folkerts, G.
Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown
Am. J. Physiol. Lung Cell Mol. Physiol.
300
L255-L265
2011
Mus musculus
Manually annotated by BRENDA team
Darkoh, C.; El-Bouhssini, M.; Baum, M.; Clack, B.
Characterization of a prolyl endoprotease from Eurygaster integriceps Puton (Sunn pest) infested wheat
Arch. Insect Biochem. Physiol.
74
163-178
2010
Eurygaster integriceps
Manually annotated by BRENDA team
Peltonen, I.; Maennistoe, P.T.
Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase
Basic Clin. Pharmacol. Toxicol.
108
46-54
2011
Rattus norvegicus
Manually annotated by BRENDA team
Sakaguchi, M.; Matsuda, T.; Matsumura, E.; Yoshimoto, T.; Takaoka, M.
Prolyl oligopeptidase participates in cell cycle progression in a human neuroblastoma cell line
Biochem. Biophys. Res. Commun.
409
693-698
2011
Homo sapiens
Manually annotated by BRENDA team
Myoehaenen, T.T.; Tenorio-Laranga, J.; Jokinen, B.; Vazquez-Sanchez, R.; Moreno-Baylach, M.J.; Garcia-Horsman, J.A.; Maennistoe, P.T.
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner
Br. J. Pharmacol.
163
1666-1678
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Hannula, M.J.; Maennistoe, P.T.; Myoehaenen, T.T.
Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain
Dev. Neurosci.
33
38-47
2011
Rattus norvegicus
Manually annotated by BRENDA team
Luo, H.; Hallen-Adams, H.E.; Scott-Craig, J.S.; Walton, J.D.
Colocalization of amanitin and a candidate toxin-processing prolyl oligopeptidase in Amanita basidiocarps
Eukaryot. Cell
9
1891-1900
2010
Amanita bisporigera (E2JFG1), Amanita bisporigera (E2JFG2)
Manually annotated by BRENDA team
Huang, C.H.; Suen, C.S.; Lin, C.T.; Chien, C.H.; Lee, H.Y.; Chung, K.M.; Tsai, T.Y.; Jiaang, W.T.; Hwang, M.J.; Chen, X.
Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate
J. Biochem.
149
685-692
2011
Homo sapiens
Manually annotated by BRENDA team
Matsubara, S.; Takahashi, T.; Kimura, A.P.
Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta
J. Mol. Histol.
42
251-264
2011
Mus musculus
Manually annotated by BRENDA team
Klimaviciusa, L.; Jain, R.K.; Jaako, K.; Van Elzen, R.; Gerard, M.; van Der Veken, P.; Lambeir, A.M.; Zharkovsky, A.
In situ prolyl oligopeptidase activity assay in neural cell cultures
J. Neurosci. Methods
204
104-110
2012
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Moreno-Baylach, M.J.; Puttonen, K.A.; Tenorio-Laranga, J.; Venaelaeinen, J.I.; Storvik, M.; Forsberg, M.M.; Garcia-Horsman, J.A.
Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells
Neurosignals
19
97-109
2011
Homo sapiens
Manually annotated by BRENDA team
Harris, M.N.; Madura, J.D.; Ming, L.J.; Harwood, V.J.
Kinetic and mechanistic studies of prolyl oligopeptidase from the hyperthermophile Pyrococcus furiosus
J. Biol. Chem.
276
19310-19317
2001
Pyrococcus furiosus
Manually annotated by BRENDA team
Alvarez-Sieiro, P.; Martin, M.C.; Redruello, B.; Del Rio, B.; Ladero, V.; Palanski, B.A.; Khosla, C.; Fernandez, M.; Alvarez, M.A.
Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase
Appl. Microbiol. Biotechnol.
98
6689-6700
2014
Myxococcus xanthus
Manually annotated by BRENDA team
Szeltner, Z.; Juhasz, T.; Szamosi, I.; Rea, D.; Fueloep, V.; Modos, K.; Juliano, L.; Polgar, L.
The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity
Biochim. Biophys. Acta
1834
98-111
2013
Homo sapiens
Manually annotated by BRENDA team
Kaszuba, K.; Rog, T.; Danne, R.; Canning, P.; Fueloep, V.; Juhasz, T.; Szeltner, Z.; St Pierre, J.F.; Garcia-Horsman, A.; Maennistoe, P.T.; Karttunen, M.; Hokkanen, J.; Bunker, A.
Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase
Biochimie
94
1398-1411
2012
Sus scrofa (P23687)
Manually annotated by BRENDA team
Rentzsch, A.; Kahlert, V.; Jahreis, G.; Schlott, B.; Schutkowski, M.; Malesevic, M.; Fischer, G.
Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts
Biol. Chem.
394
1057-1067
2013
Homo sapiens
Manually annotated by BRENDA team
Kallinen, A.; Todorov, B.; Kallionpaeae, R.; Baeck, S.; Sarparanta, M.; Raki, M.; Garcia-Horsman, J.A.; Bergstroem, K.A.; Wallen, E.A.; Maennistoe, P.T.; Airaksinen, A.J.
Synthesis and biological evaluation of novel 123I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo
Eur. J. Med. Chem.
79
436-445
2014
Mus musculus
Manually annotated by BRENDA team
Jambunathan, K.; Watson, D.S.; Endsley, A.N.; Kodukula, K.; Galande, A.K.
Comparative analysis of the substrate preferences of two post-proline cleaving endopeptidases, prolyl oligopeptidase and fibroblast activation protein alpha
FEBS Lett.
586
2507-2512
2012
Homo sapiens
Manually annotated by BRENDA team
Matsuda, T.; Sakaguchi, M.; Tanaka, S.; Yoshimoto, T.; Takaoka, M.
Prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein that regulates genotoxic stress-induced cell death
Int. J. Biochem. Cell Biol.
45
850-857
2013
Homo sapiens
Manually annotated by BRENDA team
Voeller, G.H.; Krawczyk, B.; Ensle, P.; Suessmuth, R.D.
Involvement and unusual substrate specificity of a prolyl oligopeptidase in class III lanthipeptide maturation
J. Am. Chem. Soc.
135
7426-7429
2013
Kribbella flavida
Manually annotated by BRENDA team
Duan, L.; Ying, G.; Danzer, B.; Perez, R.E.; Shariat-Madar, Z.; Levenson, V.V.; Maki, C.G.
The prolyl peptidases PRCP/PREP regulate IRS-1 stability critical for rapamycin-induced feedback activation of PI3K and AKT
J. Biol. Chem.
289
21694-21705
2014
Homo sapiens
Manually annotated by BRENDA team
Savolainen, M.H.; Yan, X.; Myoehaenen, T.T.; Huttunen, H.J.
Prolyl oligopeptidase enhances alpha-synuclein dimerization via direct protein-protein interaction
J. Biol. Chem.
290
5117-5126
2015
Sus scrofa
Manually annotated by BRENDA team
Myoehaenen, T.T.; Pyykkoe, E.; Maennistoe, P.T.; Carpen, O.
Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors
J. Histochem. Cytochem.
60
706-715
2012
Homo sapiens
Manually annotated by BRENDA team
Kang, C.; Yu, X.W.; Xu, Y.
Purification and characterization of a prolyl endopeptidase isolated from Aspergillus oryzae
J. Ind. Microbiol. Biotechnol.
41
49-55
2014
Aspergillus oryzae
Manually annotated by BRENDA team
Kang, C.; Yu, X.W.; Xu, Y.
Cloning and expression of a novel prolyl endopeptidase from Aspergillus oryzae and its application in beer stabilization
J. Ind. Microbiol. Biotechnol.
42
263-272
2015
Aspergillus oryzae, Aspergillus oryzae WX2011
Manually annotated by BRENDA team
Poplawski, S.E.; Lai, J.H.; Li, Y.; Jin, Z.; Liu, Y.; Wu, W.; Wu, Y.; Zhou, Y.; Sudmeier, J.L.; Sanford, D.G.; Bachovchin, W.W.
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase
J. Med. Chem.
56
3467-3477
2013
Homo sapiens
Manually annotated by BRENDA team
Chen, J.T.; Chao, M.L.; Wen, C.Y.; Chu, W.S.
Screening, purification, and characterization of an extracellular prolyl oligopeptidase from Coprinopsis clastophylla
J. Microbiol.
50
652-659
2012
Coprinopsis clastophylla
Manually annotated by BRENDA team
Hannula, M.J.; Myoehaenen, T.T.; Tenorio-Laranga, J.; Maennistoe, P.T.; Garcia-Horsman, J.A.
Prolyl oligopeptidase colocalizes with alpha-synuclein, beta-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinsons and Alzheimers diseases
Neuroscience
242
140-150
2013
Homo sapiens
Manually annotated by BRENDA team
Adolpho, L.O.; Marin, D.; Puigpinos, A.; Mendieta, L.; Tarrago, T.; Morel, A.F.; Giralt, E.; Dalcol, I.I.
In vitro evaluation of caffeoyl and cinnamoyl derivatives as potential prolyl oligopeptidase inhibitors
Planta Med.
79
1531-1535
2013
Homo sapiens
Manually annotated by BRENDA team
Kaushik, S.; Etchebest, C.; Sowdhamini, R.
Decoding the structural events in substrate-gating mechanism of eukaryotic prolyl oligopeptidase using normal mode analysis and molecular dynamics simulations
Proteins
82
1428-1443
2014
Aeromonas caviae, Myxococcus xanthus, Sus scrofa (P23687), Sus scrofa, Novosphingobium capsulatum (Q9ZNM8)
Manually annotated by BRENDA team
Wadhawan, M.; Tiwari, S.; Sharma, S.; Rathaur, S.
Identification and characterization of a novel prolyl oligopeptidase in filarial parasite Setaria cervi
Biochem. Biophys. Res. Commun.
495
2235-2241
2018
Setaria cervi
Manually annotated by BRENDA team
Czekster, C.M.; Naismith, J.H.
Kinetic landscape of a peptide bond-forming prolyl oligopeptidase
Biochemistry
56
2086-2095
2017
Galerina marginata
Manually annotated by BRENDA team
Ellis-Guardiola, K.; Rui, H.; Beckner, R.L.; Srivastava, P.; Sukumar, N.; Roux, B.; Lewis, J.C.
Crystal structure and conformational dynamics of Pyrococcus furiosus prolyl oligopeptidase
Biochemistry
58
1616-1626
2019
Pyrococcus furiosus (Q51714), Pyrococcus furiosus
Manually annotated by BRENDA team
Tokai, S.; Bito, T.; Shimizu, K.; Arima, J.
Methionine residues lining the substrate pathway in prolyl oligopeptidase from Pleurotus eryngii play an important role in substrate recognition
Biosci. Biotechnol. Biochem.
82
1107-1115
2018
Pleurotus eryngii
Manually annotated by BRENDA team
Lopez, A.; Herranz-Trillo, F.; Kotev, M.; Gairi, M.; Guallar, V.; Bernado, P.; Millet, O.; Tarrago, T.; Giralt, E.
Active-site-directed inhibitors of prolyl oligopeptidase abolish its conformational dynamics
ChemBioChem
17
913-917
2016
Homo sapiens
Manually annotated by BRENDA team
Shetty, R.; Vestergaard, M.; Jessen, F.; Haegglund, P.; Knorr, V.; Koehler, P.; Prakash, H.S.; Hobley, T.J.
Discovery, cloning and characterisation of proline specific prolyl endopeptidase, a gluten degrading thermo-stable enzyme from Sphaerobacter thermophiles
Enzyme Microb. Technol.
107
57-63
2017
Sphaerobacter thermophilus (D1C7Y4), Sphaerobacter thermophilus DSM 20745 (D1C7Y4), Sphaerobacter thermophilus S 6022 (D1C7Y4)
Manually annotated by BRENDA team
Cahlikova, L.; Hulova, L.; Hrabinova, M.; Chlebek, J.; Hostalkova, A.; Adamcova, M.; Safratova, M.; Jun, D.; Opletal, L.; Locarek, M.; Macakova, K.
Isoquinoline alkaloids as prolyl oligopeptidase inhibitors
Fitoterapia
103
192-196
2015
Homo sapiens
Manually annotated by BRENDA team
Jaako, K.; Waniek, A.; Parik, K.; Klimaviciusa, L.; Aonurm-Helm, A.; Noortoots, A.; Anier, K.; Van Elzen, R.; Gerard, M.; Lambeir, A.M.; Rossner, S.; Morawski, M.; Zharkovsky, A.
Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro
J. Cell Sci.
129
3792-3802
2016
Homo sapiens
Manually annotated by BRENDA team
Eugster, P.J.; Salamin, K.; Grouzmann, E.; Monod, M.
Production and characterization of two major Aspergillus oryzae secreted prolyl endopeptidases able to efficiently digest proline-rich peptides of gliadin
Microbiology
161
2277-2288
2015
Aspergillus oryzae
Manually annotated by BRENDA team
Tang, J.; Yan, L.; Weng, L.; Sun, L.; Liu, G.; Cao, M.
Purification and characterization of a prolyl endopeptidase from round scad (Decapterus maruadsi) skeletal muscle and its role in collagen degradation
Mod. Food Sci. Technol.
32
122-129
2016
Decapterus maruadsi
-
Manually annotated by BRENDA team
Xu, P.; Bao, R.; Zhang, Y.; Lu, E.; Feng, F.; Zhang, L.; Li, J.; Wang, J.; Tan, X.; Tang, M.; Hu, C.; Li, G.; Zhang, C.
Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells
Mol. Reprod. Dev.
86
714-726
2019
Mus musculus
Manually annotated by BRENDA team
Hostalkova, A.; Opletal, L.; Kunes, J.; Novak, Z.; Hrabinova, M.; Chlebek, J.; Cegan, L.; Cahlikova, L.
Alkaloids from Peumus boldus and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity
Nat. Prod. Commun.
10
577-580
2015
Homo sapiens
Manually annotated by BRENDA team
Maruyama, Y.; Matsubara, S.; Kimura, A.P.
Mouse prolyl oligopeptidase plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast
Placenta
53
8-15
2017
Mus musculus
Manually annotated by BRENDA team
Fajtova, P.; Stefanic, S.; Hradilek, M.; Dvorak, J.; Vondrasek, J.; Jilkova, A.; Ulrychova, L.; McKerrow, J.H.; Caffrey, C.R.; Mares, M.; Horn, M.
Prolyl oligopeptidase from the blood fluke Schistosoma mansoni From functional analysis to anti-schistosomal inhibitors
PLoS Negl. Trop. Dis.
9
e0003827
2015
Homo sapiens, Schistosoma mansoni (W8GKU3), Schistosoma mansoni
Manually annotated by BRENDA team
Van Elzen, R.; Schoenmakers, E.; Brandt, I.; Van Der Veken, P.; Lambeir, A.
Ligand-induced conformational changes in prolyl oligopeptidase A kinetic approach
Protein Eng. Des. Sel.
30
219-226
2017
Sus scrofa (P23687), Sus scrofa, Homo sapiens (P48147), Homo sapiens
Manually annotated by BRENDA team
Kocadag Kocazorbaz, E.; Zihnioglu, F.
Purification, characterization and the use of recombinant prolyl oligopeptidase from Myxococcus xanthus for gluten hydrolysis
Protein Expr. Purif.
129
101-107
2017
Myxococcus xanthus, Myxococcus xanthus ATCC 25232
Manually annotated by BRENDA team