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3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.26 prolyl oligopeptidase

Specific Activity

Specific Activity on EC 3.4.21.26 - prolyl oligopeptidase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.000000452
-
testicular seminoma, membrane-bound enzyme
0.000000465
-
healthy kidney, membrane-bound enzyme
0.000000507
-
clear cell renal cell carinoma, membrane-bound enzyme
0.000000567
-
healthy renal pelvis, membrane-bound enzyme
0.000000613
-
healthy thyroid, membrane-bound enzyme
0.000000634
-
healthy kidney, membrane-bound enzyme
0.000000696
-
healty testis, membrane-bound enzyme
0.000000737
-
healthy colorectum, membrane-bound enzyme
0.000000748
-
chromophobe renal cell carcinoma, membrane-bound enzyme
0.000000997
-
colorectal adenocarcinoma, membrane-bound enzyme
0.000001077
-
urothelial carcinoma of the renal pelvis, membrane-bound enzyme
0.000001182
-
healthy thyroid, cytosolic enzyme
0.000001236
-
head and neck squamous cell carcinoma, membrane-bound enzyme
0.000001323
-
squamous cell, membrane-bound enzyme
0.00000159
-
healty testis, cytosolic enzyme
0.000001694
-
papillary thyroid carcinoma, membrane-bound enzyme
0.000002733
-
healthy kidney, cytosolic enzyme
0.000002735
-
colorectal adenomatous poly, membrane-bound enzyme
0.000002849
-
testicular seminoma, cytosolic enzyme
0.000003163
-
healthy renal pelvis, cytosolic enzyme
0.000003179
-
chromophobe renal cell carcinoma, cytosolic enzyme
0.000003542
-
healthy kidney, cytosolic enzyme
0.000003679
-
clear cell renal cell carinoma, cytosolic enzyme
0.000004097
-
papillary thyroid carcinoma, cytosolic enzyme
0.000006846
-
squamous cell, cytosolic enzyme
0.000007659
-
urothelial carcinoma of the renal pelvis, cytosolic enzyme
0.000009287
-
healthy colorectum, cytosolic enzyme
0.00001134
-
head and neck squamous cell carcinoma, cytosolic enzyme
0.00001173
-
colorectal adenocarcinoma, cytosolic enzyme
0.00002357
-
colorectal adenomatous poly, cytosolic enzyme
0.00017
-
high-density membranes, membrane-bound POP activity of different-density membrane fractions obtained by sucrose gradient centrifugation
0.0002
-
washed membranes, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.00045
-
medium-density membranes, membrane-bound POP activity of different-density membrane fractions obtained by sucrose gradient centrifugation
0.0005
0.00061
-
low-density membranes, membrane-bound POP activity of different-density membrane fractions obtained by sucrose gradient centrifugation
0.001
-
crude extract, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.0014
-
unwashed membranes, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.0033
-
Triton X-100 extraction, purification of mPOP from a total membrane preparation
0.0048
-
4 M NaCl wash, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.0074
-
DEAE, purification of mPOP from a total membrane preparation
0.009
-
0.5 M NaCl wash, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.01
purified enzyme
0.0138
-
water wash, POP activity partitioning during membrane preparation crude extract and membrane wash effects on recovered activity
0.039
-
phenyl-sepharose, purification of mPOP from a total membrane preparation
0.096
-
pH 7.4, 22°C, substrate benzyloxycarbonyl-Gly-L-Pro-doxorubicin
0.169
-
hydroxylapatite, purification of mPOP from a total membrane preparation
0.18
-
supernatant, using benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide as substrate, at pH 8.0 and 37°C
0.813
-
pH 7.4, 22°C, substrate benzyloxycarbonyl-Gly-L-Pro-melphalan
0.857
-
second DEAE, purification of mPOP from a total membrane preparation
2.87
-
-
225.93
-
after 44.326fold purification, at pH 8.0 and 37°C
226
-
60.3fold purified enzyme, at pH 7.5 and 37°C
24.7
-
-
3.8
-
homogenate, at pH 7.5 and 37°C
3650
-
after 73fold purification, at pH 5.0 and 35°C
4.066
-
pH 7.4, 22°C, substrate benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin
45
-
-
5.097
-
crude cytosolic extract, at pH 8.0 and 37°C
5.4
-
-
5.53
-
-
50
-
crude extract, at pH 5.0 and 35°C
52.1
-
after 285fold purification, using benzyloxycarbonyl-Gly-L-Pro-4-nitroanilide as substrate, at pH 8.0 and 37°C
61.3
-
after 285fold purification, using benzyloxycarbonyl-Gly-L-Pro-7-amido-4-methylcoumarin as substrate, at pH 8.0 and 37°C
additional information