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malfunction
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enzyme associated with schizophrenia, bipolar affective disorder and related neuropsychiatric disorders
malfunction
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involvement of enzyme in mechanisms of neoplastic processes suggested
malfunction
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inhibition or knockdown of prolyl oligopeptidase leads to suppression of NB-1 cell growth, and the effect is accompanied by G0/G1 arrest
malfunction
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depletion/inhibition of prolylcarboxypeptidase (PRCP)/prolylendopeptidase (PREP) suppresses rapamycin-induced activation of PI3K/AKT with consequent additive/synergistic cytotoxicity
malfunction
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enzyme inhibition induces calcium signaling via phospholipase c stimulation which further triggers mitochondrial mediated apoptosis in filarial parasites
metabolism
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prolyl endopeptidase is involved in collagen breakdown
metabolism
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prolyl oligopeptidase is a second-step enzyme in the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from thymosin beta4, and it has autoregulatory effect in the first step
physiological function
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implicated in neurodegeneration and in modulation of the inflammatory response
physiological function
important function in learning and memory processes, psychological disorders and neurodegenerative diseases
physiological function
important role in host interactions
physiological function
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involved in memory-related function
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
participates in several aspects and functions of the central nervous system, including learning, memory, mood, hypertension and eating, and in some neurodegenerative diseases such as Alzheimer`s and Parkinson`s diseases
physiological function
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regulates appetite or milk production
physiological function
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regulation of the brain levels of biologically active peptide substrates and phosphatidylinosital system, influence on memory and mood, possible role in motor functions
physiological function
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cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase
physiological function
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prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-Ser-Asp-Lys-Pro from its precursor thymosin beta4
physiological function
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prolyl oligopeptidase participates in cell cycle progression in human NB-1 neuroblastoma cells
physiological function
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prolyl oligopeptidase with thymosin beta4 significantly induces angiogenesis of human umbilical vein endothelial cells. Prolyl oligopeptidase has a pro-angiogenic role via the release of acetyl-N-L-Ser-L-Asp-L-Lys-L-Pro from its precursor thymosin beta4
physiological function
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the enzyme is implicated in neuropeptide processing
physiological function
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PRCP and PREP regulate IRS-1 stability and PI3K/AKT activation in pancreatic cancer
physiological function
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prolyl oligopeptidase is a glyceraldehyde-3-phosphate dehydrogenase-binding protein that regulates genotoxic stress-induced cell death. Prolyl oligopeptidase mediates glyceraldehyde-3-phosphate dehydrogenase nuclear localization
physiological function
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the enzyme is associated with secretory processes as well as in reproduction
physiological function
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enzyme overexpression increases progesterone secretion, increases ERK1/2 phosphorylation and increases the expression of steroidogenic factor 1. The enzyme regulates progesterone secretion by stimulating the expression of CYP11A, 3beta-hydroxysteroid dehydrogenase, and steroidogenic acute regulatory protein in luteal cells
physiological function
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increased enzyme levels promote epidermal growth factor receptor signaling, which in turn activates matrix metalloproteinase-9
physiological function
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the enzyme participates in post-mortem fish collagen degradation
physiological function
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the enzyme plays a role in trophoblast stem cell differentiation into trophoblast giant cell and spongiotrophoblast
additional information
human PREP behaves identically to the porcine homologue, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV)
additional information
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human PREP behaves identically to the porcine homologue, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV)
additional information
human PREP behaves identically to the porcine homologue, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV)
additional information
-
human PREP behaves identically to the porcine homologue, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV)