Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide | IC50: 54 nM | Sus scrofa | |
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine (L-proline methyl ester) amide | IC50: 640 nM | Sus scrofa | |
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide | IC50: 0.61 nM, log P: 0.2, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid 2(S)-(cyclopentylcarbonyl)pyrrolidine L-prolyl-pyrrolidine amide | IC50: 14 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid 2(S)-(cylcohexanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | IC50: 0.72 nM | Sus scrofa | |
isophthalic acid 2(S)-(cylcopentanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | IC50: 1.1 nM, log P: 0.8, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide | IC50: 1.2 nM | Sus scrofa | |
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | IC50: 4.2 nM, log P: -0.6, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-pyrrolidine amide | IC50: 65 nM | Sus scrofa | |
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | IC50: 1.3 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-pyrrolidine amide | IC50: 18 nM | Sus scrofa | |
isophthalic acid 2(S)-isobutanoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | IC50: 1.6 nM, log P: 0.3, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid bis(L-prolyl-pyrrolidine) amide | IC50: 26 nM, log O = -0.2, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid bis-2(S)-(cyclopentanecarbonyl)pyrrolidine amide | IC50: 78 nM, log P: 2.7, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | |
isophthalic acid bis-2(S)-acetylpyrrolidine amide | 54% inhibition at 0.1 nM | Sus scrofa | |
isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide | IC50: 0.39 nM | Sus scrofa | |
isophthalic acid L-prolyl-2(S)-cyanopyrrolidine L-prolyl-pyrrolidine amide | IC50: 1.5 nM | Sus scrofa | |
isophthalic acid L-prolyl-pyrrolidine L-prolyl-L-prolinal amide | IC50: 1.3 nM | Sus scrofa | |
isophthalic acid L-prolylbenzylamine L-prolyl-pyrrolidine amide | IC50: 31 nM | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0194 | - |
Ala-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.0207 | - |
Gly-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.0229 | - |
Arg-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.04 | - |
Asp-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.043 | - |
benzyloxycarbonyl-Ala-Ala-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.0437 | - |
benzyloxycarbonyl-Ala-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.16 | - |
benzyloxycarbonyl-Gly-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pyrococcus furiosus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | Ala-Pro + p-nitroaniline | - |
? | |
Arg-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | Arg-Pro + p-nitroaniline | - |
? | |
Asp-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | Asp-Pro + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Ala-Ala-p-nitroanilide + H2O | - |
Pyrococcus furiosus | benzyloxycarbonyl-Ala-Ala + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Ala-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | benzyloxycarbonyl-Ala-Pro + p-nitroaniline | - |
? | |
benzyloxycarbonyl-Gly-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | benzyloxycarbonyl-Gly-Pro + p-nitroaniline | - |
? | |
Gly-Pro-p-nitroanilide + H2O | - |
Pyrococcus furiosus | Gly-Pro + p-nitroaniline | - |
? | |
succinyl-Gly-Pro-4-methylcoumaryl-7-amide + H2O | - |
Sus scrofa | succinyl-Gly-Pro + 7-amino-4-methylcoumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
POP | - |
Pyrococcus furiosus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
Arg-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.06 | - |
Gly-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.073 | - |
Asp-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
0.079 | - |
Ala-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
2.5 | - |
benzyloxycarbonyl-Ala-Ala-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
16.9 | - |
benzyloxycarbonyl-Gly-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus | |
17.9 | - |
benzyloxycarbonyl-Ala-Pro-p-nitroanilide | pH 7.5, 85°C | Pyrococcus furiosus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000039 | - |
IC50: 0.39 nM | Sus scrofa | isophthalic acid L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine L-prolyl-pyrrolidine amide | |
0.00000061 | - |
IC50: 0.61 nM, log P: 0.2, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide | |
0.00000072 | - |
IC50: 0.72 nM | Sus scrofa | isophthalic acid 2(S)-(cylcohexanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | |
0.0000011 | - |
IC50: 1.1 nM, log P: 0.8, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-(cylcopentanecarbonyl)pyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | |
0.0000012 | - |
IC50: 1.2 nM | Sus scrofa | isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide | |
0.0000013 | - |
IC50: 1.3 nM | Sus scrofa | isophthalic acid L-prolyl-pyrrolidine L-prolyl-L-prolinal amide | |
0.0000013 | - |
IC50: 1.3 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | |
0.0000015 | - |
IC50: 1.5 nM | Sus scrofa | isophthalic acid L-prolyl-2(S)-cyanopyrrolidine L-prolyl-pyrrolidine amide | |
0.0000016 | - |
IC50: 1.6 nM, log P: 0.3, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-isobutanoylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | |
0.0000042 | - |
IC50: 4.2 nM, log P: -0.6, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-2(S)-cynaopyrrolidine amide | |
0.000014 | - |
IC50: 14 nM, log P: 1.1, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid 2(S)-(cyclopentylcarbonyl)pyrrolidine L-prolyl-pyrrolidine amide | |
0.000018 | - |
IC50: 18 nM | Sus scrofa | isophthalic acid 2(S)-benzoylpyrrolidine L-prolyl-pyrrolidine amide | |
0.000026 | - |
IC50: 26 nM, log O = -0.2, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid bis(L-prolyl-pyrrolidine) amide | |
0.000031 | - |
IC50: 31 nM | Sus scrofa | isophthalic acid L-prolylbenzylamine L-prolyl-pyrrolidine amide | |
0.000054 | - |
IC50: 54 nM | Sus scrofa | isophthalic acid (L-proline methyl ester) L-prolyl-pyrrolidine amide | |
0.000065 | - |
IC50: 65 nM | Sus scrofa | isophthalic acid 2(S)-acetylpyrrolidine L-prolyl-pyrrolidine amide | |
0.000078 | - |
IC50: 78 nM, log P: 2.7, the log P value is a first prediction of the blood-brain barrier penetrability | Sus scrofa | isophthalic acid bis-2(S)-(cyclopentanecarbonyl)pyrrolidine amide | |
0.00064 | - |
IC50: 640 nM | Sus scrofa | isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine (L-proline methyl ester) amide |