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3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.26 prolyl oligopeptidase

KI Value

KI Value on EC 3.4.21.26 - prolyl oligopeptidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00087
((8'Z)-pentadecenyl)-salicylic acid
-
-
0.00000036
(2S)-1-[1-(3-[[(2S)-2-(cyclopentylcarbonyl)pyrrolidin-1-yl]carbonyl]benzoyl)-L-prolyl]pyrrolidine-2-carbonitrile
brain
0.00000015
(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidine-2-carbaldehyde
-
pH 7.0, 23°C
0.00000039
(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-L-prolyl]pyrrolidine-2-carbonitrile
-
pH 7.0, 23°C
0.000001
(2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
pH 7.5, 37°C, recombinant enzyme
0.0000118
(2S,2'S)-1,1'-(benzene-1,3-diyldicarbonyl)bis[2-(pyrrolidin-1-ylcarbonyl)pyrrolidine]
-
pH 7.0, 23°C
0.0000272
1,2,3,4,6-pentagalloyl glucopyranoside
-
-
0.000405
1,2,3,6-tetragalloyl alloside
-
-
0.00249
1,2,3-trigalloyl glucopyranoside
-
-
0.000203
1,2,6-trigalloyl alloside
-
-
0.0000194 - 0.000194
1,2,6-trigalloyl glucopyranoside
0.0000004
1,3,6-trigalloyl alloside
-
-
0.000000079
2-hydroxy-1-[(2S)-1-[1-[(3-[[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]carbonyl]phenyl)carbonyl]-D-prolyl]pyrrolidin-2-yl]ethanone
-
pH 7.0, 23°C
5
4-(2-aminoethyl)-benzenesulfonyl fluoride
-
pH 7.5, 85°C
0.0000042
4-(4-[123I]iodophenyl)butanoyl-L-prolyl-2(S)-cyanopyrrolidine
-
pH and temperature not specified in the publication
0.000000026
4-phenylbutanoyl-5(R)-methyl-L-Pro-2(S)-(hydroxyacetyl)pyrrolidine
-
pH 7.0, 30°C
0.000000022
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
-
pH 7.0, 23°C
0.00000039
4-phenylbutanoyl-5(R)-t-butyl-L-prolyl-pyrrolidine
-
pH 7.0, 23°C
0.000000015
4-phenylbutanoyl-5(R)-tert-butyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
-
pH 7.0, 30°C
0.000000015
4-phenylbutanoyl-5(R)-tert-butyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
at 25°C between pH 5.5 and 9.5
0.000000018
4-phenylbutanoyl-L-Pro-2(S)-(hydroxyacetyl)-pyrrolidine
-
pH 7.0, 30°C
0.00000002
4-phenylbutanoyl-L-prolyl-2(S)-cyanopyrrolidine
at 25°C between pH 5.5 and 9.5
0.000000023
4-phenylbutanoyl-L-prolyl-2(S)cyanopyrrolidine
-
pH 7.0, 23°C
0.00000097
4-phenylbutanoyl-L-prolyl-pyrrolidine
-
pH 7.0, 23°C
0.0008
6-((10'Z)-heptadecenyl)salicylic acid
-
-
0.0008
6-(10Z-heptadecenyl)salicylic acid
-
pH 7.0, 37°C
0.00087
6-(8Z-pentadecenyl)salicylic acid
-
pH 7.0, 37°C
0.000033
9H-fluoren-9-ylmethyl [(2S)-5-carbamimidamido-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopentan-2-yl]carbamate
-
brain
0.000074
acetonyl geraniin
-
-
0.0913
arachidonic acid
-
37°C, pH 7.0
0.00000073
ARI-3099
-
at 25°C, pH not specified in the publication
0.0000031
ARI-3531
-
at 25°C, pH not specified in the publication
0.000003
benzyl (1S,2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]cyclohexanecarboxylate
-
brain
0.0029
benzyl (2S)-2-(1,3-oxazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate
-
brain
0.00161
benzyl (2S)-2-[(1-oxido-1,3-thiazolidin-3-yl)carbonyl]pyrrolidine-1-carboxylate
-
brain
0.042
benzyl (2S)-2-[[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
-
brain
0.0000024
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-2,3-dihydro-1H-indole-1-carboxylate
-
brain
0.0000034
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]-5-oxopyrrolidine-1-carboxylate
-
brain
0.00000035 - 0.000014
benzyl (2S)-2-[[(2S)-2-formylpyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
0.0002
benzyl [(3R,6R,7aS)-3-cyano-5-oxohexahydropyrrolo[2,1-b][1,3]thiazol-6-yl]carbamate
-
human brain
0.07
benzyl [2-[(2S)-2-(chloroacetyl)pyrrolidin-1-yl]-2-oxoethyl]carbamate
-
brain
0.000000055
benzylcarbamoyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine
at 25°C between pH 5.5 and 9.5
0.00000035
benzyloxycarbonyl-Pro-prolinal
-
-
0.000212
corilagin
-
-
0.00000015
cyclopent-2-ene-1,2-dicarboxylic acid 2-benzylamide 1-[2(S)-(hydroxyacetyl)-H-pyrrolidine]amide
at 25°C between pH 5.5 and 9.5
0.089
docosahexaenoic acid
-
37°C, pH 7.0
0.2475
eicosapentaenoic acid
-
37°C, pH 7.0
0.0000184
elaeocarpusin
-
-
0.0000046
euphorscopin
-
-
0.0000171
geraniin
-
-
0.000129
helioscopin B
-
-
0.000102
helioscopinin A
-
-
0.000098
helioscopinin B
-
-
0.000000048
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine amide
-
pH 7.0, 23°C
0.00000036
isophthalic acid 2(S)-(cyclopentanecarbonyl)pyrrolidine-L-prolyl-2(S)-cyanopyrrolidine amide
-
pH 7.0, 23°C
0.00079
jolkinin
-
-
0.00000083
JTP-4819
-
-
0.000000023
KYP-2047
-
pH and temperature not specified in the publication
0.051
linoleic acid
-
37°C, pH 7.0
0.000441
macranganin
-
-
0.278
N-succinyl-Gly-Pro-OH
-
-
0.0267
oleic acid
-
37°C, pH 7.0
0.000012
ONO-1603
0.00000026 - 0.0000009
phenyl (2S)-2-(((2S)-2-(1,3-thiazol-2-ylcarbonyl)pyrrolidin-1-yl)carbonyl)pyrrolidine-1-carboxylate
0.000072 - 0.000083
phenyl (2S)-2-(((2S)-2-(isoxazol-3-ylcarbonyl)pyrrolidin-yl)carbonyl)pyrrolidine-1-carboxylate
0.00000021 - 0.00000048
phenyl (2S)-2-([(2S)-2-[(5-phenylisoxazol-3-yl)carbonyl]pyrrolidin-1-yl]carbonyl)pyrrolidine-1-carboxylate
0.00000028 - 0.0000008
phenyl (2S)-2-[[(2S)-2-([5-[(2E)-3-phenylprop-2-en-1-yl]isoxazol-3-yl]carbonyl)pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
0.00000045 - 0.0000015
phenyl (2S)-2-[[(2S)-2-[[5-(trimethylsilyl)isoxazol-3-yl]carbonyl]pyrrolidin-1-yl]carbonyl]pyrrolidine-1-carboxylate
0.0000094
rugosin E
-
-
0.000001 - 0.00003
S 17092
0.0000015
S-17092
-
-
0.0000072
SUAM-1221
-
-
0.000091
supinanin
-
-
0.311 - 0.42
tasidotin
0.001717
teracatain
-
-
0.00554
tert-butyl [(2S)-3-methyl-1-(1,3-thiazolidin-3-yl)-1-thioxobutan-2-yl]carbamate
-
human placenta
0.00000095
Y-29794
-
rat cortex
0.0000002
Z-Pro-prolinal
at 25°C between pH 5.5 and 9.5
0.0029
ZTTA
-
rat brain
0.0000015
[(1R,2R)-2-phenylcyclopropyl][(2S,3aS,7aS)-2-(1,3-thiazolidin-3-ylcarbonyl)octahydro-1H-indol-1-yl]methanone
-
-
0.0000022
[(2R)-1-[N-(2,5-dichlorobenzoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
-
additional information
benzyl (2S)-2-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidine-1-carboxylate