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3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.26 prolyl oligopeptidase

pH Range

pH Range on EC 3.4.21.26 - prolyl oligopeptidase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2 - 6
-
isoform S28A
2 - 7
-
isoform S28B
3 - 8
-
over 60% of the maximum activity is retained between pH 3.0 and 8.0
3 - 9
-
-
5 - 8
the enzyme is most active from pH 5.0-8.0
5.5 - 7.5
-
-
6 - 10
about 30% activity at pH 6.0, about 70% activity at pH 7.0, 100% activity at pH 8.0, about 60% activity at pH 9.0, about 40% activity at pH 10.0, no enzyme activity below pH 5.0
6 - 9
-
the activity of the enzyme is reduced by 50% and 60% at pH 6.0 and 9.0, respectively, compared to its maximal activity
6.5 - 9
about 50% of maximal activity at pH 6.5 and at pH 9.0
7 - 9
-
pH 7.0: about 55% of maximal activity, pH 9.0: about 30% of maximal activity, reaction with bradykinin
8 - 11
-
-
8.5 - 10
-
pH 8.5: about 40% of maximal activity, pH 10.0: about 80% of maximal activity, reaction with 2-aminobenzoyl-BKQRPPGFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)
additional information