3.4.21.26: prolyl oligopeptidase

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For detailed information about prolyl oligopeptidase, go to the full flat file.

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.26 prolyl oligopeptidase

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Results	in table
15	Activating Compound
1921	AA Sequence
28	Application
1	CAS Registry Number
40	Cloned(Commentary)
12	Crystallization (Commentary)
1563	Disease/ Diagnostics
8	Expression
34	General Information
6	General Stability
294	IC50 Value
923	Inhibitors
45	kcat/KM [mM/s]
96	Ki Value [mM]
178	KM Value [mM]
86	Localization
17	Metals/Ions
88	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
249	Organism
2	Oxidation Stability
38	PDB ID
82	pH Optimum
20	pH Range
12	pH Stability
18	pI Value
7	Posttranslational Modification
55	Protein Variants
58	Purification (Commentary)
27	Reaction
12	Reaction Type
249	Reference
1	Renatured (Commentary)
386	Source Tissue
77	Specific Activity [micromol/min/mg]
3	Storage Stability
733	Substrates and Products (Substrate)
65	Subunits
285	Synonyms
44	Temperature Optimum [°C]
3	Temperature Range [°C]
21	Temperature Stability [°C]
155	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 3.4.21.26 - prolyl oligopeptidase

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

25 - 37

Coprinopsis clastophylla

-

the enzyme is active over a temperature range of 25-37°C

732333

30 - 100

Thermococcus onnurineus

Q2QC90

25% of maximal activity within the range of 30-50°C, and at 100°C

683690

50 - 75

Sphaerobacter thermophilus

D1C7Y4

the enzyme shows high activity in the temperature range 50-75°C

753447