3.4.21.26: prolyl oligopeptidase

This is an abbreviated version!
For detailed information about prolyl oligopeptidase, go to the full flat file.

Word Map on EC 3.4.21.26

3.4.21.26

dipeptidyl

stroma

cancer-associated

aminopeptidase

neuropeptides

endopeptidases

neurotensin

proline-containing

fapis

biodistribution

myofibroblasts

flavobacterium

celiac

beta-propeller

bradykinin

trh

dppiv

meningosepticum

3.4.14.5

18f-fdg

theranostic

exopeptidase

pyroglutamyl

phosphoramidon

amanita

amnesia

carcinoma-associated

peptidase-iv

pharmacology

ac-sdkp

seven-bladed

gluten-free

suvmean

gliadin

n-acetyl-seryl-aspartyl-lysyl-proline

bispecific

acylpeptide

medicine

nutrition

food industry

drug development

Reaction

Hydrolysis of --Pro-/- and to a lesser extent --Ala-/- in oligopeptides =

Synonyms

apPEP, cyproase I, EC 3.4.22.18, endoprolylpeptidase, eryngase, FAP, fibroblast activation protein, FlaP, glutenase, membrane-bound PE, More, mPOP, PE, PEP, PepO2, peptidase, postproline endo-, POP, POP Tb, POP Tc80, POPA, POPB, post proline cleaving enzyme, post prolyl cleaving enzyme, post-proline cleaving endopeptidase, post-proline cleaving enzyme, post-proline cutting enzyme, post-proline endopeptidase, postproline cleaving enzyme, postproline endopeptidase, postproline-cleaving enzyme, PPCE, PREP, PREPL A, proline endopeptidase, proline specific prolyl endopeptidase, proline-specific endopeptidase, proly endopeptidase, prolyl endopeptidase, prolyl endoprotease, prolyl oligopeptidase, prolyl oligopeptidase B, prolylendopeptidase, prost-proline cleaving enzyme, PsE, S28A, S28B, TNA1_POP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.26 prolyl oligopeptidase

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Results	in table
15	Activating Compound
1921	AA Sequence
28	Application
1	CAS Registry Number
40	Cloned(Commentary)
12	Crystallization (Commentary)
1563	Disease/ Diagnostics
8	Expression
34	General Information
6	General Stability
294	IC50 Value
923	Inhibitors
45	kcat/KM [mM/s]
96	Ki Value [mM]
178	KM Value [mM]
86	Localization
17	Metals/Ions
88	Molecular Weight [Da]
234	Natural Substrates/ Products (Substrates)
249	Organism
2	Oxidation Stability
38	PDB ID
82	pH Optimum
20	pH Range
12	pH Stability
18	pI Value
7	Posttranslational Modification
55	Protein Variants
58	Purification (Commentary)
27	Reaction
12	Reaction Type
249	Reference
1	Renatured (Commentary)
386	Source Tissue
77	Specific Activity [micromol/min/mg]
3	Storage Stability
733	Substrates and Products (Substrate)
65	Subunits
285	Synonyms
44	Temperature Optimum [°C]
3	Temperature Range [°C]
21	Temperature Stability [°C]
155	Turnover Number [1/s]

Metals Ions

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Metals Ions on EC 3.4.21.26 - prolyl oligopeptidase

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Ca2+

3 entries

Co2+

Sphaerobacter thermophilus

D1C7Y4

the enzyme is activated and stabilized by Co2+ (1 mM)

753447

Cu2+

Sus scrofa

692312

Fe2+

Coprinopsis clastophylla

activates

Mn2+

NaBr

activates. There are five non-productive binding sites for Cl-, and two for F- and Br-, suggesting that Cl- must bind differently from F- and Br-

722617

NaCl

3 entries

NaF

Pyrococcus furiosus

activates. There are five non-productive binding sites for Cl-, and two for F- and Br-, suggesting that Cl- must bind differently from F- and Br-

722617

Ni2+

Sus scrofa

692312

Zinc

Lactobacillus helveticus

Q8VTS9

the enzyme contains the zinc-dependent metalloprotease motif HEXXH

649381

Zn2+

Sus scrofa

692312

additional information

2 entries