3.1.6.2: steryl-sulfatase
This is an abbreviated version!
For detailed information about steryl-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.2
-
3.1.6.2
-
women
-
testosterone
-
androgen
-
adrenal
-
cortisol
-
estradiol
-
estrogen
-
androstenedione
-
sulphate
-
globulin
-
polycystic
-
ovary
-
fsh
-
x-linked
-
ovarian
-
postmenopausal
-
ichthyosis
-
progesterone
-
acth
-
aromatase
-
hyperandrogenism
-
neurosteroids
-
hirsutism
-
menstrual
-
hormone-binding
-
prolactin
-
luteinizing
-
17-hydroxyprogesterone
-
premenopausal
-
adrenarche
-
sulfotransferase
-
hormone-dependent
-
sulfamate
-
endocrinology
-
hyperandrogenemia
-
17beta-hydroxysteroid
-
hypothalamic-pituitary-adrenal
-
pubertal
-
pharmacology
-
21-hydroxylase
-
alpha-hydroxyprogesterone
-
17beta-hsds
-
dhea-s
-
virilization
-
tanner
-
11-deoxycortisol
-
allopregnanolone
-
sulfatases
-
kallmann
-
medicine
-
analysis
-
pregs
-
incidentalomas
- 3.1.6.2
- women
- testosterone
- androgen
- adrenal
- cortisol
- estradiol
- estrogen
- androstenedione
- sulphate
- globulin
-
polycystic
- ovary
- fsh
-
x-linked
- ovarian
-
postmenopausal
- ichthyosis
- progesterone
- acth
- aromatase
- hyperandrogenism
-
neurosteroids
- hirsutism
-
menstrual
-
hormone-binding
- prolactin
-
luteinizing
- 17-hydroxyprogesterone
-
premenopausal
-
adrenarche
-
sulfotransferase
-
hormone-dependent
- sulfamate
-
endocrinology
-
hyperandrogenemia
-
17beta-hydroxysteroid
-
hypothalamic-pituitary-adrenal
-
pubertal
- pharmacology
- 21-hydroxylase
-
alpha-hydroxyprogesterone
- 17beta-hsds
-
dhea-s
-
virilization
-
tanner
- 11-deoxycortisol
- allopregnanolone
-
sulfatases
-
kallmann
- medicine
- analysis
-
pregs
-
incidentalomas
Reaction
Synonyms
3-beta-hydroxysteroid sulfate sulfatase, arylsufatase, arylsulfatase C, ASC, AtsA, cholesterol sulfate sulfohydrolase, CHS-ase, dehydroepiandrosterone sulfatase, dehydroepiandrosterone sulfate sulfatase, DHEAS, E1-STS, ES, estrone sulfatase, More, neurosteroid sulfatase, NSS, oestrone sulfatase, phenolic steroid sulfatase, pregnenolone sulfatase, steroid 3-sulfatase, steroid sulfatase, steroid sulfate sulfohydrolase, steroid sulphatase, sterol sulfatase, sterolsulfate sulfohydrolase, Steryl-sulfate sulfohydrolase, STS, sulfatase, sterol
ECTree
3.1.6.2 steryl-sulfataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.1.6.2 - steryl-sulfatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
16alpha-hydroxydehydroepiandrosterone 3-sulfate + H2O
16alpha-hydroxydehydroepiandrosterone + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferol + sulfate
-
-
-
-
?
4-methylumbelliferyl-6-O-sulfate + H2O
4-methylumbelliferone + sulfate
-
-
-
-
?
7-dehydroepiandrosterone sulfate + H2O
7-dehydroepiandrosterone + sulfate
-
-
-
-
?
arylsulfates + H2O
? + sulfate
-
e.g. 3alpha sulfates of: 5alpha-androstane-17-one, 5beta-androstane-17-one, 3beta sulfates of: 5alpha-androstane-17-one, DELTA5-androstene 17-one, 5alpha-pregnane-20-one, DELTA5-pregnene-20-one
-
-
?
arzoxifene sulfate + H2O
arzoxifene + sulfate
-
product of sulfotransferase reaction on arzoxifene used in hormone replacement therapy
-
-
?
dehydroisoandrosterone 3-sulfate + H2O
dehydroisoandrosterone + sulfate
-
-
-
-
?
epitestosterone 17-sulfate + H2O
epitestosterone + sulfate
-
-
-
?
etiocholanolone 3-sulfate + H2O
etiocholanolone + sulfate
-
-
-
?
phenolphthalein disulfate + H2O
phenolphthalein monosulfate + sulfate
-
-
-
-
?
raloxifene sulfate + H2O
raloxifene + sulfate
-
product of sulfotransferase reaction on raloxifene used in hormone replacement therapy, the benzothiophene sulfate is substrate, the 4'-phenolic sulfate is no substrate for enzyme
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
3beta-hydroxyandrost-5-en-17-one + sulfate
-
-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
-
-
-
?
4-methylumbelliferyl sulfate + H2O
4-methylumbelliferone + sulfate
-
both s-form and f-form
-
-
?
cholesterol sulfate + H2O
cholesterol + sulfate
-
cholesterol sulfate metabolism, steroid sulfohydrolase pathway
-
-
?
cholesterol sulfate + H2O
cholesterol + sulfate
-
highly specific for cholesterol sulfate
-
-
?
dehydroandrosterone 3-sulfate + H2O
dehydroandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
only s-form
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
in adipose tissue, further concersion to bioactive androgens and estrogens
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
?
dehydroepiandrosterone 3-sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
conversion to androstenediol by 17beta-hydroxysteroid dehydrogenase type 1, androstenediol supports mammary tumor growth in rodents, or conversion to androstenedione, main substrate for aromatase in postmenopausal women
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to andgrogen testosterone or androstenediol, androgens stimulate growth of prostate cancer cells
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to androst-5-ene-3beta,17beta-diol (Adiol), an androgen with estrogenic properties, and thus a mitogen for the growth and development of hormome-dependent breast cancer
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
subsequent conversion to androst-5-ene-3beta,17beta-diol, an androgen with estrogenic properties, stimulating breast cancer growth
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to estradiol with 3beta-hydroxysteroid dehydrogenase, aromatase and 17beta-hydroxysteroid dehydrogenase
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to testosterone
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
androgen metabolism, dehydroepiandrosterone sulfate may play a part in the pathogenesis of androgenic alopecia
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
hydrolyzes dehydroepiandrosterone sulfate to its active, unsulfated form
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
oestrogen biosynthesis
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
1.5% of the activity with cholesterol sulfate
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
dehydroepiandrosterone is reduced to a diol by 17beta-HSD1, apart from estrone, the steroid sulfatase pathway is also responsible for the production of another steroid with estrogenic properties, namely androstenediol
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to testosterone or aromatisation to estrone
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
-
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
conversion to androstenediol by 17beta-hydroxysteroid dehydrogenase type 1, androstenediol supports mammary tumor growth in rodents, or conversion to androstenedione, main substrate for aromatase in postmenopausal women
-
?
dehydroepiandrosterone sulfate + H2O
dehydroepiandrosterone + sulfate
-
-
subsequent conversion to androst-5-ene-3beta,17beta-diol (Adiol), an androgen with estrogenic properties, and thus a mitogen for the growth and development of hormome-dependent breast cancer
-
?
epiandrosterone 3-sulfate + H2O
epiandrosterone + sulfate
-
-
-
?
estrone 3-sulfate + H2O
estrone + sulfate
-
hydrolyzes estrone 3-sulfate to its active, unsulfated form
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
135600, 135602, 135604, 135611, 135619, 135622, 135624, 645740, 645797, 656640, 656641, 656649, 656658, 681648, 691630, 702979, 703195, 705062, 705709, 714750, 714821, 714906, 716213, 716214
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
conversion to estradiol by 17beta-hydroxysteroid dehydrogenase type 1
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
estrogen estrone formed from androstenedione by cytochrome P450 enzyme aromatase, estrogen is a mitogen for growth and development of hormone-dependent breast cancer
-
?
estrone sulfate + H2O
estrone + sulfate
-
in breast cancer tissue 10 times more estrone originates from estrone sulfate than from androstenedione
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
subsequent conversion to biologically active estrogen estradiol, increased activity and expression of STS in hormone-dependent cancer cells, estradiol prerequisite for Ishikawa cell tumorgenesis in ovariectomized mouse model, estrogens are suggested as growth stimulators in prostate cancer cells as well, subsequent conversion to estradiol
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
subsequent conversion to estradiol
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
subsequent conversion to estradiol with 17beta-hydroxysteroid dehydrogenase
-
?
estrone sulfate + H2O
estrone + sulfate
-
STS converts the major circulating plasma estrogen estrone sulfate into the biologically active estrogene estrone, STS plays an important role in the in situ estrogen actions of various sex steroid-dependent tumors, peripheral STS plays a very important role in peripheral estrogen metabolism and actions in the human fetus
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
STS plays an important role in the in situ estrogen actions of estrogen-dependent human tissues and various sex steroid-dependent tumors, STS may be associated with the degree of atherosclerotic changes in the female aorta, transformation of the biologically inactive form of plasma estrogen in its active form
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
0.6% of the activity with cholesterol sulfate
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
estrone is locally produced from circulating inactive estrone sulfate by steroid sulfatase
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
subsequent conversion to estradiol
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
-
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
conversion to estradiol by 17beta-hydroxysteroid dehydrogenase type 1
-
?
estrone sulfate + H2O
estrone + sulfate
-
-
estrogen estrone formed from androstenedione by cytochrome P450 enzyme aromatase, estrogen is a mitogen for growth and development of hormone-dependent breast cancer
-
?
estrone sulfate + H2O
estrone + sulfate
STS within the Leydig cells of Sus scrofa is involved in modulation of testicular estrogen bioavailability
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
p-nitrophenyl-sulfate + H2O
p-nitrophenol + sulfate
-
arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein
-
-
?
pregnenolone sulfate + H2O
pregnenolone + sulfate
-
8.7% of the activity with cholesterol sulfate
-
-
?
steroid sulfate + H2O
steroid + sulfate
-
steroid sulfatase converts all steroid sulfates into their free steroid forms
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
135595, 135598, 135599, 135600, 135601, 135602, 135603, 135604, 135605, 135606, 135611, 135612, 135614, 135615, 135616, 135617, 135619, 135622, 135624, 135625, 135626, 135628
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
steroid sulfates + H2O
steroid + sulfate
-
also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site
-
-
?
testosterone 3-sulfate + H2O
testosterone + sulfate
-
-
-
?
additional information
?
-
-
NSS likely plays a key role in the regulation of the GABA-A receptor
-
-
?
additional information
?
-
-
biosynthesis of estrogens in breast tumor tissues of post-menopausal breast cancer patients, STS stimulates the growth and survival of estrogen-dependent breast tumors
-
-
?
additional information
?
-
-
ES is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol, hence, proliferation of hormone-dependent breast tumors
-
-
?
additional information
?
-
-
in vivo the activity of STS in the mammary myoepithelial cells may influence the availability of active, unsulfated hormones to the adjacent epithelial cells within mammary tissue and may have a role in the regulation of mammary growth and development
-
-
?
additional information
?
-
-
steroid sulfatase in the fallopian tube may be involved in controlling the local steroid environment, which appears to regulate aspects of the physiological reproductive function of the fallopian tube
-
-
?
additional information
?
-
-
STS may play an important role within the CNS
-
-
?
additional information
?
-
-
STS stimulates steroid production and increases steroidogenic acute regulatory protein expression
-
-
?
additional information
?
-
-
the action of STS makes a major contribution to the in situ estrogen production in breast tumors
-
-
?
additional information
?
-
-
desulfates a number of 3beta-hydroxysteroid sulfates
-
-
?
additional information
?
-
-
enzyme may be involved in the quality of eggs in patients with endometriosis
-
-
?
additional information
?
-
-
higher activity for 16-unsubstituted than for 16alpha-hydroxylated substrates
-
-
?
additional information
?
-
-
not: 17-sulfate ester of beta-estradiol or delta4-androstene-3-one-17alpha-ol
-
-
?
additional information
?
-
-
ovarian estrogen synthesis, the relative contribution of STS activity to ovarian steroidogenesis is unclear but may have important physiological and pathophysiological implications
-
-
?
additional information
?
-
-
enzyme is responsible for the removal of the sulfamoyl group from oestrogen sulfamates
-
-
?
