Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.1.6.2: steryl-sulfatase

This is an abbreviated version!
For detailed information about steryl-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.2

Reaction

3beta-hydroxyandrost-5-en-17-one 3-sulfate
+
H2O
=
3beta-hydroxyandrost-5-en-17-one
+
sulfate

Synonyms

3-beta-hydroxysteroid sulfate sulfatase, arylsufatase, arylsulfatase C, ASC, AtsA, cholesterol sulfate sulfohydrolase, CHS-ase, dehydroepiandrosterone sulfatase, dehydroepiandrosterone sulfate sulfatase, DHEAS, E1-STS, ES, estrone sulfatase, More, neurosteroid sulfatase, NSS, oestrone sulfatase, phenolic steroid sulfatase, pregnenolone sulfatase, steroid 3-sulfatase, steroid sulfatase, steroid sulfate sulfohydrolase, steroid sulphatase, sterol sulfatase, sterolsulfate sulfohydrolase, Steryl-sulfate sulfohydrolase, STS, sulfatase, sterol

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.2 steryl-sulfatase

Expression

Expression on EC 3.1.6.2 - steryl-sulfatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression increases upon stimulation with decidualisation media
shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression and activity of steroid sulfatase in breast cancer cells
-
Shu-Gan-Liang-Xue decoction down-regulates the expression of steroid sulfatase genes in human breast carcinoma MCF-7 cells in a dose-dependent manner
-
steroid sulfatase expression is upregulated in breast carcinomas
-
STS activity and gene expression are decreased during differentiation in cells treated with osteogenic supplement containing dexamethasone. The NFkappaB activators lipopolysaccharide and phorbol myristate acetate increase STS expression in undifferentiated and differentiated MG-63 cells, while the NFkappaB inhibitor BAY-11-7082 partially blocks these responses
trichostatin A treatment suppresses STS mRNA expression
-