3.1.6.2: steryl-sulfatase
This is an abbreviated version!
For detailed information about steryl-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.2
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3.1.6.2
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women
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testosterone
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androgen
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adrenal
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cortisol
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estradiol
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estrogen
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androstenedione
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sulphate
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globulin
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polycystic
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ovary
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fsh
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x-linked
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ovarian
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postmenopausal
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ichthyosis
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progesterone
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acth
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aromatase
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hyperandrogenism
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neurosteroids
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hirsutism
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menstrual
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hormone-binding
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prolactin
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luteinizing
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17-hydroxyprogesterone
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premenopausal
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adrenarche
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sulfotransferase
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hormone-dependent
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sulfamate
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endocrinology
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hyperandrogenemia
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17beta-hydroxysteroid
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hypothalamic-pituitary-adrenal
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pubertal
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pharmacology
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21-hydroxylase
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alpha-hydroxyprogesterone
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17beta-hsds
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dhea-s
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virilization
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tanner
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11-deoxycortisol
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allopregnanolone
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sulfatases
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kallmann
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medicine
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analysis
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pregs
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incidentalomas
- 3.1.6.2
- women
- testosterone
- androgen
- adrenal
- cortisol
- estradiol
- estrogen
- androstenedione
- sulphate
- globulin
-
polycystic
- ovary
- fsh
-
x-linked
- ovarian
-
postmenopausal
- ichthyosis
- progesterone
- acth
- aromatase
- hyperandrogenism
-
neurosteroids
- hirsutism
-
menstrual
-
hormone-binding
- prolactin
-
luteinizing
- 17-hydroxyprogesterone
-
premenopausal
-
adrenarche
-
sulfotransferase
-
hormone-dependent
- sulfamate
-
endocrinology
-
hyperandrogenemia
-
17beta-hydroxysteroid
-
hypothalamic-pituitary-adrenal
-
pubertal
- pharmacology
- 21-hydroxylase
-
alpha-hydroxyprogesterone
- 17beta-hsds
-
dhea-s
-
virilization
-
tanner
- 11-deoxycortisol
- allopregnanolone
-
sulfatases
-
kallmann
- medicine
- analysis
-
pregs
-
incidentalomas
Reaction
Synonyms
3-beta-hydroxysteroid sulfate sulfatase, arylsufatase, arylsulfatase C, ASC, AtsA, cholesterol sulfate sulfohydrolase, CHS-ase, dehydroepiandrosterone sulfatase, dehydroepiandrosterone sulfate sulfatase, DHEAS, E1-STS, ES, estrone sulfatase, More, neurosteroid sulfatase, NSS, oestrone sulfatase, phenolic steroid sulfatase, pregnenolone sulfatase, steroid 3-sulfatase, steroid sulfatase, steroid sulfate sulfohydrolase, steroid sulphatase, sterol sulfatase, sterolsulfate sulfohydrolase, Steryl-sulfate sulfohydrolase, STS, sulfatase, sterol
ECTree
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Activating Compound
Activating Compound on EC 3.1.6.2 - steryl-sulfatase
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17beta estradiol
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exposure to 17beta estradiol causes 9% increase of estrone 3-sulfate sulfatase activity in mammary myoepithelial cells after 6 days, but 70% reduction in MCF-7 cells
1alpha,25-dihydroxyvitamin D3
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upregulation of enzyme activity. In HL-60 cell, stimulation is augmented by retinoid X-receptor agonists, blocked by retinoid X-receptor specific antagonists, and retinoic acid receptor specific agonists and antagonist have no effect. In NB-4 cell, upregulation is unaffected by the specific classical nuclear vitamin D receptor and retinoid X-receptor antagonists, but is blocked by a plasma-membrane associated vitamin D receptor antagonist and increases by plasma-membrane associated vitamin D receptor agonists
interleukin 6
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plus tumor necrosis factor alpha, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
Tumor necrosis factor alpha
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plus interleucin 6, increases STS activity in mock transfected MCF-7 cells and further increases STS activity in transfected MCF-7 cells, activation occurs independently of STS promoter and enhancer elements, may activate via a post-translational modification of STS or by increasing substrate availability
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not activated by 2-mercaptoethanol, cysteine or dithiothreitol
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