3.1.6.2: steryl-sulfatase
This is an abbreviated version!
For detailed information about steryl-sulfatase, go to the full flat file.
![](word_maps/png/3_1_6_2.png)
Word Map on EC 3.1.6.2
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3.1.6.2
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women
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testosterone
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androgen
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adrenal
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cortisol
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estradiol
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estrogen
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androstenedione
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sulphate
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globulin
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polycystic
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ovary
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fsh
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x-linked
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ovarian
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postmenopausal
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ichthyosis
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progesterone
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acth
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aromatase
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hyperandrogenism
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neurosteroids
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hirsutism
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menstrual
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hormone-binding
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prolactin
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luteinizing
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17-hydroxyprogesterone
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premenopausal
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adrenarche
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sulfotransferase
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hormone-dependent
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sulfamate
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endocrinology
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hyperandrogenemia
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17beta-hydroxysteroid
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hypothalamic-pituitary-adrenal
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pubertal
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pharmacology
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21-hydroxylase
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alpha-hydroxyprogesterone
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17beta-hsds
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dhea-s
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virilization
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tanner
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11-deoxycortisol
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allopregnanolone
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sulfatases
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kallmann
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medicine
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analysis
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pregs
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incidentalomas
- 3.1.6.2
- women
- testosterone
- androgen
- adrenal
- cortisol
- estradiol
- estrogen
- androstenedione
- sulphate
- globulin
-
polycystic
- ovary
- fsh
-
x-linked
- ovarian
-
postmenopausal
- ichthyosis
- progesterone
- acth
- aromatase
- hyperandrogenism
-
neurosteroids
- hirsutism
-
menstrual
-
hormone-binding
- prolactin
-
luteinizing
- 17-hydroxyprogesterone
-
premenopausal
-
adrenarche
-
sulfotransferase
-
hormone-dependent
- sulfamate
-
endocrinology
-
hyperandrogenemia
-
17beta-hydroxysteroid
-
hypothalamic-pituitary-adrenal
-
pubertal
- pharmacology
- 21-hydroxylase
-
alpha-hydroxyprogesterone
- 17beta-hsds
-
dhea-s
-
virilization
-
tanner
- 11-deoxycortisol
- allopregnanolone
-
sulfatases
-
kallmann
- medicine
- analysis
-
pregs
-
incidentalomas
Reaction
Synonyms
3-beta-hydroxysteroid sulfate sulfatase, arylsufatase, arylsulfatase C, ASC, AtsA, cholesterol sulfate sulfohydrolase, CHS-ase, dehydroepiandrosterone sulfatase, dehydroepiandrosterone sulfate sulfatase, DHEAS, E1-STS, ES, estrone sulfatase, More, neurosteroid sulfatase, NSS, oestrone sulfatase, phenolic steroid sulfatase, pregnenolone sulfatase, steroid 3-sulfatase, steroid sulfatase, steroid sulfate sulfohydrolase, steroid sulphatase, sterol sulfatase, sterolsulfate sulfohydrolase, Steryl-sulfate sulfohydrolase, STS, sulfatase, sterol
ECTree
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Engineering
Engineering on EC 3.1.6.2 - steryl-sulfatase
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DELTA1-21
lacks 21 N-terminal amino acids, that encode the signal peptide, reduced STS activity
N259Q
point mutation in asparagine 259 glycosylation site, reduced STS activity
N333Q
point mutation in other potential glycosylation site asparagine 333, no reduced STS activity
N459Q
point mutation in other potential glycosylation site asparagine 459, no reduced STS activity
N47Q
point mutation in asparagine 47 glycosylation site, reduced STS activity
N47Q/N259Q
double mutation in asparagine 47 and 259 glycosylation sites, reduced STS activity
N54Q
point mutation in in asparagine 54 non-glycosylation site , no reduced STS activity
Q560P
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no effect of mutation on enzyme synthesis and degradation, dominant negative effect on enzyme activity when coexisting with wild-type enzyme
I156L/K158E/L325F
140fold increase in catalyticefficiency, 3.5 degrees increase in melting temperature at pH 9.0
I156V/L157V/K158I/K330V
140fold increase in catalyticefficiency
R155P/I156V/L325F/K330V
30fold increase in catalyticefficiency, 3.5 degrees increase in melting temperature at pH 9.0
R155P/L157V/K158I/K330V
150fold increase in catalyticefficiency
additional information
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c-terminal truncation mutant using codons 1-559, no effects on protein synthesis and degradation, dominant negative effect on enzyme activity when coexisting with wild-type enzyme
additional information
site directed mutagenisis is introduced using pALTERMax kit
additional information
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site directed mutagenisis is introduced using pALTERMax kit