Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-fluoro-17beta-(3'-trifluoromethylbenzene)sulfonamideestra-1,3,5(10)-trien-3-ol | - |
Homo sapiens | |
4-nitro-17beta-4'-biphenylsulfonamide-1,3,5(10)-estratrien-3-ol | - |
Homo sapiens | |
additional information | design of sulfated steroid inhibitors. The presence of a NO2 or Br at the 2-position of the A-ring results in a decrease in potency compared to their A-ring-unsubstituted counterparts. The presence of a nitro group or fluorine atom at the 4-position of the A-ring results in an increase in potency | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08842 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-549 cell | - |
Homo sapiens | - |
Hs-578T cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-468 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl sulfate + H2O | - |
Homo sapiens | 4-methylumbelliferone + sulfate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1 | - |
pH 7.4, 24°C | Homo sapiens | 4-nitro-17beta-4'-biphenylsulfonamide-1,3,5(10)-estratrien-3-ol | |
2.5 | - |
pH 7.4, 24°C | Homo sapiens | 4-fluoro-17beta-(3'-trifluoromethylbenzene)sulfonamideestra-1,3,5(10)-trien-3-ol |