Activating Compound | Comment | Organism | Structure |
---|---|---|---|
interleukin-1 | in cultured MCF-7 cells | Homo sapiens | |
interleukin-1 | inhibition of cell growth | Homo sapiens | |
Tumor necrosis factor alpha | in cultured MCF-7 cells | Homo sapiens | |
Tumor necrosis factor alpha | inhibition of cell growth | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | increased activity in endocrine-dependent tumors | Homo sapiens |
medicine | higher activity in primary mammary carcinoma | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
breast cyst fluid | - |
Homo sapiens | |
estrone | - |
Homo sapiens | |
Estrone 3-sulfate | - |
Homo sapiens | |
estrone-3-O-(N,N-dimethyl)sulfamate | - |
Homo sapiens | |
estrone-3-O-(N-methyl)sulfamate | - |
Homo sapiens | |
estrone-3-O-methylthiophosphonate | - |
Homo sapiens | |
estrone-3-O-sulfamate | EMATE, most potent, irreversible | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
steroid sulfates + H2O | Homo sapiens | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | steroid + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | MCF-7 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone sulfate + H2O | - |
Homo sapiens | estrone + sulfate | - |
? | |
steroid sulfates + H2O | also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site | Homo sapiens | steroid + sulfate | - |
? |