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Literature summary for 3.1.6.2 extracted from
- Aryl sulfamates are broad spectrum inactivators of sulfatases: effects on sulfatases from various sources (2009), Bioorg. Med. Chem. Lett., 19, 477-480.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate | - |
Haliotis sp. |  |
| 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate | - |
Helix pomatia | |
| 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate | - |
Patella vulgata | |
| 3-nitrophenyl sulfamate | - |
Haliotis sp. | |
| 3-nitrophenyl sulfamate | - |
Helix pomatia | |
| 3-nitrophenyl sulfamate | - |
Patella vulgata | |
| 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate | - |
Haliotis sp. | |
| 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate | - |
Helix pomatia | |
| 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate | - |
Patella vulgata | |
| phosphate | abalone sulfatases is inhibited by phosphate buffer: 15% activity in 5 mM K2HPO4/KH2PO4, pH 7 | Haliotis sp. | |
| phosphate | limpet sulfatase is inhibited by phosphate buffer: 4% activity in 5 mM K2HPO4/KH2PO4, pH 7 | Patella vulgata | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.03 | - |
4-nitrophenyl sulfate | - |
Helix pomatia | |
| 10 | - |
4-nitrophenyl sulfate | - |
Patella vulgata | |
| 10.2 | - |
4-nitrophenyl sulfate | - |
Haliotis sp. | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haliotis sp. | - |
abalone entrails | - |
| Helix pomatia | - |
- |
- |
| Patella vulgata | - |
keyhole limpet | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl sulfate + H2O | - |
Helix pomatia | 4-nitrophenol + sulfate | - |
? | |
| 4-nitrophenyl sulfate + H2O | - |
Patella vulgata | 4-nitrophenol + sulfate | - |
? | |
| 4-nitrophenyl sulfate + H2O | - |
Haliotis sp. | 4-nitrophenol + sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| estrone sulfatase | - |
Helix pomatia |
| estrone sulfatase | - |
Patella vulgata |
| estrone sulfatase | - |
Haliotis sp. |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.035 | - |
3-nitrophenyl sulfamate | - |
Helix pomatia | |
| 0.98 | - |
3-nitrophenyl sulfamate | - |
Patella vulgata | |
| 1.6 | - |
3-nitrophenyl sulfamate | - |
Haliotis sp. | |
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Release 2023.1 (January 2023)
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