Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Insulin | human recombinant insulin, 30% activation at 10 ng/ml | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | blocking of dehydroepiandrosterone sulfate sulfatase activity could be prove to be clinically important in oestrogen-dependent tumors in pre-menopausal women | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
estrone-3-O-sulfamate | potent inhibitor, dose-dependent, maximum inhibition between 100 and 1000 nM | Homo sapiens | |
human pituitary luteinizing hormone | human pituitary LH, reduces activity to 85% of baseline at 5 ng/ml, dose-dependent | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | Homo sapiens | oestrogen biosynthesis | dehydroepiandrosterone + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
granulosa cell | luteinized, follicle | Homo sapiens | - |
ovarian follicle | luteinized granulosa cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone sulfate + H2O | - |
Homo sapiens | dehydroepiandrosterone + sulfate | - |
? | |
dehydroepiandrosterone sulfate + H2O | oestrogen biosynthesis | Homo sapiens | dehydroepiandrosterone + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid sulphatase | - |
Homo sapiens |