1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, lactate dehydrogenase, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, mLDH, More, muscle LDH, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.27 - L-lactate dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02 - 0.059
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
0.00008
(benzylamino)(oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.16 - 0.2
(heptylamino)(oxo)acetic acid
0.047 - 0.133
(hexylamino)(oxo)acetic acid
0.088 - 0.2
(nonylamino)(oxo)acetic acid
0.0083 - 0.179
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.00175 - 0.0114
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
0.0031 - 0.187
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
21
2,6-naphthalene disulfonic acid
Plasmodium falciparum
-
IC50: 21 mM
5.1
2,6-naphthalenedicarboxalic acid
Plasmodium falciparum
-
IC50: 5.1 mM
1.7
3,5-dihydroxy 2-naphthoic acid
Plasmodium falciparum
-
IC50: 1.7 mM
1.7 - 150
3,5-dihydroxynaphthalene-2-carboxylic acid
2.4
3,7-dihydroxy naphthalene-2-carboxylic acid
Plasmodium falciparum
-
IC50: 2.4 mM
2.4 - 5
3,7-dihydroxynaphthalene-2-carboxylic acid
0.0011
3-hydroxy-1,2-oxazole-4-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.31 - 5.9
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
0.00065
4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.00014
4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.016
4-hydroxy-1,2-oxazole-3-carboxylic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
4.6 - 6.6
6,6'-disulfanediyldipyridine-3-carboxylic acid
6.6
6,6'-Dithiodinicotinic acid
Plasmodium falciparum
-
IC50: 6.6 mM
0.191 - 0.225
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.52 - 1.1
8-(phenylamino)naphthalene-1-sulfonic acid
0.0873 - 0.232
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.52
8-anilino-1-naphthalene sulfonic acid
Plasmodium falciparum
-
IC50: 0.52 mM
0.0944 - 0.116
amino(oxo)acetic acid
0.00005
cardiolipin
Sus scrofa
-
IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5
5.5
Chloroquine
Plasmodium falciparum
-
IC50: 5.5 mM
4.6
methylmalonate
Rattus norvegicus
-
IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver)
1.4 - 5.11
naphthalene-2,6-dicarboxylic acid
9.8 - 21
naphthalene-2,6-disulfonic acid
0.15 - 0.2
oxo(pentadecylamino)acetic acid
0.0001
oxo[(2-phenylethyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.000035
oxo[(3-phenylpropyl)amino]acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.041 - 0.088
oxo[(4-phenylbutyl)amino]acetic acid
0.0188 - 0.2
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
0.146 - 0.2
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
0.0013
phosphatidylserine
Sus scrofa
-
IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5
0.158 - 0.2
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
0.014 - 0.025
[(2-methoxyethyl)amino](oxo)acetic acid
0.035 - 0.09
[(3,3-diphenylpropyl)amino](oxo)acetic acid
0.031 - 0.043
[(3-methoxypropyl)amino](oxo)acetic acid
0.157 - 0.2
[(3-methylbutyl)amino](oxo)acetic acid
0.0979 - 0.107
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
0.00007
[(4-chlorobenzyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.00009
[(4-methylbenzyl)amino](oxo)acetic acid
Plasmodium falciparum
-
pH not specified in the publication, temperature not specified in the publication
0.186 - 0.2
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
0.043 - 0.2
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
0.168 - 0.2
[benzyl(methyl)amino](oxo)acetic acid
0.043 - 0.2
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
0.046 - 0.169
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
0.059 - 0.101
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
0.032 - 0.2
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
0.051 - 0.2
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid