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Literature summary for 1.1.1.27 extracted from

  • Terlecki, G.; Czapinska, E.; Rogozik, K.; Lisowski, M.; Gutowicz, J.
    Investigation of the interaction of pig muscle lactate dehydrogenase with acidic phospholipids at low pH (2006), Biochim. Biophys. Acta, 1758, 133-144.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cardiolipin IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa
phosphatidylserine IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + NADH + H+
-
Sus scrofa (S)-lactate + NAD+
-
?

Cofactor

Cofactor Comment Organism Structure
NADH
-
Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
IC50: 0.00005 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa cardiolipin
0.0013
-
IC50: 0.0013 mM, interaction with acidic phospholipids is most efficient at pH values below pH 6.5 Sus scrofa phosphatidylserine