1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, L-nLDH, lactate dehydrogenase, lactate dehydrogenase 5, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, ldhL, mLDH, More, muscle LDH, NAD-dependent lactate dehydrogenase, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, SMU.1115, SMU_1115, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

Turnover Number

Turnover Number on EC 1.1.1.27 - L-lactate dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000045 - 65
(S)-lactate
80
2-oxobutyrate
-
pH 7.5
0.64
2-oxovalerate
-
pH 7.5
1.4 - 333.3
3-acetylpyridine adenine dinucleotide
0.33
4-methyl-2-oxopentanoate
-
wild-type enzyme
0.000248
APAD+
-
pH 5.5, 25C, recombinant enzyme
0.00386
APADH
-
pH 5.5, 25C, recombinant enzyme
269
Bromopyruvate
-
-
0.7 - 6.2
epsilon-NAD+
98
Fluoropyruvate
-
-
40
L-lactate
-
pH 7.5
0.000055 - 65
NAD+
0.00208 - 2330
NADH
1.1 - 18.8
nicotinamide hypoxanthine dinucleotide
39.5
phenylpyruvate
-
wild-type enzyme
0.00209 - 1800
pyruvate
176
pyruvate ethyl ester
-
-
227
pyruvate methyl ester
-
-
additional information
additional information
-