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Literature summary for 1.1.1.27 extracted from

  • Granchi, C.; Bertini, S.; Macchia, M.; Minutolo, F.
    Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials (2010), Curr. Med. Chem., 17, 672-697.
    View publication on PubMed

Application

Application Comment Organism
drug development the parasite enzyme is a potential target for antimalarial drugs Plasmodium falciparum
medicine the enzyme is a target for treatment of cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the single gene encoding the enzyme is located on chromosome 13 Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
additional information knockdown of LDH-A by shRNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
-
Bos taurus
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
-
Homo sapiens
(abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
-
Plasmodium falciparum
(benzylamino)(oxo)acetic acid
-
Bos taurus
(benzylamino)(oxo)acetic acid
-
Homo sapiens
(benzylamino)(oxo)acetic acid
-
Plasmodium falciparum
(heptylamino)(oxo)acetic acid
-
Bos taurus
(heptylamino)(oxo)acetic acid
-
Homo sapiens
(heptylamino)(oxo)acetic acid
-
Plasmodium falciparum
(hexylamino)(oxo)acetic acid
-
Bos taurus
(hexylamino)(oxo)acetic acid
-
Homo sapiens
(hexylamino)(oxo)acetic acid
-
Plasmodium falciparum
(nonylamino)(oxo)acetic acid
-
Bos taurus
(nonylamino)(oxo)acetic acid
-
Homo sapiens
(nonylamino)(oxo)acetic acid
-
Plasmodium falciparum
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Bos taurus
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Homo sapiens
([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Plasmodium falciparum
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
-
Bos taurus
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
-
Homo sapiens
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
-
Plasmodium falciparum
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Bos taurus
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Homo sapiens
([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
-
Plasmodium falciparum
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone
-
Homo sapiens
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone
-
Plasmodium falciparum
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
3,5-dihydroxynaphthalene-2-carboxylic acid
-
Homo sapiens
3,5-dihydroxynaphthalene-2-carboxylic acid
-
Plasmodium falciparum
3,7-dihydroxynaphthalene-2-carboxylic acid
-
Homo sapiens
3,7-dihydroxynaphthalene-2-carboxylic acid
-
Plasmodium falciparum
3-(3-nitro-4-pyridyl)pyruvate
-
Homo sapiens
3-(3-nitropyridin-4-yl)-2-oxopropanoic acid
-
Plasmodium falciparum
3-hydroxy-1,2-oxazole-4-carboxylic acid
-
Plasmodium falciparum
3-hydroxy-1-oxaspiro[4.5]dec-3-en-2-one
-
Plasmodium falciparum
3-hydroxy-2-oxo-1-oxaspiro[4,5]-dec-3-ene
-
Homo sapiens
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
-
Homo sapiens
4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
-
Plasmodium falciparum
4-(ethylcarbamoyl)benzoic acid
-
Homo sapiens
4-(ethylcarbamoyl)benzoic acid
-
Plasmodium falciparum
4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
-
Plasmodium falciparum
4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid
-
Plasmodium falciparum
4-hydroxy-1,2-oxazole-3-carboxylic acid
-
Plasmodium falciparum
6,6'-disulfanediyldipyridine-3-carboxylic acid
-
Homo sapiens
6,6'-disulfanediyldipyridine-3-carboxylic acid
-
Plasmodium falciparum
7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid
-
Homo sapiens
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Homo sapiens
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid
-
Plasmodium falciparum
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid
-
Homo sapiens
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid
-
Plasmodium falciparum
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid
-
Homo sapiens
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid
-
Plasmodium falciparum
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate
-
Homo sapiens
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate
-
Plasmodium falciparum
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate
-
Homo sapiens
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate
-
Plasmodium falciparum
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate
-
Homo sapiens
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate
-
Plasmodium falciparum
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate
-
Homo sapiens
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate
-
Plasmodium falciparum
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Bos taurus
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Homo sapiens
8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Plasmodium falciparum
8-(phenylamino)naphthalene-1-sulfonic acid
-
Homo sapiens
8-(phenylamino)naphthalene-1-sulfonic acid
-
Plasmodium falciparum
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Bos taurus
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Homo sapiens
8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
-
Plasmodium falciparum
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one
-
Homo sapiens
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one
-
Plasmodium falciparum
amino(oxo)acetic acid
-
Bos taurus
amino(oxo)acetic acid
-
Homo sapiens
amino(oxo)acetic acid
-
Plasmodium falciparum
bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')copper
-
Homo sapiens
bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')copper
-
Plasmodium falciparum
bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')zinc
-
Homo sapiens
bis(acetatato-kO)(biphenyl-2,2'-diyl-k2C2,C2')zinc
-
Plasmodium falciparum
ethyl 3-(3-cyano-4-pyridyl)pyruvate
-
Homo sapiens
ethyl 3-(3-cyanopyridin-4-yl)-2-oxopropanoate
-
Plasmodium falciparum
gossypol
-
Homo sapiens
gossypol a polyphenolic binaphthyl disesquiterpene from Gossypium sp. Plasmodium falciparum
naphthalene-2,6-dicarboxylic acid
-
Homo sapiens
naphthalene-2,6-dicarboxylic acid
-
Plasmodium falciparum
naphthalene-2,6-disulfonic acid
-
Homo sapiens
naphthalene-2,6-disulfonic acid
-
Plasmodium falciparum
oxo(pentadecylamino)acetic acid
-
Bos taurus
oxo(pentadecylamino)acetic acid
-
Homo sapiens
oxo(pentadecylamino)acetic acid
-
Plasmodium falciparum
oxo(phenylamino)acetic acid
-
Bos taurus
oxo(phenylamino)acetic acid
-
Homo sapiens
oxo(phenylamino)acetic acid
-
Plasmodium falciparum
oxo[(2-phenylethyl)amino]acetic acid
-
Bos taurus
oxo[(2-phenylethyl)amino]acetic acid
-
Homo sapiens
oxo[(2-phenylethyl)amino]acetic acid
-
Plasmodium falciparum
oxo[(2-phenylpropyl)amino]acetic acid
-
Bos taurus
oxo[(2-phenylpropyl)amino]acetic acid
-
Homo sapiens
oxo[(2-phenylpropyl)amino]acetic acid
-
Plasmodium falciparum
oxo[(3-phenylpropyl)amino]acetic acid
-
Bos taurus
oxo[(3-phenylpropyl)amino]acetic acid
-
Homo sapiens
oxo[(3-phenylpropyl)amino]acetic acid
-
Plasmodium falciparum
oxo[(4-phenylbutan-2-yl)amino]acetic acid
-
Bos taurus
oxo[(4-phenylbutan-2-yl)amino]acetic acid
-
Homo sapiens
oxo[(4-phenylbutan-2-yl)amino]acetic acid
-
Plasmodium falciparum
oxo[(4-phenylbutyl)amino]acetic acid
-
Bos taurus
oxo[(4-phenylbutyl)amino]acetic acid
-
Homo sapiens
oxo[(4-phenylbutyl)amino]acetic acid
-
Plasmodium falciparum
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
-
Bos taurus
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
-
Homo sapiens
oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
-
Plasmodium falciparum
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
-
Bos taurus
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
-
Homo sapiens
oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
-
Plasmodium falciparum
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
-
Bos taurus
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
-
Homo sapiens
[(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(2-methoxyethyl)amino](oxo)acetic acid
-
Bos taurus
[(2-methoxyethyl)amino](oxo)acetic acid
-
Homo sapiens
[(2-methoxyethyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(3,3-diphenylpropyl)amino](oxo)acetic acid
-
Bos taurus
[(3,3-diphenylpropyl)amino](oxo)acetic acid
-
Homo sapiens
[(3,3-diphenylpropyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(3-methoxypropyl)amino](oxo)acetic acid
-
Bos taurus
[(3-methoxypropyl)amino](oxo)acetic acid
-
Homo sapiens
[(3-methoxypropyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(3-methylbutyl)amino](oxo)acetic acid
-
Bos taurus
[(3-methylbutyl)amino](oxo)acetic acid
-
Homo sapiens
[(3-methylbutyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
-
Bos taurus
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
-
Homo sapiens
[(3-methylphenyl)(phenyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(4-chlorobenzyl)amino](oxo)acetic acid
-
Bos taurus
[(4-chlorobenzyl)amino](oxo)acetic acid
-
Homo sapiens
[(4-chlorobenzyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(4-methylbenzyl)amino](oxo)acetic acid
-
Bos taurus
[(4-methylbenzyl)amino](oxo)acetic acid
-
Homo sapiens
[(4-methylbenzyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
-
Bos taurus
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
-
Homo sapiens
[(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
-
Bos taurus
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
-
Homo sapiens
[(naphthalen-1-ylmethyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[benzyl(methyl)amino](oxo)acetic acid
-
Bos taurus
[benzyl(methyl)amino](oxo)acetic acid
-
Homo sapiens
[benzyl(methyl)amino](oxo)acetic acid
-
Plasmodium falciparum
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
-
Bos taurus
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
-
Homo sapiens
[bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
-
Plasmodium falciparum
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
-
Bos taurus
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
-
Homo sapiens
[bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
-
Plasmodium falciparum
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
-
Bos taurus
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
-
Homo sapiens
[bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
-
Plasmodium falciparum
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
-
Bos taurus
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
-
Homo sapiens
[bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
-
Plasmodium falciparum
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
-
Bos taurus
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
-
Homo sapiens
[[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lactate + NAD+ Homo sapiens
-
pyruvate + NADH + H+
-
r
L-lactate + NAD+ Bos taurus
-
pyruvate + NADH + H+
-
r
L-lactate + NAD+ Plasmodium falciparum
-
pyruvate + NADH + H+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
several isozymes, overview
-
Plasmodium falciparum
-
several isozymes
-
Plasmodium malariae
-
several isozymes
-
Plasmodium ovale
-
several isozymes
-
Plasmodium vivax
-
several isozymes
-

Reaction

Reaction Comment Organism Reaction ID
(S)-lactate + NAD+ = pyruvate + NADH + H+ the enzyme-NADH-pyruvate ternery complex undergoes a rate-limiting conformational change, in which the substrate loop closes to form a desolvated ternary complex in order to bring the catalytic residue Arg109 into the active site, the catalytic residues Arg109, Asp168, and His195 are highly conserved, catalyic mechanism, detailed overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-
liver
-
Homo sapiens
-
additional information homo- and heterotetrameric isozymes with tissue-specific expression Homo sapiens
-
skeletal muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lactate + NAD+
-
Homo sapiens pyruvate + NADH + H+
-
r
L-lactate + NAD+
-
Bos taurus pyruvate + NADH + H+
-
r
L-lactate + NAD+
-
Plasmodium falciparum pyruvate + NADH + H+
-
r
L-lactate + NAD+ amino acid residues involved in substrate and cofactor binding are Arg109, Asp168, Arg171, and His195 Plasmodium falciparum pyruvate + NADH + H+
-
r

Subunits

Subunits Comment Organism
More Rossmann fold topology, structure comparison to the enzyme from Homo sapiens, PDB IDs 1i10 and 1ldg, differences occur mainly in the N-terminus, overview Plasmodium falciparum
More structure comparison of LDH-M and LDH-H subunit isoforms, the homotetramers have essentially the same tertiary structure, while the hybrid tetramers show different structures, overview. Rossmann fold topology, structure comparison to the enzyme from Plasmodium falciparum, PDB IDs 1i10 and 1ldg, Ser163 is a highly conserved residue amongst human hLDH isozymes, corresponds to Leu163 in PfLDH, differences occur mainly in the N-terminus, overview Homo sapiens
tetramer homo- and heterotetrameric isozymes with tissue-specific expression Homo sapiens

Synonyms

Synonyms Comment Organism
lactate dehydrogenase
-
Homo sapiens
lactate dehydrogenase
-
Bos taurus
lactate dehydrogenase
-
Plasmodium falciparum
lactate dehydrogenase
-
Plasmodium vivax
lactate dehydrogenase
-
Plasmodium malariae
lactate dehydrogenase
-
Plasmodium ovale
LDH
-
Homo sapiens
LDH-A
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus
NAD+
-
Plasmodium falciparum
NAD+ binding structure, overview Homo sapiens
NADH
-
Homo sapiens
NADH
-
Bos taurus
NADH
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00003
-
2,3-dihydroxy-6-methyl-7-(4-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.00005
-
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0001
-
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0001
-
2,3-dihydroxy-6,7-dimethyl-4-propylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0002
-
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0002
-
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0002
-
2,3-dihydroxy-6-methyl-7-(3-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0003
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0003
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl pentanoate pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0003
-
7-benzyl-2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0004
-
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0005
-
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0006
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0006
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl butanoate pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0006
-
8-[8-acetyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-yl)naphthalen-2-yl]-3,4-dihydroxy-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-2-one LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0007
-
gossypol pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0007
-
7-benzyl-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0008
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0008
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl acetate pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.001
-
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.001
-
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.001
-
7-(4-chlorobenzyl)-2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0011
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0011
-
8'-acetyl-8-cyano-1',6,6',7,7'-pentahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalen-1-yl propanoate pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0012
-
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.0013
-
8'-acetyl-1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-di(propan-2-yl)-2,2'-binaphthalene-8-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0014
-
gossypol LDH-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0019
-
gossypol LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.002
-
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.002
-
2,3-dihydroxy-6,7-dimethyl-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0025
-
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.003
-
2,3-dihydroxy-6-methyl-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.003
-
2,3-dihydroxy-6-methyl-7-(2-methylbenzyl)-4-(propan-2-yl)naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.004
-
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.0042
-
gossypol LDH-C, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.006
-
2,3-dihydroxy-6-methyl-4-propylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.008
-
7-benzyl-2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.013
-
2,3-dihydroxy-4,6,7-trimethylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.013
-
2,3-dihydroxy-6-methyl-4-(propan-2-yl)-7-[4-(trifluoromethyl)benzyl]naphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.016
-
1-[7-[3,4-dihydroxy-2-imino-7-methyl-5-(propan-2-yl)-2H-naphtho[1,8-bc]furan-8-yl]-2,3,8-trihydroxy-6-methyl-4-(propan-2-yl)naphthalen-1-yl]ethanone pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.022
-
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum
0.034
-
2,3-dihydroxy-4,6-dimethylnaphthalene-1-carboxylic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.4
-
(benzylamino)(oxo)acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.8
-
oxo[(4-phenylbutan-2-yl)amino]acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.9
-
oxo[(3-phenylpropyl)amino]acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
1
-
[(4-chlorobenzyl)amino](oxo)acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
2
-
oxo[(4-phenylbutyl)amino]acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
2
-
[(4-methylbenzyl)amino](oxo)acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
7
-
oxo[(2-phenylethyl)amino]acetic acid LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
10
-
oxo(phenylamino)acetic acid above, LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens
10
-
oxo[(2-phenylpropyl)amino]acetic acid above, LDH-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000035
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo[(3-phenylpropyl)amino]acetic acid
0.00007
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(4-chlorobenzyl)amino](oxo)acetic acid
0.00008
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum (benzylamino)(oxo)acetic acid
0.00009
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(4-methylbenzyl)amino](oxo)acetic acid
0.0001
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo[(2-phenylethyl)amino]acetic acid
0.00014
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid
0.00065
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid
0.0011
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 3-hydroxy-1,2-oxazole-4-carboxylic acid
0.00175
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
0.0031
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.0083
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.0114
-
pH not specified in the publication, temperature not specified in the publication Bos taurus ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]-2-methoxyphenyl]amino)(oxo)acetic acid
0.014
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(2-methoxyethyl)amino](oxo)acetic acid
0.016
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 4-hydroxy-1,2-oxazole-3-carboxylic acid
0.0188
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
0.02
-
pH not specified in the publication, temperature not specified in the publication Bos taurus (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
0.025
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(2-methoxyethyl)amino](oxo)acetic acid
0.031
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(3-methoxypropyl)amino](oxo)acetic acid
0.032
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
0.035
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(3,3-diphenylpropyl)amino](oxo)acetic acid
0.041
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo[(4-phenylbutyl)amino]acetic acid
0.043
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(naphthalen-1-ylmethyl)amino](oxo)acetic acid
0.043
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(3-methoxypropyl)amino](oxo)acetic acid
0.043
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
0.046
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
0.047
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum (hexylamino)(oxo)acetic acid
0.051
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
0.059
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum (abieta-8,11,13-trien-18-ylamino)(oxo)acetic acid
0.059
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
0.0873
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.088
-
pH not specified in the publication, temperature not specified in the publication Bos taurus oxo[(4-phenylbutyl)amino]acetic acid
0.088
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum (nonylamino)(oxo)acetic acid
0.09
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(3,3-diphenylpropyl)amino](oxo)acetic acid
0.0944
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum amino(oxo)acetic acid
0.0979
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(3-methylphenyl)(phenyl)amino](oxo)acetic acid
0.101
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [bis(4-benzylpiperidin-1-yl)amino](oxo)acetic acid
0.107
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(3-methylphenyl)(phenyl)amino](oxo)acetic acid
0.116
-
pH not specified in the publication, temperature not specified in the publication Bos taurus amino(oxo)acetic acid
0.133
-
pH not specified in the publication, temperature not specified in the publication Bos taurus (hexylamino)(oxo)acetic acid
0.146
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
0.15
-
pH not specified in the publication, temperature not specified in the publication Bos taurus oxo(pentadecylamino)acetic acid
0.157
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(3-methylbutyl)amino](oxo)acetic acid
0.158
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
0.16
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum (heptylamino)(oxo)acetic acid
0.168
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [benzyl(methyl)amino](oxo)acetic acid
0.169
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [bis(4-benzylpiperazin-1-yl)amino](oxo)acetic acid
0.179
-
pH not specified in the publication, temperature not specified in the publication Bos taurus ([2-cyano-4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.186
-
pH not specified in the publication, temperature not specified in the publication Bos taurus [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
0.187
-
pH not specified in the publication, temperature not specified in the publication Bos taurus ([4-[2-([5-hydroxy-2-[(4-methoxybenzyl)carbamoyl]-4-oxo-4H-chromen-8-yl]oxy)ethyl]phenyl]amino)(oxo)acetic acid
0.191
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(2-ethylphenyl)(phenyl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus (heptylamino)(oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum oxo(pentadecylamino)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [(furan-2-ylmethyl)(methyl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus [(naphthalen-1-ylmethyl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus (nonylamino)(oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [bis(4-phenylpiperazin-1-yl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [benzyl(methyl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum [bis(2-methylpiperidin-1-yl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus [(3-methylbutyl)amino](oxo)acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus oxo[(tetrahydrofuran-2-ylmethyl)amino]acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus oxo[[1-(5,6,7,8-tetrahydronaphthalen-1-yl)ethyl]amino]acetic acid
0.2
-
above, pH not specified in the publication, temperature not specified in the publication Bos taurus [[2-(4-bromophenyl)ethyl]amino](oxo)acetic acid
0.225
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 8-(2-[4-[(carboxycarbonyl)amino]-3-methoxyphenyl]ethoxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.232
-
pH not specified in the publication, temperature not specified in the publication Bos taurus 8-([4-[(carboxycarbonyl)amino]-3-methoxybenzyl]oxy)-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid
0.31
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
0.52
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 8-(phenylamino)naphthalene-1-sulfonic acid
1.1
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 8-(phenylamino)naphthalene-1-sulfonic acid
1.4
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens naphthalene-2,6-dicarboxylic acid
1.7
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 3,5-dihydroxynaphthalene-2-carboxylic acid
2.4
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 3,7-dihydroxynaphthalene-2-carboxylic acid
4.6
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 6,6'-disulfanediyldipyridine-3-carboxylic acid
5
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,7-dihydroxynaphthalene-2-carboxylic acid
5.11
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum naphthalene-2,6-dicarboxylic acid
5.9
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4,7-dibromo-3-hydroxynaphthalene-2-carboxylic acid
6.6
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum 6,6'-disulfanediyldipyridine-3-carboxylic acid
9.8
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens naphthalene-2,6-disulfonic acid
21
-
pH not specified in the publication, temperature not specified in the publication Plasmodium falciparum naphthalene-2,6-disulfonic acid
150
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3,5-dihydroxynaphthalene-2-carboxylic acid

General Information

General Information Comment Organism
metabolism LDH plays a central role in several metabolic pathways, e.g. in energy production in glycolysis, in gluconeogenesis. Glycolytic process, overview Homo sapiens
additional information the enzyme is involved in development of cancer, especially of hypoxic cancer cells, since the cancer cells relay on LDH-A for the energy supply. The glycolytic phenotype is responsible for the tumorigenicity of hypoxic cells Homo sapiens
physiological function LDH-A deficiency causes myoglobinuria Homo sapiens
physiological function the parasite's ATP production is almost completely dependent on the glucose metabolism and the glycolytic pathway, that is absent in normal human host cells, overview. PfLDH plays the essential role in NAD+ regenration needed for the continuity of the glycolytic cycle Plasmodium falciparum