Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.27 extracted from

  • Saad, L.O.; Mirandola, S.R.; Maciel, E.N.; Castilho, R.F.
    Lactate dehydrogenase activity is inhibited by methylmalonate in vitro (2006), Neurochem. Res., 31, 541-548.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-nitropropionate
-
Rattus norvegicus
methylmalonate
-
Bos taurus
methylmalonate IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver) Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.79
-
(S)-lactate
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
brain
-
Bos taurus
-
heart
-
Bos taurus
-
liver
-
Rattus norvegicus
-
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-lactate + NAD+
-
Rattus norvegicus pyruvate + NADH + H+
-
?
(S)-lactate + NAD+
-
Bos taurus pyruvate + NADH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NAD+
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.02
-
methylmalonate enzyme from brain Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.6
-
IC50: 4.6 mM (enzyme from brain), 4.6 mM (enzyme from liver) Rattus norvegicus methylmalonate