1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, lactate dehydrogenase, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, mLDH, More, muscle LDH, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

Temperature Stability

Temperature Stability on EC 1.1.1.27 - L-lactate dehydrogenase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 35
46
-
1 h, 25°C, 50% loss of activity, mutant enzyme with a deletion of 10 N-terminal amino acids
48
-
30 min, stable up to
51
-
20 min, about 75% loss of activity, isoenzyme A4
53
-
20 min, complete loss of activity of isoenzyme A4, about 40% loss of activity of isoenzyme A2B2
61
-
20 min, 50% loss of activity, allozyme LDH-Ba/Bb
63
-
20 min, 50% loss of activity, allozyme LDH-Bb4
66
-
20 min, about 35% loss of activity of isoenzyme B4
71.5
-
20 min, 50% loss of activity
73.5
-
30 min, 50% loss of activity
74
-
30 min, stable up to
75
-
30 min, 50% loss of activity
80
purified recombinant enzyme, half-life is 1.5 h
additional information