1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, lactate dehydrogenase, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, mLDH, More, muscle LDH, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

Source Tissue

Source Tissue on EC 1.1.1.27 - L-lactate dehydrogenase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
the level of L-lactate dehydrogenase B are specifically increased in non-small cell lung cancer
Manually annotated by BRENDA team
lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Manually annotated by BRENDA team
-
embryonic membrane of oncosphere
Manually annotated by BRENDA team
-
cerebellar
Manually annotated by BRENDA team
lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Manually annotated by BRENDA team
-
fat-free milk, or 2% fat milk
Manually annotated by BRENDA team
-
primary non-small cell lung cancer cell line
Manually annotated by BRENDA team
-
brain metastatic subline of NCI-H226. L-lactate dehydrogenase B is significantly up-regulated in the conditional medium of NCI-H226Br cells
Manually annotated by BRENDA team
-
activities of both H- and M-isoforms of LDH are high but neurons show a dominance of H-isoform activity
Manually annotated by BRENDA team
lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Manually annotated by BRENDA team
-
patients with tubercular pyothorax show highest levels in LDH-5 followed by LDH-4, LDH-3, LDH-2 and LDH-1
Manually annotated by BRENDA team
lactate dehydrogenase-B is silenced by promoter hypermethylation in human prostate cancer
Manually annotated by BRENDA team
-
patients with tubercular pyothorax show highest levels in LDH-5 followed by LDH-4, LDH-2, LDH-3 and LDH-1. In LDH-5 and LDH-4 nearly 4- and 5folds increase in patients
Manually annotated by BRENDA team
additional information