1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, lactate dehydrogenase, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, mLDH, More, muscle LDH, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.27 - L-lactate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.11
wild-type, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
0.58
mutant R157L, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
0.63
mutant R157L, pH 7.3, 55C
0.714
-
isoenzyme I
1.27
mutant R157L, lacking alcohol/aldehyde dehydrogenase gene AdhE, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
1.44
mutant R157L, lacking alcohol/aldehyde dehydrogenase gene AdhE, pH 7.3, 55C
1.87
-
isoenzyme II
5.1
-
single pyruvate decarboxylase 1 mutant strain T157
11.5
-
pyruvate decarboxylase 1/alcohol dehydrogenase 1 mutant strain AF297C
30
-
commercial preparation
53
Agama stellio stellio
-
-
80
-
isoenzyme X
80.27
Molinema dessetae
-
-
203.3
-
purified native enzyme, substrate pyruvate
215
-
reduction of pyruvate
216
-
reduction of pyruvate
253
reduction of pyruvate
450
reduction of pyruvate
456
-
purified protein with pyruvate as substrate
458.5
-
-
2119
-
recombinant enzyme
additional information