1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, L-nLDH, lactate dehydrogenase, lactate dehydrogenase 5, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, ldhL, mLDH, More, muscle LDH, NAD-dependent lactate dehydrogenase, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, SMU.1115, SMU_1115, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.27 - L-lactate dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.11
wild-type, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
0.58
mutant R157L, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
0.63
mutant R157L, pH 7.3, 55C
0.714
-
isoenzyme I
1.27
mutant R157L, lacking alcohol/aldehyde dehydrogenase gene AdhE, pH 7.3, 55C, presence of fructose-1,6-bisphosphate
1.44
mutant R157L, lacking alcohol/aldehyde dehydrogenase gene AdhE, pH 7.3, 55C
1.87
-
isoenzyme II
5.1
-
single pyruvate decarboxylase 1 mutant strain T157
7.35
-
purified native aerobic control enzyme, pH 7.2, 25C, pyruvate reduction
9.3 - 12.2
-
native enzyme in strain MG1363 at different growth phases and conditions, pH 7.0, 30C
11.5
-
pyruvate decarboxylase 1/alcohol dehydrogenase 1 mutant strain AF297C
15.8
-
purified native anoxic enzyme, pH 7.2, 25C, pyruvate reduction
30
-
commercial preparation
52
NADH oxidation, pH 8.0, temperature not specified in the publication, healthy breast tissue
53
Agama stellio stellio
-
-
80
-
isoenzyme X
80.27
Molinema dessetae
-
-
203.3
-
purified native enzyme, substrate pyruvate
215
-
reduction of pyruvate
216
-
reduction of pyruvate
253
-
reduction of pyruvate
351
purified recombinant enzyme, pH 11.5, 55C, lactate oxidation
450
reduction of pyruvate
456
-
purified protein with pyruvate as substrate
458.5
-
-
1747
pyruvate reduction, pH 8.0, temperature not specified in the publication, healthy breast tissue
2119
-
recombinant enzyme
2323
purified recombinant enzyme, pH 6.5, 55C, pyruvate reduction
2788
NADH oxidation, pH 8.0, temperature not specified in the publication, breast cancer tissue
4034
pyruvate reduction, pH 8.0, temperature not specified in the publication, breast cancer tissue
additional information