Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.27 extracted from

  • Conners, R.; Schambach, F.; Read, J.; Cameron, A.; Sessions, R.B.; Vivas, L.; Easton, A.; Croft, S.L.; Brady, R.L.
    Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase (2005), Mol. Biochem. Parasitol., 142, 137-148.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystals the apo-form of PfLDH are ontained by hanging-drop method with 2-methyl-2,4-pentanediol as precipitant, crystallization of enzyme:naphthoic acid complexes with 2,6-naphthalenedicarboxalic acid, 2,6-naphthalene disulfonic acid or 3,7-dihydroxy naphthalene-2-carboxylic acid and 3,7-dihydroxy naphthalene-2-carboxylic acid plus NAD+ Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
1,6-dibromo-2-hydroxynaphthalene 3-carboxylic acid 0.31 mM Plasmodium falciparum
2,6-naphthalene disulfonic acid IC50: 21 mM Plasmodium falciparum
2,6-naphthalenedicarboxalic acid IC50: 5.1 mM Plasmodium falciparum
3,5-dihydroxy 2-naphthoic acid IC50: 1.7 mM Plasmodium falciparum
3,7-dihydroxy naphthalene-2-carboxylic acid IC50: 2.4 mM Plasmodium falciparum
6,6'-Dithiodinicotinic acid IC50: 6.6 mM Plasmodium falciparum
8-anilino-1-naphthalene sulfonic acid IC50: 0.52 mM Plasmodium falciparum
Chloroquine IC50: 5.5 mM Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.52
-
IC50: 0.52 mM Plasmodium falciparum 8-anilino-1-naphthalene sulfonic acid
1.7
-
IC50: 1.7 mM Plasmodium falciparum 3,5-dihydroxy 2-naphthoic acid
2.4
-
IC50: 2.4 mM Plasmodium falciparum 3,7-dihydroxy naphthalene-2-carboxylic acid
5.1
-
IC50: 5.1 mM Plasmodium falciparum 2,6-naphthalenedicarboxalic acid
5.5
-
IC50: 5.5 mM Plasmodium falciparum Chloroquine
6.6
-
IC50: 6.6 mM Plasmodium falciparum 6,6'-Dithiodinicotinic acid
21
-
IC50: 21 mM Plasmodium falciparum 2,6-naphthalene disulfonic acid