Crystallization (Comment) | Organism |
---|---|
crystals the apo-form of PfLDH are ontained by hanging-drop method with 2-methyl-2,4-pentanediol as precipitant, crystallization of enzyme:naphthoic acid complexes with 2,6-naphthalenedicarboxalic acid, 2,6-naphthalene disulfonic acid or 3,7-dihydroxy naphthalene-2-carboxylic acid and 3,7-dihydroxy naphthalene-2-carboxylic acid plus NAD+ | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,6-dibromo-2-hydroxynaphthalene 3-carboxylic acid | 0.31 mM | Plasmodium falciparum | |
2,6-naphthalene disulfonic acid | IC50: 21 mM | Plasmodium falciparum | |
2,6-naphthalenedicarboxalic acid | IC50: 5.1 mM | Plasmodium falciparum | |
3,5-dihydroxy 2-naphthoic acid | IC50: 1.7 mM | Plasmodium falciparum | |
3,7-dihydroxy naphthalene-2-carboxylic acid | IC50: 2.4 mM | Plasmodium falciparum | |
6,6'-Dithiodinicotinic acid | IC50: 6.6 mM | Plasmodium falciparum | |
8-anilino-1-naphthalene sulfonic acid | IC50: 0.52 mM | Plasmodium falciparum | |
Chloroquine | IC50: 5.5 mM | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.52 | - |
IC50: 0.52 mM | Plasmodium falciparum | 8-anilino-1-naphthalene sulfonic acid | |
1.7 | - |
IC50: 1.7 mM | Plasmodium falciparum | 3,5-dihydroxy 2-naphthoic acid | |
2.4 | - |
IC50: 2.4 mM | Plasmodium falciparum | 3,7-dihydroxy naphthalene-2-carboxylic acid | |
5.1 | - |
IC50: 5.1 mM | Plasmodium falciparum | 2,6-naphthalenedicarboxalic acid | |
5.5 | - |
IC50: 5.5 mM | Plasmodium falciparum | Chloroquine | |
6.6 | - |
IC50: 6.6 mM | Plasmodium falciparum | 6,6'-Dithiodinicotinic acid | |
21 | - |
IC50: 21 mM | Plasmodium falciparum | 2,6-naphthalene disulfonic acid |