1.1.1.27: L-lactate dehydrogenase

This is an abbreviated version, for detailed information about L-lactate dehydrogenase, go to the full flat file.

Reaction

(S)-lactate
+
NAD+
=
pyruvate
+
NADH
+
H+

Synonyms

A4-LDH, AdhE, anaerobic lactate dehydrogenase, BbLDH, dehydrogenase, lactate, eLDHA, eLDHB, Epsilon crystallin, epsilon-crystallin, H4-L-lactate dehydrogenase, heart LDH, Immunogenic protein p36, L(+)-nLDH, L-(+)-lactate dehydrogenase, L-lactate dehydrogenase B, L-lactic acid dehydrogenase, L-lactic dehydrogenase, L-LDH, lactate dehydrogenase, lactate dehydrogenase A, lactate dehydrogenase B, lactate dehydrogenase NAD-dependent, lactic acid dehydrogenase, lactic dehydrogenase, LctD, LDH, LDH-1, LDH-2, LDH-3, LDH-4, LDH-5, LDH-A, LDH-A4, LDH-m4, LDH1, LDH2, LdhA, LDHB, mLDH, More, muscle LDH, NAD-lactate dehydrogenase, nitric oxideinducible l-lactate dehydrogenase, PfLDH, proteins, specific or class, anoxic stress response, p34, Sa-LDH-1, TeLdhL, Tsac_0416

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.27 L-lactate dehydrogenase

pH Range

pH Range on EC 1.1.1.27 - L-lactate dehydrogenase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3 - 9
-
activity range, the enzyme is inactive below pH 3.0 and above pH 9.0
4.3 - 8
-
no activity below pH 4.3 and above pH 8.0
5 - 7
-
about 55% of maximal activity at pH 5.0 and at pH 7.0
5.2 - 7.2
5.3 - 8
-
pH 5.3: about 50% of maximal activity, pH 8.0: about 60% of maximal activity, reduction of pyruvate
5.4 - 10.8
Agama stellio stellio
-
pH 5.4: about 60% of maximal activity, pH 10.8: about 55% of maximal activity, reaction with pyruvate
5.5 - 8
-
pH 5.5: 40% of maximal activity of isoenzyme LDH-B4 and 60% of maximal activity of isoenzyme LDH-A2B2 and LDH-A4, pH 8.0: about 60% of maximal activity of isoenzyme LDH-A4, LDH-B4 and LDH-A4B4, reduction of pyruvate
6 - 8
Molinema dessetae
-
pH 6.0: 85% of maximal activity, pH 8.0: 45% of maximal activity, reduction of pyruvate
6.4 - 6.9
6.5 - 10
-
optimal pH range for pyruvate reduction and lactate oxidation is 6.5-7.0 and 9.0-10.0, respectively
6.6 - 10.8
Agama stellio stellio
-
pH 5.4: about 55% of maximal activity, pH 10.8: about 55% of maximal activity, reaction with lactate
7.7 - 9.5
-
pH 7.7: about 60% of maximal activity, pH 9.5: about 30% of maximal activity, reduction of pyruvate
8 - 9.6
Molinema dessetae
-
pH 8.0: 60% of maximal activity, pH 9.6: 45% of maximal activity, oxidation of lactate
8.5 - 10.7
-
pH 8.5: about 60% of maximal activity, pH 10.7: about 70% of maximal activity, oxidation of lactate
additional information