Reference on EC 3.4.21.108 - HtrA2 peptidase and Organism(s) Homo sapiens and UniProt Accession Q92743
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gray, C.W.; Ward, R.V.; Karran, E.; Turconi, S.; Rowles, A.; Viglienghi, D.; Southan, C.; Barton, A.; Fantom, K.G.; West, A.; Savopoulos, J.; Hassan, N.J.; Clinkenbeard, H.; Hanning, C.; Amegadzie, B.; Davis, J.B.; Dingwall, C.; Livi, G.P.; Creasy, C.L.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
Eur. J. Biochem.
267
5699-5710
2000
Homo sapiens (O43464), Mus musculus (Q9JIY5)
Faccio, L.; Fusco, C.; Chen, A.; Martinotti, S.; Bonventre, J.V.; Zervos, A.S.
Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia
J. Biol. Chem.
275
2581-2588
2000
Homo sapiens (O43464)
Hegde, R.; Srinivasula, S.M.; Zhang, Z.; Wassell, R.; Mukattash, R.; Cilenti, L.; DuBois, G.; Lazebnik, Y.; Zervos, A.S.; Fernandes-Alnemri, T.; Alnemri, E.S.
Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
J. Biol. Chem.
277
432-438
2002
Homo sapiens
Martins, L.M.; Iaccarino, I.; Tenev, T.; Gschmeissner, S.; Totty, N.F.; Lemoine, N.R.; Savopoulos, J.; Gray, C.W.; Creasy, C.L.; Dingwall, C.; Downward, J.
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif
J. Biol. Chem.
277
439-444
2002
Homo sapiens
Srinivasula, S.M.; Gupta, S.; Datta, P.; Zhang, Z.; Hegde, R.; Cheong, N.; Fernandes-Alnemri, T.; Alnemri, E.S.
Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
J. Biol. Chem.
278
31469-31472
2003
Homo sapiens
Martins, L.M.; Turk, B.E.; Cowling, V.; Borg, A.; Jarrell, E.T.; Cantley, L.C.; Downward, J.
Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi
J. Biol. Chem.
278
49417-49427
2003
Homo sapiens
Suzuki, Y.; Imai, Y.; Nakayama, H.; Takahashi, K.; Takio, K.; Takahashi, R.
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Mol. Cell
8
613-621
2001
Homo sapiens
Savopoulos, J.W.; Carter, P.S.; Turconi, S.; Pettman, G.R.; Karran, E.H.; Gray, C.W.; Ward, R.V.; Jenkins, O.; Creasy, C.L.
Expression, purification, and functional analysis of the human serine protease HtrA2
Protein Expr. Purif.
19
227-234
2000
Homo sapiens (O43464), Homo sapiens
Cilenti, L.; Kyrizis, G.A.; Soundarapandian, M.M.; Stratico, V.; Yerkes, A.; Park, K.M.; Sheridan, A.M.; Alnemri, E.S.; Bonventre, J.V.; Zervos, A.S.
Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells
Am. J. Physiol. Renal Physiol.
288
F371-F379
2005
Homo sapiens, Mus musculus, Mus musculus C57BL6
Sekine, K.; Hao, Y.; Suzuki, Y.; Takahashi, R.; Tsuruo, T.; Naito, M.
HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells
Biochem. Biophys. Res. Commun.
330
279-285
2005
Homo sapiens
Murwantoko, C.; Yano, M.; Ueta, Y.; Murasaki, A.; Kanda, H.; Oka, C.; Kawaichi, M.
Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
Biochem. J.
381
895-904
2004
Homo sapiens
Zhang, X.; Chang, Z
Temperature dependent protease activity and structural properties of human HtrA2 protease
Biochemistry (Moscow)
69
687-692
2004
Homo sapiens
Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R.
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
Cell Death Differ.
11
208-216
2004
Homo sapiens
Blink, E.; Maianski, N.A.; Alnemri, E.S.; Zervos, A.S.; Roos, D.; Kuijpers, T.W.
Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils
Cell Death Differ.
11
937-939
2004
Homo sapiens
Nam, M.K.; Seong, Y.M.; Park, H.J.; Choi, J.Y.; Kang, S.; Rhim, H.
The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity
Exp. Mol. Med.
38
26-43
2006
Homo sapiens
Hong, S.K.; Cha, M.K.; Kim, I.H.
Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2
Free Radic. Biol. Med.
40
275-284
2006
Homo sapiens
Strauss, K.M.; Martins, L.M.; Plun-Favreau, H.; Marx, F.P.; Kautzmann, S.; Berg, D.; Gasser, T.; Wszolek, Z.; Mueller, T.; Bornemann, A.; Wolburg, H.; Downward, J.; Riess, O.; Schulz, J.B.; Krueger, R.
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
Hum. Mol. Genet.
14
2099-2111
2005
Homo sapiens
Seong, Y.M.; Choi, J.Y.; Park, H.J.; Kim, K.J.; Ahn, S.G.; Seong, G.H.; Kim, I.K.; Kang, S.; Rhim, H.
Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP
J. Biol. Chem.
279
37588-37596
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Gupta, S.; Singh, R.; Datta, P.; Zhang, Z.; Orr, C.; Lu, Z.; Dubois, G.; Zervos, A.S.; Meisler, M.H.; Srinivasula, S.M.; Fernandes-Alnemri, T.; Alnemri, E.S.
The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity
J. Biol. Chem.
279
45844-45854
2004
Homo sapiens
Trencia, A.; Fiory, F.; Maitan, M.A.; Vito, P.; Barbagallo, A.P.; Perfetti, A.; Miele, C.; Ungaro, P.; Oriente, F.; Cilenti, L.; Zervos, A.S.; Formisano, P.; Beguinot, F.
Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15
J. Biol. Chem.
279
46566-46572
2004
Homo sapiens
Liu, M.L.; Liu, M.J.; Kim, J.M.; Kim, H.J.; Kim, J.H.; Hong, S.T.
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation
Mol. Cell
20
83-89
2005
Homo sapiens
Park, H.J.; Seong, Y.M.; Choi, J.Y.; Kang, S.; Rhim, H.
Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi
Neurosci. Lett.
357
63-67
2004
Homo sapiens (Q92743), Homo sapiens
Seong, Y.M.; Park, H.J.; Seong, G.H.; Choi, J.Y.; Yoon, S.J.; Min, B.R.; Kang, S.; Rhim, H.
N-terminal truncation circumvents proteolytic degradation of the human HtrA2/Omi serine protease in Escherichia coli: rapid purification of a proteolytically active HtrA2/Omi
Protein Expr. Purif.
33
200-208
2004
Homo sapiens (O43464), Homo sapiens, Mus musculus
Vande Walle, L.; Lamkanfi, M.; Vandenabeele, P.
The mitochondrial serine protease HtrA2/Omi: an overview
Cell Death Differ.
15
453-460
2008
Bacillus sp. (in: Bacteria), Bos taurus, Canis lupus familiaris, Clostridium sp., Drosophila melanogaster, Escherichia coli, Homo sapiens, Macaca mulatta, Mesorhizobium loti, Mus musculus, no activity in Caenorhabditis elegans, no activity in Mycoplasma genitalium, no activity in Mycoplasma pneumoniae, Rattus norvegicus
Park, H.J.; Kim, S.S.; Seong, Y.M.; Kim, K.H.; Goo, H.G.; Yoon, E.J.; Min, d.o..S.; Kang, S.; Rhim, H.
Beta-amyloid precursor protein is a direct cleavage target of HtrA2 serine protease. Implications for the physiological function of HtrA2 in the mitochondria
J. Biol. Chem.
281
34277-34287
2006
Homo sapiens, Mus musculus
Yang, L.; Sun, M.; Sun, X.M.; Cheng, G.Z.; Nicosia, S.V.; Cheng, J.Q.
Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212
J. Biol. Chem.
282
10981-10987
2007
Homo sapiens
Plun-Favreau, H.; Klupsch, K.; Moisoi, N.; Gandhi, S.; Kjaer, S.; Frith, D.; Harvey, K.; Deas, E.; Harvey, R.J.; McDonald, N.; Wood, N.W.; Martins, L.M.; Downward, J.
The mitochondrial protease HtrA2 is regulated by Parkinsons disease-associated kinase PINK1
Nat. Cell Biol.
9
1243-1252
2007
Homo sapiens, Mus musculus
Kuninaka, S.; Iida, S.I.; Hara, T.; Nomura, M.; Naoe, H.; Morisaki, T.; Nitta, M.; Arima, Y.; Mimori, T.; Yonehara, S.; Saya, H.
Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation
Oncogene
26
2395-2406
2007
Homo sapiens, Mus musculus, synthetic construct
Ma, X.; Kalakonda, S.; Srinivasula, S.M.; Reddy, S.P.; Platanias, L.C.; Kalvakolanu, D.V.
GRIM-19 associates with the serine protease HtrA2 for promoting cell death
Oncogene
26
4842-4849
2007
Homo sapiens
Plun-Favreau, H.; Gandhi, S.; Wood-Kaczmar, A.; Deas, E.; Yao, Z.; Wood, N.W.
What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinsons disease?
Ann. N. Y. Acad. Sci.
1147
30-36
2008
Homo sapiens
Bhuiyan, M.S.; Fukunaga, K.
Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury
Cardiovasc. ther.
26
224-232
2008
Homo sapiens
Marabese, M.; Mazzoletti, M.; Vikhanskaya, F.; Broggini, M.
HtrA2 enhances the apoptotic functions of p73 on bax
Cell Death Differ.
15
849-858
2008
Homo sapiens
Narkiewicz, J.; Klasa-Mazurkiewicz, D.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer
Clin. Biochem.
41
561-569
2008
Homo sapiens
Bhuiyan, M.S.; Fukunaga, K.
Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target
Curr. Drug Targets
10
372-383
2009
Homo sapiens
Inagaki, R.; Tagawa, K.; Qi, M.L.; Enokido, Y.; Ito, H.; Tamura, T.; Shimizu, S.; Oyanagi, K.; Arai, N.; Kanazawa, I.; Wanker, E.E.; Okazawa, H.
Omi /HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntingtons disease
Eur. J. Neurosci.
28
30-40
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Simon-Sanchez, J.; Singleton, A.B.
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
Hum. Mol. Genet.
17
1988-1993
2008
Homo sapiens (O43464)
Bogaerts, V.; Nuytemans, K.; Reumers, J.; Pals, P.; Engelborghs, S.; Pickut, B.; Corsmit, E.; Peeters, K.; Schymkowitz, J.; De Deyn, P.P.; Cras, P.; Rousseau, F.; Theuns, J.; Van Broeckhoven, C.
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease
Hum. Mutat.
29
832-840
2008
Homo sapiens (O43464), Homo sapiens
Han, C.; Nam, M.K.; Park, H.J.; Seong, Y.M.; Kang, S.; Rhim, H.
Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2
J. Microbiol. Biotechnol.
18
1197-1202
2008
Homo sapiens
Ross, O.A.; Soto, A.I.; Vilarino-Gueell, C.; Heckman, M.G.; Diehl, N.N.; Hulihan, M.M.; Aasly, J.O.; Sando, S.; Gibson, J.M.; Lynch, T.; Krygowska-Wajs, A.; Opala, G.; Barcikowska, M.; Czyzewski, K.; Uitti, R.J.; Wszolek, Z.K.; Farrer, M.J.
Genetic variation of Omi/HtrA2 and Parkinsons disease
Parkinsonism Relat. Disord.
14
539-543
2008
Homo sapiens
McCormick, A.L.; Roback, L.; Mocarski, E.S.
HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA)
PLoS Pathog.
4
e1000063
2008
Homo sapiens (O43464)
Krick, S.; Shi, S.; Ju, W.; Faul, C.; Tsai, S.Y.; Mundel, P.; Boettinger, E.P.
Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease
Proc. Natl. Acad. Sci. USA
105
14106-14111
2008
Chlorocebus aethiops, Homo sapiens, Mus musculus
Balakrishnan, M.P.; Cilenti, L.; Mashak, Z.; Popat, P.; Alnemri, E.S.; Zervos, A.S.
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death
Am. J. Physiol. Heart Circ. Physiol.
297
H643-H653
2009
Homo sapiens
Park, H.M.; Kim, G.Y.; Nam, M.K.; Seong, G.H.; Han, C.; Chung, K.C.; Kang, S.; Rhim, H.
The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity
Biochem. Biophys. Res. Commun.
387
537-542
2009
Homo sapiens, Mus musculus
Kieper, N.; Holmstroem, K.M.; Ciceri, D.; Fiesel, F.C.; Wolburg, H.; Ziviani, E.; Whitworth, A.J.; Martins, L.M.; Kahle, P.J.; Krueger, R.
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1
Exp. Cell Res.
316
1213-1224
2010
Drosophila melanogaster, Homo sapiens, Mus musculus
Kooistra, J.; Milojevic, J.; Melacini, G.; Ortega, J.
A new function of human HtrA2 as an amyloid-beta oligomerization inhibitor
J. Alzheimers Dis.
17
281-294
2009
Homo sapiens
Wang, C.Y.; Lin, Y.S.; Su, W.C.; Chen, C.L.; Lin, C.F.
Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis
Mol. Biol. Cell
20
4153-4161
2009
Homo sapiens
Hartkamp, J.; Carpenter, B.; Roberts, S.G.
The Wilms tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi
Mol. Cell
37
159-171
2010
Homo sapiens, Mus musculus
Kawamoto, Y.; Ito, H.; Kobayashi, Y.; Suzuki, Y.; Akiguchi, I.; Fujimura, H.; Sakoda, S.; Kusaka, H.; Hirano, A.; Takahashi, R.
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis
Neuropathol. Appl. Neurobiol.
36
331-344
2010
Homo sapiens
Narkiewicz, J.; Lapinska-Szumczyk, S.; Zurawa-Janicka, D.; Skorko-Glonek, J.; Emerich, J.; Lipinska, B.
Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer
Oncol. Rep.
21
1529-1537
2009
Homo sapiens
Essafi, A.; Hastie, N.D.
WT1 the oncogene: a tale of death and HtrA
Mol. Cell
37
153-155
2010
Homo sapiens
Liu, Q.B.; Liu, L.L.; Lu, Y.M.; Tao, R.R.; Huang, J.Y.; Shioda, N.; Moriguchi, S.; Fukunaga, K.; Han, F.; Lou, Y.J.
The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells
Toxicol. Appl. Pharmacol.
244
374-384
2010
Homo sapiens
Chien, J.
WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases
Future Oncol.
6
1233-1235
2010
Homo sapiens
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
Zurawa-Janicka, D.; Jarzab, M.; Polit, A.; Skorko-Glonek, J.; Lesner, A.; Gitlin, A.; Gieldon, A.; Ciarkowski, J.; Glaza, P.; Lubomska, A.; Lipinska, B.
Temperature-induced changes of HtrA2(Omi) protease activity and structure
Cell Stress Chaperones
18
35-51
2013
Homo sapiens (O43464)
Singh, N.; DSouza, A.; Cholleti, A.; Sastry, G.M.; Bose, K.
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity
FEBS J.
281
2456-2470
2014
Homo sapiens (O43464)
Luo, F.; Wei, L.; Sun, C.; Chen, X.; Wang, T.; Li, Y.; Liu, Z.; Chen, Z.; Xu, P.
HtrA2/Omi is involved in 6-OHDA-induced endoplasmic reticulum stress in SH-SY5Y cells
J. Mol. Neurosci.
47
120-127
2012
Homo sapiens (O43464), Homo sapiens
Bejugam, P.; Kuppili, R.; Singh, N.; Gadewal, N.; Chaganti, L.; Sastry, G.; Bose, K.
Allosteric regulation of serine protease HtrA2 through novel non-canonical substrate binding pocket
PLoS ONE
8
e55416
2013
Homo sapiens (O43464)
Winkler, J.; Rand, M.L.; Schmugge, M.; Speer, O.
Omi/HtrA2 and XIAP are components of platelet apoptosis signalling
Thromb. Haemost.
109
532-539
2013
Homo sapiens (O43464)
Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
Design and synthesis of new substrates of HtrA2 protease
Anal. Biochem.
475
44-52
2015
Homo sapiens (O43464)
Jarzab, M.; Wenta, T.; Zurawa-Janicka, D.; Polit, A.; Gieldon, A.J.; Wysocka, M.; Glaza, P.; Skorko-Glonek, J.; Ciarkowski, J.; Lesner, A.; Lipinska, B.
Intra- and intersubunit changes accompanying thermal activation of the HtrA2(Omi) protease homotrimer
Biochim. Biophys. Acta
1864
283-296
2016
Homo sapiens (O43464)
Wagh, A.R.; Bose, K.
Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2
Biosci. Rep.
38
BSR20181072
2018
Homo sapiens (O43464), Homo sapiens
Merski, M.; Moreira, C.; Abreu, R.M.; Ramos, M.J.; Fernandes, P.A.; Martins, L.M.; Pereira, P.J.B.; Macedo-Ribeiro, S.
Molecular motion regulates the activity of the mitochondrial serine protease HtrA2
Cell Death Dis.
8
e3119
2017
Homo sapiens (O43464), Homo sapiens
Hu, Y.; Bi, Y.; Yao, D.; Wang, P.; Li, Y.
Omi/HtrA2 protease associated cell apoptosis participates in blood-brain barrier dysfunction
Front. Mol. Neurosci.
12
48
2019
Homo sapiens (O43464), Homo sapiens
Sun, M.L.; Sun, L.M.; Wang, Y.Q.
Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes
J. Mol. Recognit.
31
e2698
2018
Homo sapiens (O43464)
Lucotte, B.; Tajhizi, M.; Alkhatib, D.; Samuelsson, E.; Wiehager, B.; Schedin-Weiss, S.; Sundstrom, E.; Winblad, B.; Tjernberg, L.; Behbahani, H.
Stress conditions increase vimentin cleavage by Omi/HtrA2 protease in human primary neurons and differentiated neuroblastoma cells
Mol. Neurobiol.
52
1077-1092
2015
Homo sapiens (O43464), Homo sapiens
Glaza, P.; Osipiuk, J.; Wenta, T.; Zurawa-Janicka, D.; Jarzab, M.; Lesner, A.; Banecki, B.; Skorko-Glonek, J.; Joachimiak, A.; Lipinska, B.
Structural and functional analysis of human HtrA3 protease and its subdomains
PLoS ONE
10
e0131142
2015
Homo sapiens (P83110)
