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Literature summary for 3.4.21.108 extracted from
- Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target (2009), Curr. Drug Targets, 10, 372-383.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | HtrA2 is linked to cancer and neurodegeneration, like Alzheimers disease, Parkinsons disease, Huntingtons disease, and brain, kidney and myocardial ischemia, reperfusion | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid | UCF-101 | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | released into the cytosol upon apoptotic stimuli | Homo sapiens | 5829 | - |
| mitochondrial intermembrane space | - |
Homo sapiens | 5758 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
cleaved, activated form | Homo sapiens |
| 50000 | - |
precursor HtrA2 | Homo sapiens |
| 110000 | - |
trimer, determined by gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| amyloid precursor protein + H2O | APP | Homo sapiens | ? | - |
? | |
| Apollon + H2O | BRUCE-apollon | Homo sapiens | ? | - |
? | |
| beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| Fas-Fas L + H2O | - |
Homo sapiens | ? | - |
? | |
| FLIP + H2O | Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein | Homo sapiens | ? | - |
? | |
| glycoprotein alpha1 + H2O | - |
Homo sapiens | ? | - |
? | |
| HS1-associated protein X1 + H2O | HAX-1 | Homo sapiens | ? | - |
? | |
| hyaluronidase + H2O | - |
Homo sapiens | ? | - |
? | |
| inhibitor of apoptosis + H2O | IAP | Homo sapiens | ? | - |
? | |
| PED-PEA 15 + H2O | death effector domain-containing protein | Homo sapiens | ? | - |
? | |
| WARTS kinase + H2O | WARTS, WTS, large tumor-suppressor 1 mitotic kinase | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotrimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high temperature requirement A2 | - |
Homo sapiens |
| serine protease HtrA2/Omi | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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