Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heat shock | pre-incubation of Omi at 42°C for 30 min results in increased proteolytic activity | Homo sapiens | |
X-linked inhibitor of apoptosis protein | i.e. XIAP, binding of XIAP to the Reaper motif of the enzyme results in a marked increase in proteolytic activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
PDZ domain | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-IRRVSYSF(Dnp)KK + H2O | best substrate | Homo sapiens | ? | - |
? | |
(7-methoxycoumarin-4-yl)acetyl-VTLCAVPS(Dnp)KK + H2O | cleavage occurs between cysteine and alanine | Homo sapiens | ? | - |
? | |
beta-casein + H2O | main selectivity at position P1 is for non-polar aliphatic amino acids, in particular valine, isoleucine and methionine. At the P2 and P3 positions arginine is selected most strongly with a secondary selection for other hydrophilic residues | Homo sapiens | ? | - |
? | |
additional information | role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HtrA2/Omi | - |
Homo sapiens |