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Literature summary for 3.4.21.108 extracted from
- WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases (2010), Future Oncol., 6, 1233-1235.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | HtrA2-mediated proteolysis of WT1 may directly contribute to the effect of cytotoxic drugs warrants | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Wilms' tumor suppressor protein WT1 + H2O | Homo sapiens | - |
? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Wilms' tumor suppressor protein WT1 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high temperature requirement A2 protease | - |
Homo sapiens |
| HtrA2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | HtrA2 acts as an apoptotic factor which targets inhibitors of apoptosis during apoptosis, and thereby enhances caspase activation and caspase-mediated cell death | Homo sapiens |
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Release 2023.1 (January 2023)
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