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Literature summary for 3.4.21.108 extracted from

  • Wysocka, M.; Wojtysiak, A.; Okonska, M.; Gruba, N.; Jarzab, M.; Wenta, T.; Lipinska, B.; Grzywa, R.; Sienczyk, M.; Rolka, K.; Lesner, A.
    Design and synthesis of new substrates of HtrA2 protease (2015), Anal. Biochem., 475, 44-52 .
    View publication on PubMed
Search for more literature for 3.4.21.108

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0227
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2) pH 8.0, temperature not specified in the publication Homo sapiens
0.0315
-
 2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.0391
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.1072
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.1773
-
 2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O43464 isoform Htra2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens 2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-His-Tyr(3-NO2)-NH2
-
 ?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens 2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
-
 ?
2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens 2-aminobenzoyl-Ile-Met-Thr + Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2
-
 ?
2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens 2-aminobenzoyl-Ile-Met-Val + Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2
-
 ?
2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 + H2O
-
 Homo sapiens 2-aminobenzoyl-Ile-Met-Val + Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2
-
 ?

Synonyms

Synonyms Comment Organism
HtrA2
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.08
-
 2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.17
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.22
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
0.33
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2) pH 8.0, temperature not specified in the publication Homo sapiens
31.5
-
 2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.68
-
 2-aminobenzoyl-Ile-Met-Val-Ser-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
1.58
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Trp-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
4.117
-
 2-aminobenzoyl-Ile-Met-Val-Abu-Tyr-Met-Phe-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
5.62
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-His-Tyr(3-NO2)-NH2 pH 8.0, temperature not specified in the publication Homo sapiens
14.53
-
 2-aminobenzoyl-Ile-Met-Thr-Abu-Tyr-Met-Phe-Tyr(3-NO2) pH 8.0, temperature not specified in the publication Homo sapiens