Application | Comment | Organism |
---|---|---|
medicine | heterozygous G399S mutation in Parkinson's disease patients, which is absent in healthy controls, a A141S polymorphism is associated with Parkinson's disease, both mutations result in defective activation of Omi/HtrA2 and mitochondrial dysfunction associated with altered mitochondrial morphology | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 Codon Plus (DE3)-RIL | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
mitochondrion | predominant localisation, enlarged mitochondria with disorganized cristae in mutant cells | Homo sapiens | 5739 | - |
additional information | halo of Lewy bodies from patients with pathologically confirmed idiopathic Parkinson's disease | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
518 Parkinson's disease patients | - |
Purification (Comment) | Organism |
---|---|
by glutathione-Sepharose beads | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | stem sections and cortical slices from patients with pathologically confirmed idiopathic Parkinson's disease | Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
kidney | from human embryos | Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Storage Stability | Organism |
---|---|
-20°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
PDZ-interacting peptides + H2O | - |
Homo sapiens | ? | - |
? | |
X-linked inhibitor of apoptosis protein + H2O | BIR2 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Omi/HtrA2 | - |
Homo sapiens |