Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | UV irradiation leads to an almost complete disappearance of mitochondrial Omi/HtrA2 and a parallel appearance of Omi/HtrA2 in the cytoplasm, induction of Omi/HtrA2 binding to ped/pea-15 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in HeLa cells and HEK-293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ucf-101 | inhibits degradation of endogenous ped/pea-15 by Omi/HtrA2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
kidney | from embryos | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ped/pea-15 | HtrA2 is a specific interactor of the ped/pea-15 death effector domain and leads to its degradation | Homo sapiens | ? | - |
? | |
X-linked inhibitor of apoptosis protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Omi/HtrA2 | - |
Homo sapiens |
serine protease | - |
Homo sapiens |