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Literature summary for 3.4.21.108 extracted from

  • Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R.
    Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways (2004), Cell Death Differ., 11, 208-216.
    View publication on PubMed
Search for more literature for 3.4.21.108

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) pLysS Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion intermembrane space Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by nickel affinity chromatography and HiTrap desalting Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell human cervical carcinoma Homo sapiens
-
kidney from human embryos Homo sapiens
-

Storage Stability

Storage Stability Organism
-80°C, HEPES-KOH buffer, pH 7.5 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
unidentified substrate + H2O its cleavage by Omi/HtrA2 leads to permeabilization of the mitochondria outer membrane and release of chytochrome c followed by enhanced caspase activation Homo sapiens ?
-
 ?
X-linked inhibitor of apoptosis protein + H2O Omi/HtrA2 cleaves as well as directly binds and inactivates X-linked inhibitor of apoptosis protein to promote caspase activation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Omi/HtrA2
-
 Homo sapiens
serine protease
-
 Homo sapiens