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Literature summary for 3.4.21.108 extracted from
- Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury (2008), Cardiovasc. ther., 26, 224-232.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | therapeutic interventions that inhibit HtrA2 expression, translocation, or protease activity may provide attractive therapeutics in the treatment of cardiovascular diseases | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid | UCF-101 | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | translocation from mitochondria to cytosol | Homo sapiens | 5829 | - |
| mitochondrion | translocation from mitochondria to cytosol | Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36000 | - |
predicted | Homo sapiens |
| 110000 | - |
determined by gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cardiac myocyte | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotrimer | - |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| high temperature requirement A2 serine protease | - |
Homo sapiens |
| HtrA2 | - |
Homo sapiens |
| HtrA2 serine protease | - |
Homo sapiens |
| HtrA2/Omi | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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