Reference on EC 3.4.19.12 - ubiquitinyl hydrolase 1
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wilkinson, K.D.
Ubiquitin C-terminal hydroase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
660-663
1998
Bos taurus, Drosophila melanogaster, Homo sapiens, Rattus norvegicus
-
Johnston, S.C.; Larsen, C.N.; Cook, W.J.; Wilkinson, K.D.; Hill, C.P.
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution
EMBO J.
16
3787-3796
1997
Homo sapiens
Mildner, A.M.; Paddock, D.J.; LeCureux, L.W.; Leone, J.W.; Anderson, D.C.; Tomasselli, A.G.; Heinrikson, R.L.
Production of chemokines CTAPIII and NAP/2 by digestion of recombinant ubiquitin-CTAPII with yeast ubiquitin C-terminal hydrolase and human immunodeficiency virus protease
Protein Expr. Purif.
16
347-354
1999
Saccharomyces cerevisiae
Woo, S.K.; Baek, S.H.; Lee, J.L.; Yoo, Y.J.; Cho, C.M.; Kang, M.S.; Chung, C.H.
Purification and characterization of a new ubiquitin C-terminal hydrolase (UCH-1) with isopeptidase activity from chick skeletal muscle
J. Biochem.
121
684-689
1997
Gallus gallus
Lowe, J.; McDermott, H.; Landon, M.; Mayer, R.J.; Wilkinson, K.D.
Ubiquitin carboxyl-terminal hydrolase (PGP9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases
J. Pathol.
161
153-160
1990
Homo sapiens
Duerksen-Hughes, P.J.; Williamson, M.M.; Wilkinson, K.D.
Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases
Biochemistry
28
8530-8536
1989
Bos taurus
Woo, S.K.; Lee, J.I.; Park, I.K.; Yoo, Y.J.; Cho, C.M.; Kang, M.S.; Ha, D.B.; Tanaka, K.; Chung, C.H.
Multiple Ubiquitin C-terminal Hydrolases from Chick Skeletal Muscle
J. Biol. Chem.
270
18766-18773
1995
Gallus gallus
Moskovitz, J.
Characterization of the 30-kDa enzyme from red blood cells that cleaves ubiquitin-protein conjugates
Biochem. Biophys. Res. Commun.
205
354-360
1994
Bos taurus, Homo sapiens
Pickart, C.M.; Rose, I.A.
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides
J. Biol. Chem.
260
7903-7910
1985
Homo sapiens
Liu, C.C.; Miller, H.I.; Kohr, W.J.; Silber, J.I.
Purification of a ubiquitin protein peptidase from yeast with efficient in vitro assays
J. Biol. Chem.
264
20331-20338
1989
Saccharomyces cerevisiae
Larsen, C.N.; Price, J.S.; Wilkinson, K.D.
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues
Biochemistry
35
6735-6744
1996
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
Larsen, C.N.; Krantz, B.A.; Wilkinson, K.D.
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases
Biochemistry
37
3358-3368
1998
Homo sapiens
Mayer, A.N.; Wilkinson, K.D.
Detection, resolution, and nomenclature of multiple ubiquitin carboxyl-terminal esterases from bovine calf thymus
Biochemistry
28
166-172
1989
Bos taurus
Kanda, F.; Sykes, D.E.; Yasuda, H.; Sandberg, A.A.; Matsui, S.
Substrate recognition of isopeptidase: specific cleavage of the epsilon-(alpha-glycyl)lysine linkage in ubiquitin-protein conjugates
Biochim. Biophys. Acta
870
64-75
1986
Bos taurus
Falquet, L.; Paquet, N.; Frutiger, S.; Hughes, G.J.; Hoang-Van, K.; Jaton, J.C.
A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro
FEBS Lett.
359
73-77
1995
Homo sapiens
Matsui, S.; Sandberg, A.A.; Negoro, S.; Seon, B.K.; Goldstein, G.
Isopeptidase: a novel eukaryotic enzyme that cleaves isopeptide bonds
Proc. Natl. Acad. Sci. USA
79
1535-1539
1982
amphibia, Saccharomyces cerevisiae, Gallus gallus, Cricetulus griseus, eukaryota, Mammalia, no activity in Escherichia coli
Melandri, F.; Grenier, L.; Plamondon, L.; Huskey, W.P.; Stein, R.L.
Kinetic studies on the inhibition of isopeptidase T by ubiquitin aldehyde
Biochemistry
35
12893-12900
1996
Oryctolagus cuniculus
Lam, Y.A.; DeMartino, G.N.; Pickart, C.M.; Cohen, R.E.
Specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26 S proteasomes
J. Biol. Chem.
272
28438-28446
1997
Bos taurus
Baek, S.H.; Woo, S.K.; Lee, J.I.; Yoo, Y.J.; Cho, C.M.; Kang, M.S.; Tanaka, K.; Chung, C.H.
New de-ubiquitinating enzyme, ubiquitin C-terminal hydrolase 8, in chick skeletal muscle
Biochem. J.
325
325-330
1997
Gallus gallus
Naviglio, S.; Mattecucci, C.; Matoskova, B.; Nagase, T.; Nomura, N.; Di Fiore, P.P.; Draetta, G.F.
UBPY: a growth-regulated human ubiquitin isopeptidase
EMBO J.
17
3241-3250
1998
Homo sapiens (P40818), Homo sapiens
Gong, L.; Kamitani, T.; Millas, S.; Yeh, E.T.
Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins
J. Biol. Chem.
275
14212-14216
2000
Homo sapiens (Q9UK80), Homo sapiens
Dupre, S.; Haguenauer-Tsapis, R.
Deubiquitination step in the endocytic pathway of yeast plasma membrane proteins: crucial role of Doa4p ubiquitin isopeptidase
Mol. Cell. Biol.
21
4482-4494
2001
Saccharomyces cerevisiae
Mullally, J.E.; Moos, P.J.; Edes, K.; Fitzpatrick, F.A.
Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway
J. Biol. Chem.
276
30366-30373
2001
Homo sapiens
Gabriel, J.M.; Lacombe, T.; Carobbio, S.; Paquet, N.; Bisig, R.; Cox, J.A.; Jaton, J.C.
Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T
Biochemistry
41
13755-13766
2002
Homo sapiens
Kaitna, S.; Schnabel, H.; Schnabel, R.; Hyman, A.A.; Glotzer, M.
A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo
J. Cell Sci.
115
2293-2302
2002
Saccharomyces cerevisiae, Caenorhabditis elegans
Nishikawa, K.; Li, H.; Kawamura, R.; Osaka, H.; Wang, Y.L.; Hara, Y.; Hirokawa, T.; Manago, Y.; Amano, T.; Noda, M.; Aoki, S.; Wada, K.
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants
Biochem. Biophys. Res. Commun.
304
176-183
2003
Homo sapiens (P09936), Homo sapiens
Osaka, H.; Wang, Y.L.; Takada, K.; Takizawa, S.; Setsuie, R.; Li, H.; Sato, Y.; Nishikawa, K.; Sun, Y.J.; Sakurai, M.; Harada, T.; Hara, Y.; Kimura, I.; Chiba, S.; Namikawa, K.; Kiyama, H.; Noda, M.; Aoki, S.; Wada, K.
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
Hum. Mol. Genet.
12
1945-1958
2003
Mus musculus, Mus musculus (Q9R0P9)
Harada, T.; Harada, C.; Wang, Y.L.; Osaka, H.; Amanai, K.; Tanaka, K.; Takizawa, S.; Setsuie, R.; Sakurai, M.; Sato, Y.; Noda, M.; Wada, K.
Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo
Am. J. Pathol.
164
59-64
2004
Mus musculus
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sato, Y.; Sakurai, M.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
Am. J. Pathol.
165
1367-1374
2004
Mus musculus, Mus musculus (Q9R0P9)
Son, O.L.; Kim, H.T.; Ji, M.H.; Yoo, K.W.; Rhee, M.; Kim, C.H.
Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish
Biochem. Biophys. Res. Commun.
312
601-607
2003
Danio rerio, Danio rerio (Q6YI49), Homo sapiens (P09936), Homo sapiens
Naito, S.; Mochizuki, H.; Yasuda, T.; Mizuno, Y.; Furusaka, M.; Ikeda, S.; Adachi, T.; Shimizu, H.M.; Suzuki, J.; Fujiwara, S.; Okada, T.; Nishikawa, K.; Aoki, S.; Wada, K.
Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering
Biochem. Biophys. Res. Commun.
339
717-725
2006
Homo sapiens
Case, A.; Stein, R.L.
Mechanistic studies of ubiquitin C-terminal hydrolase L1
Biochemistry
45
2443-2452
2006
Homo sapiens, Homo sapiens (P09936)
Kwon, J.; Wang, Y.L.; Setsuie, R.; Sekiguchi, S.; Sakurai, M.; Sato, Y.; Lee, W.W.; Ishii, Y.; Kyuwa, S.; Noda, M.; Wada, K.; Yoshikawa, Y.
Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
Biol. Reprod.
71
515-521
2004
Mus musculus, Mus musculus (P15347), Mus musculus (Q9R0P9)
Kwon, J.; Mochida, K.; Wang, Y.L.; Sekiguchi, S.; Sankai, T.; Aoki, S.; Ogura, A.; Yoshikawa, Y.; Wada, K.
Ubiquitin C-terminal hydrolase L-1 is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
Biol. Reprod.
73
29-35
2005
Mus musculus, Mus musculus (Q9R0P9)
Liu, Y.; Lashuel, H.A.; Choi, S.; Xing, X.; Case, A.; Ni, J.; Yeh, L.A.; Cuny, G.D.; Stein, R.L.; Lansbury, P.T., Jr.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
Chem. Biol.
10
837-846
2003
Homo sapiens
Kwon, J.; Sekiguchi, S.; Wang, Y.L.; Setsuie, R.; Yoshikawa, Y.; Wada, K.
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis
Exp. Anim.
55
35-43
2006
Mus musculus, Mus musculus (Q9R0P9)
Wood, M.A.; Kaplan, M.P.; Brensinger, C.M.; Guo, W.; Abel, T.
Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
Hippocampus
15
610-621
2005
Mus musculus, Mus musculus (Q9JKB1)
Choi, J.; Levey, A.I.; Weintraub, S.T.; Rees, H.D.; Gearing, M.; Chin, L.S.; Li, L.
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
J. Biol. Chem.
279
13256-13264
2004
Homo sapiens, Homo sapiens (P09936)
McCullough, J.; Clague, M.J.; Urbe, S.
AMSH is an endosome-associated ubiquitin isopeptidase
J. Cell Biol.
166
487-492
2004
Homo sapiens
Sakurai, M.; Ayukawa, K.; Setsuie, R.; Nishikawa, K.; Hara, Y.; Ohashi, H.; Nishimoto, M.; Abe, T.; Kudo, Y.; Sekiguchi, M.; Sato, Y.; Aoki, S.; Noda, M.; Wada, K.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
J. Cell Sci.
119
162-171
2006
Homo sapiens, Mus musculus, Mus musculus (Q9R0P9)
Manago, Y.; Kanahori, Y.; Shimada, A.; Sato, A.; Amano, T.; Sato-Sano, Y.; Setsuie, R.; Sakurai, M.; Aoki, S.; Wang, Y.L.; Osaka, H.; Wada, K.; Noda, M.
Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1
J. Neurochem.
92
1061-1072
2005
Homo sapiens, Rattus norvegicus
Barrachina, M.; Castano, E.; Dalfo, E.; Maes, T.; Buesa, C.; Ferrer, I.
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
Neurobiol. Dis.
22
265-273
2006
Homo sapiens
Sekiguchi, S.; Takatori, A.; Negishi, T.; Kwon, J.; Kokubo, T.; Ishii, Y.; Kyuwa, S.; Yoshikawa, Y.
Localization of ubiquitin carboxyl-terminal hydrolase-L1 in cynomolgus monkey placentas
Placenta
26
99-103
2005
Macaca fascicularis, Macaca fascicularis (Q60HC8)
Das, C.; Hoang, Q.Q.; Kreinbring, C.A.; Luchansky, S.J.; Meray, R.K.; Ray, S.S.; Lansbury, P.T.; Ringe, D.; Petsko, G.A.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1
Proc. Natl. Acad. Sci. USA
103
4675-4680
2006
Homo sapiens (P15374), Homo sapiens
Chang, C.; Chang, A.Y.W.; Chan, S.H.H.
De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication
Shock
22
575-581
2004
Rattus norvegicus, Rattus norvegicus (Q00981)
Solano, S.M.; Miller, D.W.; Augood, S.J.; Young, A.B.; Penney, J.B.
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinsons disease
Ann. Neurol.
47
201-210
2000
Homo sapiens (P09936), Homo sapiens
Shen, H.; Sikorska, M.; Leblanc, J.; Walker, P.R.; Liu, Q.Y.
Oxidative stress regulated expression of ubiquitin carboxyl-terminal hydrolase-L1: role in cell survival
Apoptosis
11
1049-1059
2006
Homo sapiens, Homo sapiens (P09936)
Dong, X.; Yagita, K.; Zhang, J.; Okamura, H.
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1
Biomed. Res.
26
43-49
2005
Mus musculus (Q9R0P9)
Gong, B.; Cao, Z.; Zheng, P.; Vitolo, O.V.; Liu, S.; Staniszewski, A.; Moolman, D.; Zhang, H.; Shelanski, M.; Arancio, O.
Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
Cell
126
775-788
2006
Mus musculus, Mus musculus (Q9R0P9)
Sekiguchi, S.; Yoshikawa, Y.; Tanaka, S.; Kwon, J.; Ishii, Y.; Kyuwa, S.; Wada, K.; Nakamura, S.; Takahashi, K.
Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse
Exp. Anim.
52
365-369
2003
Mus musculus (Q9R0P9), Mus musculus
Poon, H.F.; Hensley, K.; Thongboonkerd, V.; Merchant, M.L.; Lynn, B.C.; Pierce, W.M.; Klein, J.B.; Calabrese, V.; Butterfield, D.A.
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
Free Radic. Biol. Med.
39
453-462
2005
Mus musculus (Q9R0P9), Mus musculus
Misaghi, S.; Galardy, P.J.; Meester, W.J.; Ovaa, H.; Ploegh, H.L.; Gaudet, R.
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate
J. Biol. Chem.
280
1512-1520
2005
Homo sapiens (P15374), Homo sapiens
Mochida, K.; Matsubara, T.; Kudo, H.; Andoh, T.; Ueda, H.; Adachi, S.; Yamauchi, K.
Molecular cloning and immunohistochemical localization of ubiquitin C-terminal hydrolase expressed in testis of a teleost, the Nile Tilapia, Oreochromis niloticus
J. Exp. Zool.
293
368-383
2002
Oreochromis niloticus
Castegna, A.; Thongboonkerd, V.; Klein, J.; Lynn, B.C.; Wang, Y.L.; Osaka, H.; Wada, K.; Butterfield, D.A.
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins
J. Neurochem.
88
1540-1546
2004
Mus musculus (Q9R0P9), Mus musculus
Alexander-Kaufman, K.; James, G.; Sheedy, D.; Harper, C.; Matsumoto, I.
Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study
Mol. Psychiatry
11
56-65
2006
Homo sapiens (P09936), Homo sapiens
Wang, Y.L.; Liu, W.; Sun, Y.J.; Kwon, J.; Setsuie, R.; Osaka, H.; Noda, M.; Aoki, S.; Yoshikawa, Y.; Wada, K.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice
Mol. Reprod. Dev.
73
40-49
2006
Mus musculus (Q9R0P9), Mus musculus
Facheris, M.; Strain, K.J.; Lesnick, T.G.; de Andrade, M.; Bower, J.H.; Ahlskog, J.E.; Cunningham, J.M.; Lincoln, S.; Farrer, M.J.; Rocca, W.A.; Maraganore, D.M.
UCHL1 is associated with Parkinsons disease: A case-unaffected sibling and case-unrelated control study
Neurosci. Lett.
381
131-134
2005
Homo sapiens (P09936)
Wicks, S.J.; Haros, K.; Maillard, M.; Song, L.; Cohen, R.E.; Dijke, P.T.; Chantry, A.
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling
Oncogene
24
8080-8084
2005
Homo sapiens (Q9Y5K5), Homo sapiens
Sano, Y.; Furuta, A.; Setsuie, R.; Kikuchi, H.; Wang, Y.L.; Sakurai, M.; Kwon, J.; Noda, M.; Wada, K.
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice
Am. J. Pathol.
169
132-141
2006
Mus musculus
Sekiguchi, S.; Kwon, J.; Yoshida, E.; Hamasaki, H.; Ichinose, S.; Hideshima, M.; Kuraoka, M.; Takahashi, A.; Ishii, Y.; Kyuwa, S.; Wada, K.; Yoshikawa, Y.
Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy
Am. J. Pathol.
169
1722-1729
2006
Mus musculus
Hassiepen, U.; Eidhoff, U.; Meder, G.; Bulber, J.F.; Hein, A.; Bodendorf, U.; Lorthiois, E.; Martoglio, B.
A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate
Anal. Biochem.
371
201-207
2007
Homo sapiens
Takami, Y.; Nakagami, H.; Morishita, R.; Katsuya, T.; Cui, T.X.; Ichikawa, T.; Saito, Y.; Hayashi, H.; Kikuchi, Y.; Nishikawa, T.; Baba, Y.; Yasuda, O.; Rakugi, H.; Ogihara, T.; Kaneda, Y.
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation
Arterioscler. Thromb. Vasc. Biol.
27
2184-2190
2007
Homo sapiens
Schweitzer, K.; Decker, E.; Zhu, L.; Miller, R.E.; Mirra, S.S.; Spina, S.; Ghetti, B.; Wang, M.; Murrell, J.
Aberrantly regulated proteins in frontotemporal dementia
Biochem. Biophys. Res. Commun.
348
465-472
2006
Homo sapiens (P09936), Homo sapiens
Wicks, S.J.; Grocott, T.; Haros, K.; Maillard, M.; ten Dijke, P.; Chantry, A.
Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway
Biochem. Soc. Trans.
34
761-763
2006
Homo sapiens
Luchansky, S.J.; Lansbury, P.T.; Stein, R.L.
Substrate recognition and catalysis by UCH-L1
Biochemistry
45
14717-14725
2006
synthetic construct
Yi, Y.J.; Manandhar, G.; Sutovsky, M.; Li, R.; Jonakova, V.; Oko, R.; Park, C.S.; Prather, R.S.; Sutovsky, P.
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization
Biol. Reprod.
77
780-793
2007
Sus scrofa
Hirayama, K.; Aoki, S.; Nishikawa, K.; Matsumoto, T.; Wada, K.
Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening
Bioorg. Med. Chem.
15
6810-6818
2007
Homo sapiens
Mermerian, A.H.; Case, A.; Stein, R.L.; Cuny, G.D.
Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors
Bioorg. Med. Chem. Lett.
17
3729-3732
2007
Mus musculus
Carolan, B.J.; Heguy, A.; Harvey, B.G.; Leopold, P.L.; Ferris, B.; Crystal, R.G.
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers
Cancer Res.
66
10729-10740
2006
Homo sapiens
Miyoshi, Y.; Nakayama, S.; Torikoshi, Y.; Tanaka, S.; Ishihara, H.; Taguchi, T.; Tamaki, Y.; Noguchi, S.
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer
Cancer Sci.
97
523-529
2006
Homo sapiens
Lansbury, P.T.
Improving synaptic function in a mouse model of AD
Cell
126
655-657
2006
Aplysia sp., Homo sapiens, Mus musculus
Bifsha, P.; Landry, K.; Ashmarina, L.; Durand, S.; Seyrantepe, V.; Trudel, S.; Quiniou, C.; Chemtob, S.; Xu, Y.; Gravel, R.A.; Sladek, R.; Pshezhetsky, A.V.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway
Cell Death Differ.
14
511-523
2007
Mus musculus, Homo sapiens (P09936), Homo sapiens
Roth, G.; Freund, S.; Moehrle, B.; Woellner, K.; Bruenjes, J.; Gauglitz, G.; Wiesmueller, K.H.; Jung, G.
Ubiquitin binds to a short peptide segment of hydrolase UCH-L3: a study by FCS, RIfS, ITC and NMR
Chembiochem
8
323-331
2007
Homo sapiens
Gong, B.; Leznik, E.
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders
Drug News Perspect.
20
365-370
2007
Homo sapiens
Nikko, E.; Andre, B.
Split-ubiquitin two-hybrid assay to analyze protein-protein interactions at the endosome: application to Saccharomyces cerevisiae Bro1 interacting with ESCRT complexes, the Doa4 ubiquitin hydrolase, and the Rsp5 ubiquitin ligase
Eukaryot. Cell
6
1266-1277
2007
Saccharomyces cerevisiae
Sakurai, M.; Sekiguchi, M.; Zushida, K.; Yamada, K.; Nagamine, S.; Kabuta, T.; Wada, K.
Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
Eur. J. Neurosci.
27
691-701
2008
Mus musculus, Mus musculus C57/BL6J
Mauri, P.L.; Riva, M.; Ambu, D.; De Palma, A.; Secundo, F.; Benazzi, L.; Valtorta, M.; Tortora, P.; Fusi, P.
Ataxin-3 is subject to autolytic cleavage
FEBS J.
273
4277-4286
2006
Mus musculus (Q9CVD2)
Kabuta, T.; Setsuie, R.; Mitsui, T.; Kinugawa, A.; Sakurai, M.; Aoki, S.; Uchida, K.; Wada, K.
Aberrant molecular properties shared by familial Parkinsons disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1
Hum. Mol. Genet.
17
1482-1496
2008
Homo sapiens
Vigneswara, V.; Lowenson, J.D.; Powell, C.D.; Thakur, M.; Bailey, K.; Clarke, S.; Ray, D.E.; Carter, W.G.
Proteomic identification of novel substrates of a protein isoaspartyl methyltransferase repair enzyme
J. Biol. Chem.
281
32619-32629
2006
Mus musculus (Q9R0P9)
Meray, R.K.; Lansbury, P.T.
Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1
J. Biol. Chem.
282
10567-10575
2007
Homo sapiens
Butterworth, M.B.; Edinger, R.S.; Ovaa, H.; Burg, D.; Johnson, J.P.; Frizzell, R.A.
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel
J. Biol. Chem.
282
37885-37893
2007
Mus musculus
Sakai, T.; Tochio, H.; Tenno, T.; Ito, Y.; Kokubo, T.; Hiroaki, H.; Shirakawa, M.
In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes
J. Biomol. NMR
36
179-188
2006
Xenopus laevis
Baska, K.M.; Manandhar, G.; Feng, D.; Agca, Y.; Tengowski, M.W.; Sutovsky, M.; Yi, Y.J.; Sutovsky, P.
Mechanism of extracellular ubiquitination in the mammalian epididymis
J. Cell. Physiol.
215
684-696
2008
Bos taurus
Toda, T.; Nakamura, M.; Morisawa, H.; Hirota, M.
Proteomic identification of oxidative-stress-reporting biomarkers differentially secreted from human neuroblastoma SH-SY5Y cells
J. Electrophor.
51
21-26
2007
Homo sapiens (P09936)
-
Rolen, U.; Kobzeva, V.; Gasparjan, N.; Ovaa, H.; Winberg, G.; Kisseljov, F.; Masucci, M.G.
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines
Mol. Carcinog.
45
260-269
2006
Homo sapiens
Artavanis-Tsakonas, K.; Misaghi, S.; Comeaux, C.A.; Catic, A.; Spooner, E.; Duraisingh, M.T.; Ploegh, H.L.
Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum
Mol. Microbiol.
61
1187-1195
2006
Plasmodium falciparum
Fujino, R.S.; Ishikawa, Y.; Tanaka, K.; Kanatsu-Shinohara, M.; Tamura, K.; Kogo, H.; Shinohara, T.; Hara, T.
Capillary morphogenesis gene (CMG)-1 is among the genes differentially expressed in mouse male germ line stem cells and embryonic stem cells
Mol. Reprod. Dev.
73
955-966
2006
Mus musculus, Mus musculus DBA/2
Yao, T.; Song, L.; Xu, W.; DeMartino, G.N.; Florens, L.; Swanson, S.K.; Washburn, M.P.; Conaway, R.C.; Conaway, J.W.; Cohen, R.E.
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
Nat. Cell Biol.
8
994-1002
2006
Bos taurus (Q9XSJ0), Homo sapiens (Q9Y5K5)
Raichur, A.; Vali, S.; Gorin, F.
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinsons disease
Neuroscience
142
859-870
2006
Homo sapiens
Carmine Belin, A.; Westerlund, M.; Bergman, O.; Nissbrandt, H.; Lind, C.; Sydow, O.; Galter, D.
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinsons disease in Sweden
Parkinsonism Relat. Disord.
13
295-298
2007
Homo sapiens
Moon, W.J.; Hwang, D.K.; Park, E.J.; Kim, Y.M.; Chae, Y.K.
Recombinant expression, isotope labeling, refolding, and purification of an antimicrobial peptide, piscidin
Protein Expr. Purif.
51
141-146
2007
Saccharomyces cerevisiae (P35127), Saccharomyces cerevisiae
Yu, H.A.; Kim, S.G.; Kim, E.J.; Lee, W.J.; Kim, D.O.; Park, K.; Park, Y.C.; Seo, J.H.
Characterization of ubiquitin C-terminal hydrolase 1 (YUH1) from Saccharomyces cerevisiae expressed in recombinant Escherichia coli
Protein Expr. Purif.
56
20-26
2007
Saccharomyces cerevisiae
Ha, M.K.; Soo Cho, J.; Baik, O.R.; Lee, K.H.; Koo, H.S.; Chung, K.Y.
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis
Proteomics
6
3339-3351
2006
Caenorhabditis elegans, Homo sapiens (P09936), Caenorhabditis elegans N2
Susor, A.; Ellederova, Z.; Jelinkova, L.; Halada, P.; Kavan, D.; Kubelka, M.; Kovarova, H.
Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1
Reproduction
134
559-568
2007
Sus scrofa
Yamauchi, T.; Sakurai, M.; Abe, K.; Matsumiya, G.; Sawa, Y.
Ubiquitin-mediated stress response in the spinal cord after transient ischemia
Stroke
39
1883-1889
2008
Oryctolagus cuniculus
Nikko, E.; Andre, B.
Evidence for a direct role of the Doa4 deubiquitinating enzyme in protein sorting into the MVB pathway
Traffic
8
566-581
2007
Saccharomyces cerevisiae
Sun, J.; Ying, M.; Li, H.; Shang, X.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
Role of UCH-L1/ubiquitin in acute testicular ischemia-reperfusion injury
Biochem. Biophys. Res. Commun.
366
539-544
2008
Mus musculus (Q9R0P9), Mus musculus
Drag, M.; Mikolajczyk, J.; Bekes, M.; Reyes-Turcu, F.E.; Ellman, J.A.; Wilkinson, K.D.; Salvesen, G.S.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
Biochem. J.
415
367-375
2008
Severe acute respiratory syndrome-related coronavirus, Homo sapiens (P15374), Homo sapiens (P45974), Homo sapiens (Q5VVQ6), Homo sapiens
Tanaka, T.; Kuramitsu, Y.; Fujimoto, M.; Naito, S.; Oka, M.; Nakamura, K.
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones
Electrophoresis
29
2651-2659
2008
Homo sapiens (P09936), Homo sapiens
Sun, J.; Shang, X.; Tian, Y.; Zhao, W.; He, Y.; Chen, K.; Cheng, H.; Zhou, R.
Ubiquitin C-terminal hydrolase-L1 (Uch-L1) correlates with gonadal transformation in the rice field eel
FEBS J.
275
242-249
2008
Monopterus albus (B5KNK6)
Vasu, V.T.; Ott, S.; Hobson, B.; Rashidi, V.; Oommen, S.; Cross, C.E.; Gohil, K.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice
Free Radic. Res.
43
106-116
2009
Mus musculus (Q9R0P9)
Yu, J.; Tao, Q.; Cheung, K.F.; Jin, H.; Poon, F.F.; Wang, X.; Li, H.; Cheng, Y.Y.; Roecken, C.; Ebert, M.P.; Chan, A.T.; Sung, J.J.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
Hepatology
48
508-518
2008
Homo sapiens (P09936)
Wang, W.J.; Li, Q.Q.; Xu, J.D.; Cao, X.X.; Li, H.X.; Tang, F.; Chen, Q.; Yang, J.M.; Xu, Z.D.; Liu, X.P.
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells
Int. J. Oncol.
33
1037-1045
2008
Homo sapiens (P09936), Homo sapiens
Enesa, K.; Zakkar, M.; Chaudhury, H.; Luong, l.e..A.; Rawlinson, L.; Mason, J.C.; Haskard, D.O.; Dean, J.L.; Evans, P.C.
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
J. Biol. Chem.
283
7036-7045
2008
Homo sapiens
Rolen, U.; Freda, E.; Xie, J.; Pfirmann, T.; Frisan, T.; Masucci, M.G.
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation
J. Cell. Mol. Med.
13
1666-1678
2009
Homo sapiens, Homo sapiens (P09936)
Jin, W.; Chang, M.; Paul, E.M.; Babu, G.; Lee, A.J.; Reiley, W.; Wright, A.; Zhang, M.; You, J.; Sun, S.C.
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice
J. Clin. Invest.
118
1858-1866
2008
Mus musculus (Q80TQ2)
Meyer-Schwesinger, C.; Meyer, T.N.; Muenster, S.; Klug, P.; Saleem, M.; Helmchen, U.; Stahl, R.A.
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies
J. Pathol.
217
452-464
2009
Homo sapiens (P09936), Homo sapiens
Whitehurst, C.B.; Ning, S.; Bentz, G.L.; Dufour, F.; Gershburg, E.; Shackelford, J.; Langelier, Y.; Pagano, J.S.
The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity
J. Virol.
83
4345-4353
2009
Human gammaherpesvirus 4 (P03186), Human gammaherpesvirus 4
Misaghi, S.; Ottosen, S.; Izrael-Tomasevic, A.; Arnott, D.; Lamkanfi, M.; Lee, J.; Liu, J.; ORourke, K.; Dixit, V.M.; Wilson, A.C.
Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1
Mol. Cell. Biol.
29
2181-2192
2009
Homo sapiens (Q92560)
Lu, Y.; Adegoke, O.A.; Nepveu, A.; Nakayama, K.I.; Bedard, N.; Cheng, D.; Peng, J.; Wing, S.S.
USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1
Mol. Cell. Biol.
29
547-558
2009
Mus musculus (Q3UJD6), Rattus norvegicus (Q6J1Y9)
Yao, T.; Song, L.; Jin, J.; Cai, Y.; Takahashi, H.; Swanson, S.K.; Washburn, M.P.; Florens, L.; Conaway, R.C.; Cohen, R.E.; Conaway, J.W.
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
Mol. Cell
31
909-917
2008
Homo sapiens (Q9Y5K5), Homo sapiens
Setsuie, R.; Sakurai, M.; Sakaguchi, Y.; Wada, K.
Ubiquitin dimers control the hydrolase activity of UCH-L3
Neurochem. Int.
54
314-321
2009
Homo sapiens (P09936), Homo sapiens (P15374), Mus musculus (Q9JKB1), Mus musculus (Q9R0P9)
Kim, H.J.; Kim, Y.M.; Lim, S.; Nam, Y.K.; Jeong, J.; Kim, H.J.; Lee, K.J.
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis
Oncogene
28
117-127
2009
Homo sapiens (P09936)
Jin, F.L.; Xu, X.X.; Yu, X.Q.; Ren, S.X.
High-level expression of active recombinant ubiquitin carboxyl-terminal hydrolase of Drosophila melanogaster in Pichia pastoris
Protein Expr. Purif.
65
115-121
2009
Drosophila melanogaster
Nishio, K.; Kim, S.W.; Kawai, K.; Mizushima, T.; Yamane, T.; Hamazaki, J.; Murata, S.; Tanaka, K.; Morimoto, Y.
Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain
Biochem. Biophys. Res. Commun.
390
855-860
2009
Homo sapiens (Q9Y5K5)
Ichikawa, T.; Li, J.; Dong, X.; Potts, J.D.; Tang, D.Q.; Li, D.S.; Cui, T.
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation
Biochem. Biophys. Res. Commun.
391
852-856
2010
Rattus norvegicus (Q00981)
Fang, Y.; Fu, D.; Shen, X.Z.
The potential role of ubiquitin C-terminal hydrolases in oncogenesis
Biochim. Biophys. Acta
1806
1-6
2010
Homo sapiens, Mus musculus
Susor, A.; Liskova, L.; Toralova, T.; Pavlok, A.; Pivonkova, K.; Karabinova, P.; Lopatarova, M.; Sutovsky, P.; Kubelka, M.
Role of ubiquitin C-terminal hydrolase-L1 in antipolyspermy defense of mammalian oocytes
Biol. Reprod.
82
1151-1161
2010
Bos taurus
Andersson, F.I.; Jackson, S.E.; Hsu, S.T.
Backbone assignments of the 26 kDa neuron-specific ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1)
Biomol. NMR Assign.
4
41-43
2009
Homo sapiens (P09936), Homo sapiens
Weber, B.; Schaper, C.; Wang, Y.; Scholz, J.; Bein, B.
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation
Cell. Signal.
21
1513-1521
2009
Homo sapiens (P09936)
Li, L.; Tao, Q.; Jin, H.; van Hasselt, A.; Poon, F.F.; Wang, X.; Zeng, M.S.; Jia, W.H.; Zeng, Y.X.; Chan, A.T.; Cao, Y.
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma
Clin. Cancer Res.
16
2949-2958
2010
Homo sapiens
Wu, Y.R.; Chen, C.M.; Chen, Y.C.; Chao, C.Y.; Ro, L.S.; Fung, H.C.; Hsiao, Y.C.; Hu, F.J.; Lee-Chen, G.J.
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinsons disease among Taiwanese
Clin. Chim. Acta
411
955-958
2010
Homo sapiens
Papa, L.; Akinyi, L.; Liu, M.C.; Pineda, J.A.; Tepas, J.J.; Oli, M.W.; Zheng, W.; Robinson, G.; Robicsek, S.A.; Gabrielli, A.; Heaton, S.C.; Hannay, H.J.; Demery, J.A.; Brophy, G.M.; Layon, J.; Robertson, C.S.; Hayes, R.L.; Wang, K.K.
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury
Crit. Care Med.
38
138-144
2010
Homo sapiens
Suzuki, M.; Setsuie, R.; Wada, K.
Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis
Endocrinology
150
5230-5239
2009
Mus musculus
Liu, M.C.; Akinyi, L.; Scharf, D.; Mo, J.; Larner, S.F.; Muller, U.; Oli, M.W.; Zheng, W.; Kobeissy, F.; Papa, L.; Lu, X.C.; Dave, J.R.; Tortella, F.C.; Hayes, R.L.; Wang, K.K.
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats
Eur. J. Neurosci.
31
722-732
2010
Rattus norvegicus
Henderson, M.J.; Vij, N.; Zeitlin, P.L.
Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation
J. Biol. Chem.
285
11314-11325
2010
Homo sapiens
Kang, X.; Sun, L.; Guo, K.; Shu, H.; Yao, J.; Qin, X.; Liu, Y.
Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS
J. Cancer Res. Clin. Oncol.
136
1151-1159
2010
Homo sapiens
Ma, Y.; Zhao, M.; Zhong, J.; Shi, L.; Luo, Q.; Liu, J.; Wang, J.; Yuan, X.; Huang, C.
Proteomic profiling of proteins associated with lymph node metastasis in colorectal cancer
J. Cell. Biochem.
110
1512-1519
2010
Homo sapiens
Luo, J.; Megee, S.; Dobrinski, I.
Asymmetric distribution of UCH-L1 in spermatogonia is associated with maintenance and differentiation of spermatogonial stem cells
J. Cell. Physiol.
220
460-468
2009
Sus scrofa
Lewis, S.B.; Wolper, R.; Chi, Y.Y.; Miralia, L.; Wang, Y.; Yang, C.; Shaw, G.
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage
J. Neurosci. Res.
88
1475-1484
2010
Homo sapiens
Cartier, A.E.; Djakovic, S.N.; Salehi, A.; Wilson, S.M.; Masliah, E.; Patrick, G.N.
Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1
J. Neurosci.
29
7857-7868
2009
Rattus norvegicus
Liu, Y.; Wu, J.; Wu, H.; Wang, T.; Gan, H.; Zhang, X.; Liu, Y.; Li, R.; Zhao, Z.; Chen, Q.; Guo, M.; Zhang, Z.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro
J. Pathol.
217
642-653
2009
Rattus norvegicus
Seliger, B.; Handke, D.; Schabel, E.; Bukur, J.; Lichtenfels, R.; Dammann, R.
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma
J. Transl. Med.
7
90
2009
Homo sapiens
Koh, P.O.
Proteomic analysis of focal cerebral ischemic injury in male rats
J. Vet. Med. Sci.
72
181-185
2010
Rattus norvegicus
Iizuka, N.; Okamoto, K.; Matsushita, R.; Kimura, M.; Nagai, K.; Arito, M.; Kurokawa, M.S.; Masuko, K.; Suematsu, N.; Hirohata, S.; Kato, T.
Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement
Lupus
19
717-726
2010
Homo sapiens
Yeh, H.Y.; Klesius, P.H.
Characterization and tissue expression of channel catfish (Ictalurus punctatus Rafinesque, 1818) ubiquitin carboxyl-terminal hydrolase L5 (UCHL5) cDNA
Mol. Biol. Rep.
37
1229-1234
2010
Ictalurus punctatus (B6E460), Ictalurus punctatus, Ictalurus punctatus NWAC103 (B6E460)
Zetterberg, M.; Sjoelander, A.; von Otter, M.; Palmer, M.S.; Landgren, S.; Minthon, L.; Wallin, A.; Andreasen, N.; Blennow, K.; Zetterberg, H.
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimers disease
Mol. Neurodegener.
5
11
2010
Homo sapiens (P09936), Homo sapiens
Pfeffer, M.; Plenzig, S.; Gispert, S.; Wada, K.; Korf, H.W.; Von Gall, C.
Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene
Neurobiol. Aging
33
393-403
2012
Mus musculus
Goto, A.; Wang, Y.L.; Kabuta, T.; Setsuie, R.; Osaka, H.; Sawa, A.; Ishiura, S.; Wada, K.
Proteomic and histochemical analysis of proteins involved in the dying-back-type of axonal degeneration in the gracile axonal dystrophy (gad) mouse
Neurochem. Int.
54
330-338
2009
Mus musculus
Mitsui, T.; Hirayama, K.; Aoki, S.; Nishikawa, K.; Uchida, K.; Matsumoto, T.; Kabuta, T.; Wada, K.
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening
Neurochem. Int.
56
679-686
2010
Homo sapiens (P09936), Homo sapiens
Setsuie, R.; Suzuki, M.; Tsuchiya, Y.; Wada, K.
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses
Neurochem. Int.
56
911-918
2010
Mus musculus
Nagamine, S.; Kabuta, T.; Furuta, A.; Yamamoto, K.; Takahashi, A.; Wada, K.
Deficiency of ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) leads to vulnerability to lipid peroxidation
Neurochem. Int.
57
102-110
2010
Mus musculus, Mus musculus C57/BL6J
Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
PLoS ONE
4
e5955
2009
Homo sapiens, Mus musculus
Bheda, A.; Shackelford, J.; Pagano, J.S.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes
PLoS ONE
4
e6764
2009
Mus musculus
Liu, Z.; Meray, R.K.; Grammatopoulos, T.N.; Fredenburg, R.A.; Cookson, M.R.; Liu, Y.; Logan, T.; Lansbury, P.T.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease
Proc. Natl. Acad. Sci. USA
106
4635-4640
2009
Homo sapiens, Mus musculus
Chen, F.; Sugiura, Y.; Myers, K.G.; Liu, Y.; Lin, W.
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction
Proc. Natl. Acad. Sci. USA
107
1636-1641
2010
Mus musculus
Koharudin, L.M.; Liu, H.; Di Maio, R.; Kodali, R.B.; Graham, S.H.; Gronenborn, A.M.
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1
Proc. Natl. Acad. Sci. USA
107
6835-6840
2010
Homo sapiens
Boudreaux, D.A.; Maiti, T.K.; Davies, C.W.; Das, C.
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation
Proc. Natl. Acad. Sci. USA
107
9117-9122
2010
Homo sapiens (P09936)
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
Seliger, B.; Dressler, S.P.; Wang, E.; Kellner, R.; Recktenwald, C.V.; Lottspeich, F.; Marincola, F.M.; Baumgaertner, M.; Atkins, D.; Lichtenfels, R.
Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma
Proteomics
9
1567-1581
2009
Homo sapiens (P09936)
Gu, Y.Q.; Chen, Q.J.; Gu, Z.; Shi, Y.; Yao, Y.W.; Wang, J.; Sun, Z.G.; Tso, J.K.
Ubiquitin carboxyl-terminal hydrolase L1 contributes to the oocyte selective elimination in prepubertal mouse ovaries
Sheng Li Xue Bao
61
175-184
2009
Mus musculus, Mus musculus ICR
Ko, Y.M.; Chang, C.Y.; Chiou, S.J.; Hsu, F.J.; Huang, J.S.; Yang, Y.L.; Guh, J.Y.; Chuang, L.Y.
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-beta receptor I expression and hypertrophy in mesangial cells
Arch. Biochem. Biophys.
535
177-186
2013
Mus musculus
Song, H.M.; Lee, J.E.; Kim, J.H.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines
Biochem. Biophys. Res. Commun.
452
722-727
2014
Homo sapiens (P15374)
Navarro, M.F.; Carmody, L.; Romo-Fewell, O.; Lokensgard, M.E.; Love, J.J.
Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered alpha-linked ubiquitin substrates
Biochemistry
53
8031-8042
2014
Homo sapiens (P15374), Homo sapiens
Read, N.C.; Gutsol, A.; Holterman, C.E.; Carter, A.; Coulombe, J.; Gray, D.A.; Kennedy, C.R.
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis
Biochim. Biophys. Acta
1842
1028-1040
2014
Mus musculus
Davies, C.W.; Chaney, J.; Korbel, G.; Ringe, D.; Petsko, G.A.; Ploegh, H.; Das, C.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
Bioorg. Med. Chem. Lett.
22
3900-3904
2012
Homo sapiens (P09936)
Zheng, S.; Qiao, G.; Min, D.; Zhang, Z.; Lin, F.; Yang, Q.; Feng, T.; Tang, L.; Sun, Y.; Zhao, H.; Li, H.; Yu, W.; Yang, Y.; Shen, Z.; Yao, Y.
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma
Cancer Lett.
359
36-46
2015
Homo sapiens (P09936)
Thao, D.T.; An, P.N.; Yamaguchi, M.; LinhThuoc, T.
Overexpression of ubiquitin carboxyl terminal hydrolase impairs multiple pathways during eye development in Drosophila melanogaster
Cell Tissue Res.
348
453-463
2012
Drosophila melanogaster
Pang, L.; Wu, Y.; Dong, N.; Xu, D.H.; Wang, D.W.; Wang, Z.H.; Li, X.L.; Bian, M.; Zhao, H.J.; Liu, X.L.; Zhang, N.
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning
Clin. Biochem.
47
72-76
2014
Homo sapiens
Chipumuro, E.; Henriksen, M.
The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes
FASEB J.
26
842-854
2012
Homo sapiens
Boudreaux, D.A.; Chaney, J.; Maiti, T.K.; Das, C.
Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases
FEBS J.
279
1106-1118
2012
Homo sapiens (P09936), Homo sapiens (P15374), Homo sapiens (Q9Y5K5)
Wulfaenger, J.; Biehl, K.; Tetzner, A.; Wild, P.; Ikenberg, K.; Meyer, S.; Seliger, B.
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma
Int. J. Cancer
133
2522-2532
2013
Homo sapiens (P09936), Homo sapiens
Kabuta, T.; Mitsui, T.; Takahashi, M.; Fujiwara, Y.; Kabuta, C.; Konya, C.; Tsuchiya, Y.; Hatanaka, Y.; Uchida, K.; Hohjoh, H.; Wada, K.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity
J. Biol. Chem.
288
12615-12626
2013
Homo sapiens (P09936), Homo sapiens
Bishop, P.; Rubin, P.; Thomson, A.R.; Rocca, D.; Henley, J.M.
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons
J. Biol. Chem.
289
36140-36149
2014
Homo sapiens (P09936)
Diaz-Arrastia, R.; Wang, K.K.; Papa, L.; Sorani, M.D.; Yue, J.K.; Puccio, A.M.; McMahon, P.J.; Inoue, T.; Yuh, E.L.; Lingsma, H.F.; Maas, A.I.; Valadka, A.B.; Okonkwo, D.O.; Manley, G.T.; Manley, G.T.
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein
J. Neurotrauma
31
19-25
2014
Homo sapiens
Hartnett, S.; Zhang, F.; Abitz, A.; Li, Y.
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells
Neurosci. Lett.
564
115-119
2014
Mus musculus (Q9R0P9)
Lee, S.P.; Park, C.M.; Kim, K.S.; Kim, E.; Jeong, M.; Shin, J.Y.; Yun, C.H.; Kim, K.; Chock, P.B.; Chae, H.Z.
Structural and biochemical analyses reveal ubiquitin C-terminal hydrolase-L1 as a specific client of the peroxiredoxin II chaperone
Arch. Biochem. Biophys.
640
61-74
2018
Rattus norvegicus (Q00981)
Gao, H.; Hartnett, S.; Li, Y.
Ubiquitin C-terminal hydrolase L1 regulates myoblast proliferation and differentiation
Biochem. Biophys. Res. Commun.
492
96-102
2017
Mus musculus (Q9R0P9), Mus musculus
Song, I.K.; Kim, H.J.; Magesh, V.; Lee, K.J.
Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4
Biochem. Biophys. Res. Commun.
495
1567-1572
2018
Homo sapiens (P09936), Homo sapiens
Bishop, P.; Rocca, D.; Henley, J.M.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) structure, distribution and roles in brain function and dysfunction
Biochem. J.
473
2453-2462
2016
Homo sapiens (P09936), Mus musculus (Q9R0P9)
Kang, S.J.; Kim, J.S.; Park, S.M.
Ubiquitin C-terminal hydrolase L1 regulates lipid raft-dependent endocytosis
Exp. Neurobiol.
27
377-386
2018
Homo sapiens (P09936)
Wang, D.H.; Song, W.; Wei, S.W.; Zheng, Y.F.; Chen, Z.S.; Han, J.D.; Zhang, H.T.; Luo, J.C.; Qin, Y.M.; Xu, Z.H.; Bai, S.N.
Characterization of the ubiquitin C-terminal hydrolase and ubiquitin-specific protease families in rice (Oryza sativa)
Front. Plant Sci.
9
1636
2018
Oryza sativa, Oryza sativa (Q6ETK2), Oryza sativa (Q6K6Z5)
Radon, V.; Czesla, M.; Reichelt, J.; Fehlert, J.; Hammel, A.; Rosendahl, A.; Knop, J.H.; Wiech, T.; Wenzel, U.O.; Sachs, M.; Reinicke, A.T.; Stahl, R.A.K.; Meyer-Schwesinger, C.
Ubiquitin C-terminal hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney
Kidney Int.
93
110-127
2018
Mus musculus (Q9R0P9)
Wang, W.; Zou, L.; Zhou, D.; Zhou, Z.; Tang, F.; Xu, Z.; Liu, X.
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway
Mol. Carcinog.
55
1329-1342
2016
Homo sapiens (P09936)
Toliczenko-Bernatowicz, D.; Matuszczak, E.; Tylicka, M.; Szymanska, B.; Komarowska, M.; Gorodkiewicz, E.; Debek, W.; Hermanowicz, A.
Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism
PLoS ONE
13
e0191806
2018
Homo sapiens (P09936), Homo sapiens
Nan, L.; Jacko, A.M.; Tan, J.; Wang, D.; Zhao, J.; Kass, D.J.; Ma, H.; Zhao, Y.
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
Sci. Rep.
6
33116
2016
Homo sapiens (Q9Y5K5), Homo sapiens
Sivakumar, D.; Stein, M.
Binding of SARS-CoV covalent non-covalent inhibitors to the SARS-CoV-2 papain-like protease and ovarian tumor domain deubiquitinases
Biomolecules
11
802
2021
Homo sapiens (Q96DC9), Homo sapiens (Q96FW1)
Durie, I.A.; Dzimianski, J.V.; Daczkowski, C.M.; McGuire, J.; Faaberg, K.; Pegan, S.D.
Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin
Acta Crystallogr. D Struct. Biol.
77
943-953
2021
porcine epidemic diarrhea virus (A0A059VJE6), porcine epidemic diarrhea virus
html completed
