Application | Comment | Organism |
---|---|---|
additional information | dynamic regulation of apically located epithelial sodium channel by recycling, which is facilitated by UCH-L3 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,5,6,7-tetrachloroindan-1,3-dione | UCH-L3 inhibition reduces epithelial sodium channel currents, decreases apical membrane epithelial sodium channel expression and increases epithelial sodium channel ubiquitination at the apical surface | Mus musculus | |
siRNA | knockdown of UCH-L3 leads to a decrease of epithelial sodium channel currents | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Mus musculus | 5768 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
collecting duct | - |
Mus musculus | - |
epithelial cell | UCH-L3 is the predominant deubiquitinating enzyme in endosomal compartments of collecting duct epithelial cells | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin C-terminal hydrolase isoform L3 | - |
Mus musculus |
UCH-L3 | - |
Mus musculus |