Application | Comment | Organism |
---|---|---|
additional information | UCH-L1 and UCH-L3 may have a role in growth transformation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | UCHL3 and UCH37 are upregulated in the majority of tumor tissues compared to the adjacent normal tissues. UCH-L1 activity is lower in a significant proportion of the tumors but to a less extent in advanced tumors | Homo sapiens | - |
cervical cancer cell line | in accordance with the relatively low UCH-L1 activity in tumor biopsies, UCH-L1 is detected only in one out of eight cervical carcinoma lines | Homo sapiens | - |
keratinocyte | only UCH-L3 is clearly identified in primary keratinocytes. UCH-L1 and UCH-L3 activity is upregulated following HPV E6/E7 immortalization of keratinocytes | Homo sapiens | - |
additional information | the human papilloma virus-negative C33A cell line is the only cell line lacking detectable UCH-L3 activity | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hemagglutinin-tagged ubiquitin-vinyl methyl ester + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C-terminal hydrolases UCHL3 | - |
Homo sapiens |
PGP 9.5 | - |
Homo sapiens |
UCH-L1 | - |
Homo sapiens |
UCH37 | - |
Homo sapiens |
Uchl3 | - |
Homo sapiens |