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Literature summary for 3.4.19.12 extracted from

  • Rolen, U.; Kobzeva, V.; Gasparjan, N.; Ovaa, H.; Winberg, G.; Kisseljov, F.; Masucci, M.G.
    Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines (2006), Mol. Carcinog., 45, 260-269.
    View publication on PubMed

Application

Application Comment Organism
additional information UCH-L1 and UCH-L3 may have a role in growth transformation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell UCHL3 and UCH37 are upregulated in the majority of tumor tissues compared to the adjacent normal tissues. UCH-L1 activity is lower in a significant proportion of the tumors but to a less extent in advanced tumors Homo sapiens
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cervical cancer cell line in accordance with the relatively low UCH-L1 activity in tumor biopsies, UCH-L1 is detected only in one out of eight cervical carcinoma lines Homo sapiens
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keratinocyte only UCH-L3 is clearly identified in primary keratinocytes. UCH-L1 and UCH-L3 activity is upregulated following HPV E6/E7 immortalization of keratinocytes Homo sapiens
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additional information the human papilloma virus-negative C33A cell line is the only cell line lacking detectable UCH-L3 activity Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemagglutinin-tagged ubiquitin-vinyl methyl ester + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
C-terminal hydrolases UCHL3
-
Homo sapiens
PGP 9.5
-
Homo sapiens
UCH-L1
-
Homo sapiens
UCH37
-
Homo sapiens
Uchl3
-
Homo sapiens