Application | Comment | Organism |
---|---|---|
drug development | the enzyme may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one | i.e. b-AP15, administration of the UCHL5 inhibitor reduces the expression of FN, type I collagen, Smad2/Smad3, and the deposition of collagen in lung tissues in a bleomycin-induced model of pulmonary fibrosis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitinyl-Smad2 + H2O | Homo sapiens | the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability | ubiquitin + Smad2 | - |
? | |
ubiquitinyl-Smad3 + H2O | Homo sapiens | the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability | ubiquitin + Smad3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y5K5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | the enzyme is highly expressed in idiopathic pulmonary fibrosis lungs | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquitinyl-Smad2 + H2O | the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability | Homo sapiens | ubiquitin + Smad2 | - |
? | |
ubiquitinyl-Smad3 + H2O | the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability | Homo sapiens | ubiquitin + Smad3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase-L5 | - |
Homo sapiens |
UCHL5 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme de-ubiquitinates both ubiquitinyl-Smad2 and ubiquitinyl-Smad3 and up-regulates their stability. It mitigates TGFbeta-1 signaling by stabilizing Smad2/Smad3. Inhibition or down-regulation of ubiquitin carboxyl-terminal hydrolase-L5 reduces Smad2/Smad3 levels and TGFbeta-1-induces the expression of fibronectin and alpha-SMA in human lung fibroblast | Homo sapiens |