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Literature summary for 3.4.19.12 extracted from

  • Nan, L.; Jacko, A.M.; Tan, J.; Wang, D.; Zhao, J.; Kass, D.J.; Ma, H.; Zhao, Y.
    Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis (2016), Sci. Rep., 6, 33116 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development the enzyme may contribute to the pathogenesis of idiopathic pulmonary fibrosis and may be a potential therapeutic target Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one i.e. b-AP15, administration of the UCHL5 inhibitor reduces the expression of FN, type I collagen, Smad2/Smad3, and the deposition of collagen in lung tissues in a bleomycin-induced model of pulmonary fibrosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquitinyl-Smad2 + H2O Homo sapiens the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability ubiquitin + Smad2
-
?
ubiquitinyl-Smad3 + H2O Homo sapiens the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability ubiquitin + Smad3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5K5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung the enzyme is highly expressed in idiopathic pulmonary fibrosis lungs Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquitinyl-Smad2 + H2O the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability Homo sapiens ubiquitin + Smad2
-
?
ubiquitinyl-Smad3 + H2O the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability Homo sapiens ubiquitin + Smad3
-
?

Synonyms

Synonyms Comment Organism
ubiquitin carboxyl-terminal hydrolase-L5
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Homo sapiens
UCHL5
-
Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme de-ubiquitinates both ubiquitinyl-Smad2 and ubiquitinyl-Smad3 and up-regulates their stability. It mitigates TGFbeta-1 signaling by stabilizing Smad2/Smad3. Inhibition or down-regulation of ubiquitin carboxyl-terminal hydrolase-L5 reduces Smad2/Smad3 levels and TGFbeta-1-induces the expression of fibronectin and alpha-SMA in human lung fibroblast Homo sapiens