Application | Comment | Organism |
---|---|---|
medicine | activation of UCH-L1 may be a useful therapeutic approach for treating Alzheimers disease. Administration of a UCH-L1 fused to the transduction domain of the HIV-transactivator protein to supplement endogenous UCH-L1 has a protective effect on memory loss in a mouse model of Alzheimers disease. It restores long term potentiation and contextual memory to normal levels, whereas levels of the regulatory subunit of protein kinase A decrease, which, in turn, leads to increased levels of phosopho-cAMP response element binding protein | Mus musculus |
medicine | expression of UCH-L1 is increased during long-term facilitation, which is related to synaptic plasticity and learning | Aplysia sp. |
medicine | UCH-L1 has a putative but still undefined role in the ubiquitin-dependent protein degradation pathway. Postmortem analysis of human brains shows this pathway to be compromised in Alzheimers disease. A polymorphism in the UCH-L1 gene increases the risk of Alzheimers disease in females and also effects the risk of Parkinsons disease in Asian populations | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C90S | inhibits the protective action of endogenous UCH-L1. C90S-fusion protein does not rescue the deficit in long term potentiation induced by Abeta, acts as a dominant negative mutant, causes a deficit in long term potentiation in the absence of oligomeric Abeta | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment of hippocampal slices with a small-molecule inhibitor of UCH-L1 enzymatic activity produces a deficit in long term potentiation | Mus musculus | |
oligomeric Abeta | treatment of hippocampal slices produces a deficit in long term potentiation. Effect can be reversed by coadministering a recombinant UCH-L1 protein | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aplysia sp. | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
hippocampus | - |
Mus musculus | - |
additional information | absence of UCHL1 in the gracile axonal dystrophy mouse, which results in neurodegeneration | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
UCH-L1 | - |
Mus musculus |
UCH-L1 | - |
Homo sapiens |
UCH-L1 | - |
Aplysia sp. |