Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | healthy persons, and liver cirrhosis and HCC patients, quantitative USP44 determination, overview | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
ubiquitin carboxyl-terminal hydrolase 44 | - |
Homo sapiens |
ubiquitin-specific protease 44 | - |
Homo sapiens |
USP44 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | the deubiquitinating enzyme USP44 is a critical regulator of the spindle checkpoint, dysregulation of the spindle checkpoint can contribute to birth defects and tumorigenesis | Homo sapiens |
metabolism | USP44 is a member of the ubiquitin proteasome pathway controlling intracellular protein degradation, functioning to maintain ubiquitin balance by associating with ubiquitin and by releasing ubiquitin from tandemly conjugated ubiquitin monomers and small adducts or unfolded proteins | Homo sapiens |
physiological function | USP44 is a member of the ubiquitin proteasome pathway controlling intracellular protein degradation, functioning to maintain ubiquitin balance by associating with ubiquitin and by releasing ubiquitin from tandemly conjugated ubiquitin monomers and small adducts or unfolded proteins. Deubiquitinating enzyme USP44 is a critical regulator of the spindle checkpoint | Homo sapiens |