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Literature summary for 3.4.19.12 extracted from

  • Yamauchi, T.; Sakurai, M.; Abe, K.; Matsumiya, G.; Sawa, Y.
    Ubiquitin-mediated stress response in the spinal cord after transient ischemia (2008), Stroke, 39, 1883-1889.
    View publication on PubMed
Search for more literature for 3.4.19.12

Application

Application Comment Organism
medicine transient ischemia induces selective delayed motor neuronal death and affects the profile of expression of ubiquitin, parkin, and UCH-L1. Vulnerability of motor neuron of the spinal cord may be partially attributed to the different response in ubiquitin-mediated stress response after transient ischemia Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm UCH-L1 is slightly expressed both in interneuron and motor neuron. After 3 hours ischemia, UCH-L1 is upregulated in cytoplasm of both neurons. After 6 hours, UCH-L1 in cytoplasm is preserved in motor neuron, whereas it returns to almost the same level as the sham group in interneuron Oryctolagus cuniculus 5737
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additional information UCH-L1 is not detectable in nuclei of interneuron and motor neuron. UCH-L1 is upregulated strongly at 3 hours and somewhat decreased at 6 hours of ischemia, is well preserved until 1 day, whereas it is not detectable in nuclei of motor neuron after ischemia Oryctolagus cuniculus
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
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 Western blot analysis Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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Source Tissue

Source Tissue Comment Organism Textmining
neuron interneuron and motor neuron Oryctolagus cuniculus
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spinal cord
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 Oryctolagus cuniculus
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Synonyms

Synonyms Comment Organism
ubiquitin carboxy-terminal hydrolase 1
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 Oryctolagus cuniculus
UCH-L1
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 Oryctolagus cuniculus