Literature summary for 3.4.19.12 extracted from

Zheng, S.; Qiao, G.; Min, D.; Zhang, Z.; Lin, F.; Yang, Q.; Feng, T.; Tang, L.; Sun, Y.; Zhao, H.; Li, H.; Yu, W.; Yang, Y.; Shen, Z.; Yao, Y.
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma (2015), Cancer Lett., 359, 36-46.

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Application

Application	Comment	Organism
medicine	expression of isoform UCHL1 is elevated in osteosarcoma compared with normal bone tissue. UCHL1 expression level is correlated with tumor maximum diameter, high rate of lung metastases and short survival time. Knockdown of UCHL1 in osteosarcoma cell MG-63 inhibits cell proliferation and significantly increases cell population in the G1 phase. Cyclins promoting G1/S phase transition are reduced after UCHL1 knockdown, including cell cycle regulator cyclin D1, cyclin E1 and CDK6. Inhibition of UCHL1 in MG-63 cells dramatically induces cell apoptosis. Downregulation of UCHL1 in MG-63 significantly inhibits cell invasion. There is a positive correlation between UCHL1 expression level and the Akt and ERK phosphorylation status	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P09936	isoform UCHL1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MG-63 cell	-	Homo sapiens	-
SAOS-2 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
UCHL1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression of isoform UCHL1 is elevated in osteosarcoma	up

General Information

General Information	Comment	Organism
physiological function	expression of isoform UCHL1 is elevated in osteosarcoma compared with normal bone tissue. UCHL1 expression level is correlated with tumor maximum diameter, high rate of lung metastases and short survival time. Knockdown of UCHL1 in osteosarcoma cell MG-63 inhibits cell proliferation and significantly increases cell population in the G1 phase. Cyclins promoting G1/S phase transition are reduced after UCHL1 knockdown, including cell cycle regulator cyclin D1, cyclin E1 and CDK6. Inhibition of UCHL1 in MG-63 cells dramatically induces cell apoptosis. Downregulation of UCHL1 in MG-63 significantly inhibits cell invasion. There is a positive correlation between UCHL1 expression level and the Akt and ERK phosphorylation status	Homo sapiens

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Release 2023.1 (January 2023)