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alpha-L-Asp1-Val5-angiotensin II + H2O
beta-Asp1-Val5-angiotensin II
-
transformation to beta form
-
ir
Arg-4-methylcoumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
?
Arg-4-nitroanilide + H2O
Arg + 4-nitroaniline
-
-
-
?
arginine vasopressin + H2O
?
-
-
-
-
?
Cys-4-nitroanilide + H2O
Cys + 4-nitroaniline
L-Ala-2-naphthylamide + H2O
L-Ala + 2-naphthylamine
-
-
-
-
?
L-alanine-p-nitroanilide + H2O
L-alanine + p-nitroaniline
L-Arg-2-naphthylamide + H2O
L-Arg + 2-naphthylamine
-
-
-
-
?
L-Arg-vasopressin + H2O
L-Arg + vasopressin
-
-
-
-
?
L-arginine-7-amido-4-methylcoumarin + H2O
L-arginine + 7-amino-4-methylcoumarin
-
-
-
?
L-benzyl-L-Cys-2-naphthylamide + H2O
L-benzyl-L-Cys + 2-naphthylamine
-
-
-
-
?
L-benzyl-L-cysteine-p-nitroanilide + H2O
L-benzyl-L-cysteine + p-nitroaniline
-
-
-
-
?
L-Cys-beta-naphthylamide + H2O
L-Cys + beta-naphthylamine
L-cystine di-beta-naphthylamide + H2O
?
L-cystine-di-beta-naphthylamide + 2 H2O
L-cystine + 2 beta-naphthylamine
L-cystine-di-p-nitroanilide + H2O
L-cystine + p-nitroaniline
L-Leu-2-naphthylamide + H2O
2-naphthylamine + L-Leu
-
-
-
-
?
L-Leu-2-naphthylamide + H2O
L-Leu + 2-naphthylamine
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
L-Leu-enkephalin + H2O
L-Leu + enkephalin
-
-
-
-
?
L-Leu-p-nitroanilide + H2O
L-Leu + p-nitroaniline
-
-
-
-
?
L-leucine-7-amido-4-methylcoumarin + H2O
L-leucine + 7-amino-4-methylcoumarin
-
-
-
?
L-leucine-p-nitroanilide + H2O
L-leucine + p-nitroaniline
-
-
-
-
?
L-Lys-2-naphthylamide + H2O
L-Lys + 2-naphthylamine
-
-
-
-
?
L-lysine-p-nitroanilide + H2O
L-lysine + p-nitroaniline
L-methionine-p-nitroanilide + H2O
L-methionine + p-nitroaniline
-
-
-
-
?
L-Phe-7-amido-4-methylcoumarin + H2O
L-Phe + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Trp-2-naphthylamide + H2O
L-Trp + 2-naphthylamine
-
-
-
-
?
Leu-4-methylcoumaryl-7-amide + H2O
Leu + 7-amino-4-methylcoumarin
Leu-4-nitroanilide + H2O
Leu + 4-nitroaniline
-
-
-
?
leucyl-beta-naphthylamide + H2O
leucine + beta-naphthylamine
-
-
-
?
LGGGGGL + H2O
L-Leu + GGGGGL
hydrolysis of poly-glycine peptides, overview
-
-
?
Lys-4-methylcoumaryl-7-amide + H2O
Lys + 7-amino-4-methylcoumarin
-
-
-
?
lysine-vasopressin + H2O
?
-
-
-
-
?
Met-4-methylcoumaryl-7-amide + H2O
Met + 7-amino-4-methylcoumarin
-
-
-
?
oxytocin + H2O
acyclic peptide + H2O
Peptides + H2O
?
-
enzyme plays a role in general metabolism of peptides during pregnancy
-
-
?
S-benzyl-Cys-4-methylcoumaryl-7-amide + H2O
S-benzyl-Cys + 7-amino-4-methylcoumarin
-
-
-
?
S-benzyl-cysteine-4-methylcoumarin 7-amide + H2O
S-benzyl-cysteine + 7-amino-4-methylcoumarin
-
-
-
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O
S-benzyl-L-cysteine + p-nitroaniline
somatostatin + H2O
?
-
-
-
-
?
vasopressin + H2O
hydrolyzed vasopressin
additional information
?
-
angiotensin III + H2O

?
-
-
-
-
?
angiotensin III + H2O
?
-
P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin
-
-
?
angiotensin III + H2O
?
-
the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III
-
-
?
Cys-4-nitroanilide + H2O

Cys + 4-nitroaniline
-
-
-
?
Cys-4-nitroanilide + H2O
Cys + 4-nitroaniline
-
-
-
-
?
L-alanine-p-nitroanilide + H2O

L-alanine + p-nitroaniline
-
-
-
-
?
L-alanine-p-nitroanilide + H2O
L-alanine + p-nitroaniline
-
-
-
-
?
L-Cys-beta-naphthylamide + H2O

L-Cys + beta-naphthylamine
-
-
-
?
L-Cys-beta-naphthylamide + H2O
L-Cys + beta-naphthylamine
-
-
-
?
L-cystine di-beta-naphthylamide + H2O

?
-
-
-
-
?
L-cystine di-beta-naphthylamide + H2O
?
-
-
-
-
?
L-cystine-di-beta-naphthylamide + 2 H2O

L-cystine + 2 beta-naphthylamine
-
-
-
?
L-cystine-di-beta-naphthylamide + 2 H2O
L-cystine + 2 beta-naphthylamine
in the presence of thiol, the substrate is converted to L-cystine beta-naphthylamide
-
-
?
L-cystine-di-beta-naphthylamide + 2 H2O
L-cystine + 2 beta-naphthylamine
in the presence of thiol, the substrate is converted to L-cystine beta-naphthylamide
-
-
?
L-cystine-di-beta-naphthylamide + 2 H2O
L-cystine + 2 beta-naphthylamine
-
-
-
?
L-cystine-di-p-nitroanilide + H2O

L-cystine + p-nitroaniline
-
-
-
-
?
L-cystine-di-p-nitroanilide + H2O
L-cystine + p-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O

L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-Leu-4-nitroanilide + H2O
L-Leu + 4-nitroaniline
-
-
-
-
?
L-lysine-p-nitroanilide + H2O

L-lysine + p-nitroaniline
-
-
-
-
?
L-lysine-p-nitroanilide + H2O
L-lysine + p-nitroaniline
-
-
-
-
?
L-lysine-p-nitroanilide + H2O
L-lysine + p-nitroaniline
-
-
-
-
?
L-lysine-p-nitroanilide + H2O
L-lysine + p-nitroaniline
-
-
-
-
?
Leu-4-methylcoumaryl-7-amide + H2O

Leu + 7-amino-4-methylcoumarin
-
-
-
?
Leu-4-methylcoumaryl-7-amide + H2O
Leu + 7-amino-4-methylcoumarin
-
-
-
-
?
oxytocin + H2O

?
-
-
-
-
?
oxytocin + H2O
?
-
in the placenta the enzyme is thought to play a role in the prevention of premature labour and maintenance of an adequate blood flow to the uterus
-
-
?
oxytocin + H2O
?
-
P-LAP in HUVEC cells regulates effects of oxytocin with resolution
-
-
?
oxytocin + H2O
?
-
cleavage sites: Cys-/-Tyr-/-Ile-/-Gln-/-Asn-/-Cys-Pro-Leu-Gly-NH2
-
-
?
oxytocin + H2O
?
-
cleavage sites: Cys-/-Tyr-/-Phe-/-Gln-Asn-Cys-Pro-Arg-Gly-NH2
-
-
?
oxytocin + H2O
?
-
enzyme opens the N-terminal cystine loop of oxytocin
-
-
?
oxytocin + H2O
?
a macrocyclic IRAP substrate
-
-
?
oxytocin + H2O
?
-
-
N-terminal processing
-
?
oxytocin + H2O

acyclic peptide + H2O
-
-
-
-
?
oxytocin + H2O
acyclic peptide + H2O
-
-
tyrosyl-isoleucyl-glutaminyl-asparaginyl-S-(S-cysteine)cysteinyl-prolyl-leucyl-glycinamide, first product
?
oxytocin + H2O
acyclic peptide + H2O
-
cleavage of bond between N-terminal cysteine and adjacent tyrosine
-
-
?
oxytocin + H2O
acyclic peptide + H2O
-
-
-
-
?
oxytocin + H2O
acyclic peptide + H2O
-
-
-
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O

S-benzyl-L-cysteine + p-nitroaniline
-
-
-
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O
S-benzyl-L-cysteine + p-nitroaniline
-
-
-
-
?
S-benzyl-L-cysteine-p-nitroanilide + H2O
S-benzyl-L-cysteine + p-nitroaniline
-
-
-
-
?
Vasopressin + H2O

?
-
-
-
-
?
Vasopressin + H2O
?
-
-
-
?
Vasopressin + H2O
?
-
P-LAP/OTase may be involved in maintaining pregnancy homeostasis via metabolizing peptides such as oxytocin and vasopressin
-
-
?
Vasopressin + H2O
?
-
the enzyme plays a role in blood pressure regulation via hydrolyzing vasopressin and angiotensin III
-
-
?
Vasopressin + H2O
?
a macrocyclic IRAP substrate
-
-
?
Vasopressin + H2O
?
-
-
-
?
Vasopressin + H2O
?
inactivation of vasopressin
-
-
?
Vasopressin + H2O
?
-
-
-
?
Vasopressin + H2O
?
inactivation of vasopressin
-
-
?
Vasopressin + H2O
?
-
-
-
?
Vasopressin + H2O
?
-
-
-
?
vasopressin + H2O

hydrolyzed vasopressin
-
-
-
-
?
vasopressin + H2O
hydrolyzed vasopressin
-
vasopressin is a physiological substrate
N-terminal processing
-
?
vasopressin + H2O
hydrolyzed vasopressin
-
-
-
-
?
additional information

?
-
-
broad specificity
-
-
?
additional information
?
-
-
broad specificity
-
-
?
additional information
?
-
-
broad specificity
-
-
?
additional information
?
-
-
S-benzyl-Cys-Pro-Leu-Gly(NH2)
-
-
?
additional information
?
-
-
peptides having proline as the second amino acid residue
-
-
?
additional information
?
-
-
peptides having proline as the second amino acid residue
-
-
?
additional information
?
-
-
peptides having proline as the second amino acid residue
-
-
?
additional information
?
-
-
not: L-Asp-beta-naphthylamide, L-Glu-beta-naphthylamide
-
-
?
additional information
?
-
-
glycyl-p-nitroanilide
-
-
?
additional information
?
-
-
hydrolyses neutral, aromatic, basic and acidic N-terminal amino acids from peptides
-
-
?
additional information
?
-
-
N-terminal aspartic acid bound via its beta-carboxyl group in a peptide bond
-
-
?
additional information
?
-
-
N-terminal aspartic acid bound via its beta-carboxyl group in a peptide bond
-
-
?
additional information
?
-
-
in individuals with type 2 diabetes the insulin-stimulated translocation of IRAP to the cell-surface of muscle and fat cells is impaired. This defect may lead to decreased cleavage and consequently increased action of peptide hormones that are substrates for IRAP. Impaiered IRAP action may thus play a role in the development of complications in type 2 diabetes
-
-
?
additional information
?
-
-
involvement of the enzyme in memory processing. AT4 ligands, upon binding to the catalytic site of insulin-regulated aminopeptidase, enhance spatial learning, facilitate memory retention and retrieval and reverse amnesia
-
-
?
additional information
?
-
-
vasopressinase cannot degrade 1-deamino-8D-arginine vasopressin
-
-
?
additional information
?
-
no activity with 1-deamino-8-D-arginine vasopressin
-
-
?
additional information
?
-
-
no activity with 1-deamino-8-D-arginine vasopressin
-
-
?
additional information
?
-
-
IRAP is required for maintenance of key constituents of endosome-derived vesicles in cardiac muscle cells
-
-
?
additional information
?
-
-
IRAP is involved in glucose transporter GLUT4 storage vesicle trafficking
-
-
?
additional information
?
-
recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4
-
-
?
additional information
?
-
-
recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4
-
-
?
additional information
?
-
recombinant IRAP bound to TUG, and this interaction is mapped to a short peptide in IRAP which is critical for GLUT4 intracellular retention. TUG controls vesicle translocation by interacting with IRAP as well as GLUT4
-
-
?
additional information
?
-
-
the enzyme plays an imprtant role for IRAP in reproductive physiology in regulating the action of peptide hormones
-
-
?
additional information
?
-
-
activity is greatly increased in rats with mammary tumors. The activity may be involved in the promotion and progression of breast cancer through oxytocin, vasopressin and/or renin-angiotensin system misregulation
-
-
?
additional information
?
-
-
the enzyme is involved in the metabolism of angiotensin
-
-
?
additional information
?
-
-
the enzyme plays a role as a mediator for the effects of angiotensin IV and related peptides on extracellular dopamine levels in striatum
-
-
?
additional information
?
-
-
the enzyme plays diverse physiological roles in the rat central nervous system
-
-
?
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